Výsledky vyhledávání - "Sid D. Nelson"

Mechanistic studies of the cationic binding pocket of CYP2C9 in vitro and in silico: metabolism of nonionizable analogs of tienilic acid

Autor: Sid D. Nelson, Hoa Le, Kevin A. Ford, S. Cyrus Khojasteh, Suzanne Tay, Peter M. Rademacher

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 42(11)

Tienilic acid (TA) is selectively oxidized at the C-5 position of the thiophene ring by the human liver enzyme cytochrome P450 2C9 (CYP2C9). This oxidation is mediated by the proximal positioning of the thiophene over the heme iron, which is proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76daef682834879f482c37a9c52e56e
https://pubmed.ncbi.nlm.nih.gov/25187484

Zobrazit plný text záznamu

Peroxidase-catalyzed oxidation of 3,5-dimethyl acetaminophen causes cell death by selective protein thiol modification in isolated rat hepatocytes

Autor: Marianne Weis, Mats Rundgren, Sid D. Nelson, Peter Moldéus

Publikováno v: Chemico-biological interactions. 100(3)

In this study we used a peroxidase model system (glucose/glucose oxidase and horseradish peroxidase) to investigate the effect of extracellularly generated reactive metabolites of 3,5-Me2-acetaminophen on cell viability and on cellular thiol levels.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d3e1436c8dae355d350b267a1fcf57
https://pubmed.ncbi.nlm.nih.gov/8653807

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání