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Akademický článek

Presenilin-1 Mutations Sensitize Neurons to DNA Damage-Induced Death by a Mechanism Involving Perturbed Calcium Homeostasis and Activation of Calpains and Caspase-12

Autor: Sic L. Chan, Carsten Culmsee, Norman Haughey, Wolfram Klapper, Mark P. Mattson

Publikováno v: Neurobiology of Disease, Vol 11, Iss 1, Pp 2-19 (2002)

Mutations in presenilin-1 (PS1) can cause early onset familial Alzheimer's disease (AD). Studies of cultured cells and mice expressing mutant PS1 suggest that PS1 mutations may promote neuronal dysfunction and degeneration by altering cellular calciu

Externí odkaz: https://doaj.org/article/1ce97aee43e04d2eb769e1ae10716cd5

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Data from Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness

Autor: Sic L. Chan, Jeremy N. Rich, Justin D. Lathia, Sergey Bushnev, Kiminobu Sugaya, George A. Kyriazis, Jogi V. Pattisapu, Leena Paul, Meenu Madan, Anusha Naganathan, Daniel Barrera, Rajarajeswari Venkataraman, Srinivasulu Chigurupati

Glioblastoma multiforme (GBM) is the most frequent and incurable type of brain tumor of adults. Hypoxia has been shown to direct GBM toward a more aggressive and malignant state. Here we show that hypoxia increases Notch1 activation, which in turn in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3ad24273bfcac8b4a028dc6e3d88263
https://doi.org/10.1158/0008-5472.c.6500366

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Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein

Autor: Sic L. Chan, Amin Yu, Jogi V. Pattisapu, Yoonsuk Cho, Dong-Gyu Jo, Srinivasulu Chigurupati, Seung Hyun Baek, Mark P. Mattson, Jinsu Park, Mohamed R Mughal, Meenu Madan

Publikováno v: J Gerontol A Biol Sci Med Sci

The accumulation of amyloid-β (Aβ) is a characteristic event in the pathogenesis of Alzheimer’s disease (AD). Aquaporin 1 (AQP1) is a membrane water channel protein belonging to the AQP family. AQP1 levels are elevated in the cerebral cortex duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d9511c5e0c5869cec271b82f569ea5
https://europepmc.org/articles/PMC7756701/

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Akademický článek

A synthetic uric acid analog accelerates cutaneous wound healing in mice.

Autor: Srinivasulu Chigurupati, Mohamed R Mughal, Sic L Chan, Thiruma V Arumugam, Akanksha Baharani, Sung-Chun Tang, Qian-Sheng Yu, Harold W Holloway, Ross Wheeler, Suresh Poosala, Nigel H Greig, Mark P Mattson

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10044 (2010)

Wound healing is a complex process involving intrinsic dermal and epidermal cells, and infiltrating macrophages and leukocytes. Excessive oxidative stress and associated inflammatory processes can impair wound healing, and antioxidants have been repo

Externí odkaz: https://doaj.org/article/b74c5a2aed3646e7a3fc157c369f2cb9

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Deletion of TRPC6 Attenuates NMDA Receptor-Mediated Ca2+ Entry and Ca2+-Induced Neurotoxicity Following Cerebral Ischemia and Oxygen-Glucose Deprivation

Autor: Jin Chen, Jeffery T. Hatcher, Robert D. Wurster, Zhaozhong Li, Li Chen, Qing-Hui Chen, Zixi Cheng, Sic L. Chan

Publikováno v: Frontiers in Neuroscience

Transient receptor potential canonical 6 (TRPC6) channels are permeable to Na+ and Ca2+ and are widely expressed in the brain. In this study, the role of TRPC6 was investigated following ischemia/reperfusion (I/R) and oxygen-glucose deprivation (OGD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964080070dd5edcd0acfefbd310d3168
https://doi.org/10.3389/fnins.2017.00138

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