Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sid Sidhu"'
Biased TCR gene usage in alloreactive T cells specific for a structurally dissimilar MHC alloantigen
Autor:
Giovanna Lombardi, Joyce Lynch, Anna George, Sid Sidhu, Francesco Dazzi, Richard Batchelor, Robert I. Lechler, Federica M. Marelli
Publikováno v:
International Immunology. 6:1785-1790
Two models of allorecognition of MHC molecules have been proposed. One emphasizes specificity for MHC molecule-bound peptides and the other for exposed MHC polymorphisms. We predicted that the latter model would predominate in responder:stimulator co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362ca7a14151b6dbdffe4ad3471e0da6
https://doi.org/10.1093/intimm/6.11.1785
https://doi.org/10.1093/intimm/6.11.1785
Autor:
Diana J Watt, Sid Sidhu, Anthony N. Warrens, Giovanna Lombardi, Robert I. Lechler, Jun Yan Zhang, Caroline A Sewry
Publikováno v:
International Immunology. 6:847-853
Recent interest in myoblast transfer and in the use of myoblasts as vehicles in gene therapy has made it important to understand the potential immunogenicity of allogeneic or neoantigen-expressing myoblasts. Given the problems of producing a pure pop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b919eb28796c0d0467b0febca1f570a
https://doi.org/10.1093/intimm/6.6.847
https://doi.org/10.1093/intimm/6.6.847
Publikováno v:
The Journal of Experimental Medicine
The ability of two HLA-DR-expressing human T cell clones to function as antigen-presenting cells (APC) was investigated using highly purified T cells. The results demonstrated that these T cell clones are unable to act as autonomous APC, and that rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793e8eab50ced3051629bfb99c6c3bac
http://europepmc.org/articles/PMC2119371
http://europepmc.org/articles/PMC2119371
Autor:
Sid Sidhu, J. R. Batchelor, G. Lombardi, C. Sharrock, Robert I. Lechler, M. Kevany, C.G. Mackworth-Young
Publikováno v:
Human Immunology. 30:174-182
We describe the generation and characterization of a murine monoclonal antibody with broad anti-HLA-DR beta activity, but which does not recognize DRw11/Dw5. A BALB/c mouse was immunized with a human alloreactive T-cell clone, with the intention of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807be9c12f7bf9fa135ce0cad7e2d4bd
https://doi.org/10.1016/0198-8859(91)90032-5
https://doi.org/10.1016/0198-8859(91)90032-5
Publikováno v:
International Immunology. 2:9-13
Proliferative T cell responses against major histocompatibility complex (MHC) incompatible stimulator cells in the mixed lymphocyte reaction are conventionally regarded as primary. However, it is generally accepted that the recognition of allogeneic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c1608f693914a8cdff19901b1932f8
https://doi.org/10.1093/intimm/2.1.9
https://doi.org/10.1093/intimm/2.1.9
Publikováno v:
Science (New York, N.Y.). 264(5165)
T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37bd3dee154a481bbabef2ac9f3d99c
https://pubmed.ncbi.nlm.nih.gov/7939690
https://pubmed.ncbi.nlm.nih.gov/7939690
Publikováno v:
European journal of immunology. 24(3)
It is well established that triggering interleukin-2 (IL-2) secretion by helper T cells requires the T cell to receive at least two discrete signals. One signal is transduced by the CD3 complex, usually as the result of T cell receptor (TcR) occupanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862cbf9c271cd57c4a652447c9a351c3
https://pubmed.ncbi.nlm.nih.gov/7510233
https://pubmed.ncbi.nlm.nih.gov/7510233
Publikováno v:
Journal of immunological methods. 169(1)
Alloreactive human T cells are conventionally generated in vitro using peripheral blood mononuclear cells (PBMCs). The disadvantage of such an approach is that PBMCs express multipl HLA class II molecules and, as a consequence, it is difficult to gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7888aaff4e84092c38d403198e0c87f5
https://pubmed.ncbi.nlm.nih.gov/7907639
https://pubmed.ncbi.nlm.nih.gov/7907639
Autor:
Robert I. Lechler, Giovanna Lombardi, Richard Batchelor, John Goldmann, Tony Schwarer, Sarah Deacock, Sid Sidhu
Publikováno v:
Progress in Immunology Vol. VIII ISBN: 9783642514814
The capacity of T lymphocytes to respond vigorously to allogeneic tissues has always represented the major obstacle to successful tissue transplantation. This obstacle is usually overcome in solid organ allografting by means of powerful immunosuppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a40a04608fc2e6bd5070a068f93eab
https://doi.org/10.1007/978-3-642-51479-1_101
https://doi.org/10.1007/978-3-642-51479-1_101
Publikováno v:
International immunology. 3(8)
The separate contributions to allorecognition of peptide-binding and T cell receptor-contacting residues of an allogeneic HLA-DR molecule were investigated by site-directed mutagenesis. Alloreactive T cell clones were generated from a combination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baffff8181db6a4339140afdb8ccafd6
https://pubmed.ncbi.nlm.nih.gov/1911546
https://pubmed.ncbi.nlm.nih.gov/1911546