Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sichun Lin"'
Autor:
Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract The release of Ca2+ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca2+ often occurs through inositol 1,4,5-triphos
Externí odkaz:
https://doaj.org/article/621bb704143344139070befe42b1c5d8
Autor:
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA polymerase II (Pol II), and t
Externí odkaz:
https://doaj.org/article/29852213a0ff4f3898e31bb9afc0393f
Autor:
Thibault Houles, Geneviève Lavoie, Sami Nourreddine, Winnie Cheung, Éric Vaillancourt-Jean, Célia M. Guérin, Mathieu Bouttier, Benoit Grondin, Sichun Lin, Marc K. Saba-El-Leil, Stephane Angers, Sylvain Meloche, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target whic
Externí odkaz:
https://doaj.org/article/875e347a38ed42f697dc3427cce904d4
Autor:
Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K. Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J. Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P. Roux
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The oncogene KRAS is frequently mutated in cancer, including colorectal cancer. Here, using a cell-surface proteomics approach, KRAS-mutated colorectal cancer cells are shown to express high levels of the copper transporter ATP7A, which has an essent
Externí odkaz:
https://doaj.org/article/e0ea73c88dab4e7c804e408236956ef7
Autor:
John D. Laver, Jimmy Ly, Allison K. Winn, Angelo Karaiskakis, Sichun Lin, Kun Nie, Giulia Benic, Nima Jaberi-Lashkari, Wen Xi Cao, Alireza Khademi, J. Timothy Westwood, Sachdev S. Sidhu, Quaid Morris, Stephane Angers, Craig A. Smibert, Howard D. Lipshitz
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3353-3367.e7 (2020)
Summary: G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray anal
Externí odkaz:
https://doaj.org/article/9faf1f277a61420f88079b33d872a60a
Autor:
Zongjie Wang, Hansen Wang, Sichun Lin, Mahmoud Labib, Sharif Ahmed, Jagotamoy Das, Stephane Angers, Edward H. Sargent, Shana O. Kelley
Publikováno v:
Nano Letters.
Autor:
Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
Publikováno v:
EMBO reports. 23
Autor:
Siobhan, O'Brien, Susan, Kelso, Zachary, Steinhart, Stephen, Orlicky, Monika, Mis, Yunhye, Kim, Sichun, Lin, Frank, Sicheri, Stephane, Angers
Publikováno v:
EMBO reports. 23(12)
FBXW7, which encodes a substrate-specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using
Autor:
Siobhan O’Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers
FBXW7, which encodes a substrate specific receptor of an SCF E3 ligase complex, is a frequently mutated human tumor suppressor gene known to regulate the post-translational stability of various proteins involved in cellular proliferation. Here, using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564a9c72f6688e308a6e716fadfadfe0
https://doi.org/10.1101/2022.09.26.509608
https://doi.org/10.1101/2022.09.26.509608
Autor:
Fan, Xia, Yuan, Ma, Kangfu, Chen, Bill, Duong, Sharif, Ahmed, Randy, Atwal, David, Philpott, Troy, Ketela, Jennifer, Pantea, Sichun, Lin, Stephane, Angers, Shana O, Kelley
Publikováno v:
Science advances. 8(35)
Circulating tumor cells (CTCs) break free from primary tumors and travel through the circulation system to seed metastatic tumors, which are the major cause of death from cancer. The identification of the major genetic factors that enhance production