Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sibylle Wenzel"'
Publikováno v:
Molecular medicine reports. 17(6)
The hazards of granular and fibrous particles have been associated with the generation of reactive oxygen species (ROS), which in turn is often associated with physicochemical properties exhibited by these particles. In the present study, the ability
Autor:
Simone Helmig, Reginald Matejec, Markus A. Weigand, Hagen Maxeiner, Friederike Dülfer, Joachim Schneider, Andreas Böning, Sibylle Wenzel, Nina Krehbiehl, Solaiman Mufti, Klaus-Dieter Schlüter
Publikováno v:
Journal of Cellular Physiology. 229:1681-1689
Cardiosphere-derived cells (CDCs) were cultured from human, murine, and rat hearts. Diluted supernatant (conditioned-medium) of the cultures improved the contractile behavior of isolated rat cardiomyocytes (CMCs). This effect is mediated by the parac
Publikováno v:
Mutagenesis. 29:237-240
Benzo(a)pyrene (BaP), a primary component of tobacco smoke, is activated by cytochrome P450 1B1 (CYP1B1). Smokers homozygous for the C-allele (*1/*1) at the CYP1B1 Leu432Val polymorphism have shown increased CYP1B1 expression, compared to smokers hom
Publikováno v:
Molecular Medicine Reports. 9:217-228
Natural and synthetic fibres and particles are being introduced into the workplace and environment daily. Comparative analyses of the induced signalling pathways are essential in order to understand the potential hazards of these particles. To identi
Autor:
Evren Caglayan, Stephan Rosenkranz, Rolf Schreckenberg, Gerhild Euler, Christoph Arens, Michael Bader, Jacqueline Heger, Sibylle Wenzel, Klaus-Dieter Schlüter, Söhnke Hinrichs
Publikováno v:
Cardiovascular Research. 89:344-352
Aims Renin and peroxisome proliferator-activated receptor (PPAR-γ) interact directly with cardiomyocytes and influence protein synthesis. We investigated their effects and interaction on the size of cardiomyocytes. Methods and results Effects of ren
Autor:
Klaus-Dieter Schlüter, Rui Manuel da Costa Rebelo, Rolf Schreckenberg, Rainer Meyer, Anja Röthig, Sibylle Wenzel
Publikováno v:
Endocrinology. 150:3735-3741
The missing influence of estrogen on endothelial nitric oxide (NO) synthase often forms the basis for a worsening of the cardiac risk profile for women in postmenopause. Various studies have shown that decreasing estrogen levels also directly effect
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 451:328-337
Besides the classical cardiovascular diseases, high levels of blood glucose directly interfere with cardiomyocytes. The mechanisms responsible for this have not yet been explored in detail. This study aims to determine if hyperglycaemia has any impac
Autor:
Heike Degenhardt, Klaus-Dieter Schlüter, Rainer Meyer, Martin van Eickels, Sibylle Wenzel, Marcus P. Heinemann, Pieter A. Doevendans, Christian Grohé, Günter Ross
Publikováno v:
Cardiovascular Research. 61:307-316
Objective: Parathyroid hormone-related peptide (PTHrP) expression is modulated by estrogen. It is expressed in coronary endothelial cells and involved in the endothelium-dependent regulation of coronary resistance and cardiac function. In the present
Autor:
Heike Degenhardt, Karen Frischkopf, Stephan Rosenkranz, Hans Michael Piper, Rudolf J. Wiesner, Klaus-Dieter Klaus-Dieter, Georg Kojda, Katja Schorr, Sibylle Wenzel
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:1181-1190
Parathyroid hormone-related peptide (PTHrP) is expressed throughout the cardiovascular system including coronary endothelial cells. Factors involved in the regulation of cardiac PTHrP expression have not been examined before. This study investigates
Autor:
H. M. Piper, Gerhild Taimor, Karen Frischkopf, C. Katzer, Sibylle Wenzel, Klaus-Dieter Schlüter
Publikováno v:
Circulation Research. 86:946-951
Abstract —Ventricular cardiomyocytes have previously been identified as potential target cells for parathyroid hormone–related peptide (PTHrP). Synthetic PTHrP peptides exert a positive contractile effect. Because systemic PTHrP levels are normal