Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sichun, Zhou"'
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-14 (2022)
Abstract A major reason for the high mortality of patients with bladder cancer (BC) is that chemotherapy and surgery are only effective for very limited patients. Thus, developing novel treatment options becomes an urgent need for improving clinical
Externí odkaz:
https://doaj.org/article/6ea2df3fd7de4c3c925d039d0664cc11
Autor:
Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li
Publikováno v:
FEBS Open Bio, Vol 11, Iss 5, Pp 1440-1451 (2021)
Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator m
Externí odkaz:
https://doaj.org/article/69f502533777459f93cdae3f72fa57d3
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/7bf1a4ad493f43e3b706a7b75871a143
Autor:
Yanjun Huang, Sichun Zhou, Caimei He, Jun Deng, Ting Tao, Qiongli Su, Kwame Oteng Darko, Mei Peng, Xiaoping Yang
Publikováno v:
Cancer Communications, Vol 38, Iss 1, Pp 1-14 (2018)
Abstract Background In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or in combination with g
Externí odkaz:
https://doaj.org/article/d94918f555354fc1943f499ad88f4470
Autor:
Wei, Wang, Di, Xiao, Sichun, Zhou, Simeng, Xu, Xinyi, Tang, Xinchong, Zhou, Jinbing, Liu, Cangcang, Xu, Mei, Peng, Xiaoping, Yang
Publikováno v:
Medicinal Chemistry. 18:895-902
Background: In recent years, the anticancer effects of biguanide drugs have received considerable attention. However, the effective concentration of biguanide drugs to kill cancer cells is relatively high. Thus, we focus on structural modification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1028ff9bf4beaa3dd409ef420fe4ce17
https://doi.org/10.2174/1573406418666220210111458
https://doi.org/10.2174/1573406418666220210111458
Autor:
Mei Peng, Jun Deng, Sichun Zhou, Di Xiao, Jiahui Long, Nan Zhang, Caimei He, Miao Mo, Xiaoping Yang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems. In this study, we found that pirarubicin (THP), one imp
Externí odkaz:
https://doaj.org/article/fe402411fee54249ab39f8163439cfa2
Autor:
Sichun, Zhou, Duo, Li, Di, Xiao, Tianyu, Wu, Xin, Hu, Yu, Zhang, Jun, Deng, Jing, Long, Simeng, Xu, Jingtao, Wu, Gaofeng, Li, Mei, Peng, Xiaoping, Yang
Publikováno v:
International Journal of Biological Sciences. 18:1555-1568
Poly (ADP-ribose) polymerase inhibitors (PARPi) have showed clinical benefit as maintenance therapy in advanced ovarian cancer by impairing the homologous recombination (HR) pathway. Pyruvate kinase M2 (PKM2), the significant cancer metabolic biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1ef76609223bc820ce14c970daa1b5
https://doi.org/10.7150/ijbs.62947
https://doi.org/10.7150/ijbs.62947
Autor:
Xin Hu, Caimei He, Xiaoping Yang, Di Xiao, Simeng Xu, Yanjun Huang, Jingtao Wu, Mei Peng, Sichun Zhou, Jun Deng
Publikováno v:
Food Science & Nutrition
Food Science & Nutrition, 8(4):1942-1948
Food Science & Nutrition, Vol 8, Iss 4, Pp 1942-1948 (2020)
Food Science & Nutrition, 8(4):1942-1948
Food Science & Nutrition, Vol 8, Iss 4, Pp 1942-1948 (2020)
Vitamin A (VA) is one of the most widely used food supplements, but its molecular mechanisms largely remain elusive. Previously, we have demonstrated that VA inhibits the action of lipopolysaccharide (LPS) on intestinal epithelial barrier function an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa97533f529becfd1d377ff4a314e38e
https://doi.org/10.1002/fsn3.1481
https://doi.org/10.1002/fsn3.1481
Autor:
Yanjun Huang, Caimei He, Zheng Hu, Xuetong Chu, Sichun Zhou, Xin Hu, Jun Deng, Di Xiao, Ting Tao, Huansheng Yang, Alex F. Chen, Yulong Yin, Xiaoping Yang
Alpha (α)-tocopherol is a major component of dietary vitamin E. Despite being one of the most widely used food supplements in both animals and humans, its role in intestinal functions remains unknown. We were able to examine and accurately demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f3e94a070b9de45d0aaf11bada3459
https://repository.publisso.de/resource/frl:6452987
https://repository.publisso.de/resource/frl:6452987
Publikováno v:
Cell deathdisease. 13(5)
A major reason for the high mortality of patients with bladder cancer (BC) is that chemotherapy and surgery are only effective for very limited patients. Thus, developing novel treatment options becomes an urgent need for improving clinical outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbd9f22e32cc73e6e83ec30e0d1322b
https://pubmed.ncbi.nlm.nih.gov/35614042
https://pubmed.ncbi.nlm.nih.gov/35614042