Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sidath C Kumarapperuma"'
Autor:
Roslyn A Taylor, Sixia Xiao, Ann M Carias, Michael D McRaven, Divya N Thakkar, Mariluz Araínga, Edward J Allen, Kenneth A Rogers, Sidath C Kumarapperuma, Siqi Gong, Angela J Fought, Meegan R Anderson, Yanique Thomas, Jeffrey R Schneider, Beth Goins, Peter Fox, Francois J Villinger, Ruth M Ruprecht, Thomas J Hope
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009632 (2021)
Human immunodeficiency virus (HIV) vaccines have not been successful in clinical trials. Dimeric IgA (dIgA) in the form of secretory IgA is the most abundant antibody class in mucosal tissues, making dIgA a prime candidate for potential HIV vaccines.
Externí odkaz:
https://doaj.org/article/cc676bc5c0da4fd2ae31cd68f66412e3
Autor:
Sidath C. Kumarapperuma, Thomas J. Hope, Kenneth A. Rogers, Peter T. Fox, Edward J. Allen, Ruth M. Ruprecht, Mariluz Araínga, Francois Villinger, Yanique Thomas, Ann M. Carias, Meegan R. Anderson, Sixia Xiao, Jeffrey R. Schneider, Siqi Gong, Michael D. McRaven, Angela J. Fought, Roslyn A. Taylor, Beth Goins, Divya N. Thakkar
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009632 (2021)
PLoS Pathogens
PLoS Pathogens
Human immunodeficiency virus (HIV) vaccines have not been successful in clinical trials. Dimeric IgA (dIgA) in the form of secretory IgA is the most abundant antibody class in mucosal tissues, making dIgA a prime candidate for potential HIV vaccines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15cb5f5661d494210cc2e8472676fd8
https://doaj.org/article/cc676bc5c0da4fd2ae31cd68f66412e3
https://doaj.org/article/cc676bc5c0da4fd2ae31cd68f66412e3
Autor:
Darrell J. Irvine, Torben Schiffner, Josetta Adams, Talar Tokatlian, Wei Zhang, Mariane B. Melo, William R. Schief, Crystal G. Franklin, Siqi Gong, Brittany L. Hartwell, Diane G. Carnathan, Ruth M. Ruprecht, Benjamin J. Cossette, Sergey Menis, Sidath C. Kumarapperuma, Guido Silvestri, Jacob T. Martin, Peter T. Fox, Beth Goins
Publikováno v:
Biomaterials
Elsevier
Elsevier
Antigen accumulation in lymph nodes (LNs) is critical for vaccine efficacy, but understanding of vaccine biodistribution in humans or large animals remains limited. Using the rhesus macaque model, we employed a combination of positron emission tomogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c95baa91a5256fd8a0edfed9720ab
https://doi.org/10.1016/j.biomaterials.2021.120868
https://doi.org/10.1016/j.biomaterials.2021.120868
Autor:
Barry C. Finzel, Rachit Shah, Andrew L Zhou, Sidath C. Kumarapperuma, Carston R. Wagner, Alexander M. Strom, Kimberly M. Maize
Publikováno v:
Molecular Pharmaceutics. 14:3987-3997
Nucleotide analogues that incorporate a metabolically labile nucleoside phosphoramidate (a ProTide) have found utility as prodrugs. In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202cf8d9561b2b3b4a4368c8a2eefa0f
https://doi.org/10.1021/acs.molpharmaceut.7b00664
https://doi.org/10.1021/acs.molpharmaceut.7b00664
Autor:
Sidath C. Kumarapperuma, Carston R. Wagner, Rachit Shah, Amit Gangar, Adrian Fegan, Jacob R. Petersburg
Chemically self-assembled nanorings (CSANs) are made of dihydrofolate reductase (DHFR) fusion proteins and have been successfully used in vitro for cellular cargo delivery and cell surface engineering applications. However, CSANs have yet to be evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72b5bd01cdb3149f88cbd9b315eec77
https://europepmc.org/articles/PMC5568902/
https://europepmc.org/articles/PMC5568902/
Publikováno v:
Molecular Pharmaceutics. 9:3218-3227
Chemically self-assembled antibody nanorings (CSANs) displaying multiple copies of single-chain variable fragments can be prepared from dihydrofolate reductase (DHFR) fusion proteins and bis-methotrexate (bisMTX). We have designed and synthesized a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb7c52c4b0373007e49171f897adf90
https://doi.org/10.1021/mp300303k
https://doi.org/10.1021/mp300303k
Autor:
Sidath C. Kumarapperuma, Colleen B. Jonsson, Jeffrey B. Arterburn, Marjan Jeselnik, William B. Parker, Yanjie Sun, Kiwon Chung
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract Variation of the 3-substituents in a series of bioisosteric and homologated 1-β-d-ribofuranosyl-1,2,4-triazoles has marked effects on activity with the human adenosine kinase, and analysis of computational descriptors and binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5819fe87041453d45f8474a870541fa
http://europepmc.org/articles/PMC7127453
http://europepmc.org/articles/PMC7127453
Autor:
Kimberly M. Maize, Barry C. Finzel, Alexander M. Strom, Rachit Shah, Sidath C. Kumarapperuma, Carston R. Wagner
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a300-a300
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25c2b689a2b95fefc394572a6175d72
https://doi.org/10.1107/s0108767317097069
https://doi.org/10.1107/s0108767317097069
Autor:
Kathryn A. Hanley, Jeffrey B. Arterburn, Sarah R. Gonzales, Michael McDowell, Marjan Jeselnik, Sidath C. Kumarapperuma
Publikováno v:
Antiviral Research. 87:78-80
Antiviral therapies are urgently needed to control emerging flaviviruses such as dengue, West Nile, and yellow fever. Ribavirin (RBV) has shown activity against flaviviruses in cultured cells, but efficacy in animal models has generally been poor. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5085be0ef114d6085c59ab8f060797f1
https://doi.org/10.1016/j.antiviral.2010.04.007
https://doi.org/10.1016/j.antiviral.2010.04.007
Autor:
Mohammad Rashidian, Sidath C. Kumarapperuma, Adrian Fegan, Carston R. Wagner, Kari Gabrielse, Mark D. Distefano
Publikováno v:
Journal of the American Chemical Society. 135(44)
Construction of heterofunctional proteins is a rapidly emerging area of biotherapeutics. Combining a protein with other moieties, such as a targeting element, a toxic protein or small molecule, and a fluorophore or polyethylene glycol (PEG) group, ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afb68d0b0d41dd8e51ef3cc644a4be7
https://pubmed.ncbi.nlm.nih.gov/24134212
https://pubmed.ncbi.nlm.nih.gov/24134212