Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sid Dempsey"'
Autor:
Sid Dempsey, Carole Cairns, Paul S. Collier, Anthony McCarthy, James McElnay, Jeffrey S. Millership, Ahmed F. Hawwa
Publikováno v:
European Journal of Clinical Pharmacology. 65:1105-1112
To develop a method that prospectively assesses adherence rates in paediatric patients with acute lymphoblastic leukaemia (ALL) who are receiving the oral thiopurine treatment 6-mercaptopurine (6-MP). A total of 19 paediatric patients with ALL who we
Autor:
Ahmed F. Hawwa, Anthony McCarthy, Paul S. Collier, Jeffrey S. Millership, James McElnay, Carole Cairns, Sid Dempsey
Publikováno v:
British Journal of Clinical Pharmacology. 66:826-837
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The cytotoxic effects of 6-mercaptopurine (6-MP) were found to be due to drug-derived intracellular metabolites (mainly 6-thioguanine nucleotides and to some extent 6-methylmercaptopurine nucleotides) rath
Autor:
James McElnay, Paul S. Collier, Anthony McCarthy, Ahmed F. Hawwa, John Collins, Carole Cairns, Sid Dempsey, Colin Rodgers, Jeffrey S. Millership, Koen Vandenbroeck
Publikováno v:
British journal of clinical pharmacology. 66(4)
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • 6-Mercaptopurine (6-MP) and azathioprine (AZA) are both inactive prodrugs that require intracellular activation into the active 6-thioguanine nucleotides (6-TGNs). • This metabolic process undergoes thre
Autor:
Vas Novelli, Denis O’Hara, Anita E. Smyth, Emmanuelle Jouanguy, Jon Pritchard, Sid Dempsey, Rosie Hague, J. David M. Edgar, Allister J. Taggart, Louise Sweeney, Dinakantha S. Kumararatne, David A. Lammas, Jean-Laurent Casanova
Publikováno v:
The Journal of pediatrics. 139(4)
Two patients who were initially given a diagnosis of Langerhans' cell histiocytosis on the basis of the clinical, radiologic, and biopsy findings had mycobacterial infection subsequently identified. The correct diagnosis of dominant partial interfero