Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sibylle, Sax"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Antimalarial resistance to the first-line partner drug piperaquine (PPQ) threatens the effectiveness of artemisinin-based combination therapy. In vitro piperaquine resistance is characterized by incomplete growth inhibition, i.e. increased parasite g
Externí odkaz:
https://doaj.org/article/c86a51b4ecc24b17b0c575f258d5446c
Autor:
Nina Vahekeni, Théo Brillatz, Marjan Rahmaty, Monica Cal, Sonja Keller-Maerki, Romina Rocchetti, Marcel Kaiser, Sibylle Sax, Kevin Mattli, Evelyn Wolfram, Laurence Marcourt, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pascal Mäser
Publikováno v:
Molecules, Vol 29, Iss 7, p 1611 (2024)
Folk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants a
Externí odkaz:
https://doaj.org/article/af4925c1057c4951af249559e86d85a1
Autor:
Annabelle Walz, Maëlle Duffey, Ghaith Aljayyoussi, Sibylle Sax, Didier Leroy, Dominique Besson, Jeremy N. Burrows, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Marie-Anne Westwood, Christoph Siethoff, Francisco-Javier Gamo, Pascal Mäser, Sergio Wittlin
Publikováno v:
Pharmaceuticals, Vol 16, Iss 2, p 163 (2023)
With artemisinin-resistant Plasmodium falciparum parasites emerging in Africa, the need for new antimalarial chemotypes is persistently high. The ideal pharmacodynamic parameters of a candidate drug are a rapid onset of action and a fast rate of para
Externí odkaz:
https://doaj.org/article/ed61e47142b2471096b9a830abacea17
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Martijn W. Vos, Manuel Llinás, Floris P. J. T. Rutjes, Sergio Wittlin, Gabrielle A. Josling, Iñigo Angulo-Barturen, Stacy A. Reeves, Julie M. J. Verhoef, Karin M. J. Koolen, Erik L. Allman, Karen Miller, Helmi Pett, Suzanne Jackowski, Judith M. Bolscher, Robert W. Sauerwein, L. E. De Vries, María Belén Jiménez-Díaz, Richard H. Blaauw, Peter N. M. Botman, Graham P. Trevitt, Christien A. Beuckens-Schortinghuis, Brice Campo, Christian Scheurer, Sibylle Sax, Koen J. Dechering, Pedro H. H. Hermkens, Roger Bonnert, Christoph Fischli, Joost Schalkwijk
Publikováno v:
Science Translational Medicine. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6549a95b6758c0507a3f1f8b74eaf188
https://doi.org/10.1126/scitranslmed.abg8900
https://doi.org/10.1126/scitranslmed.abg8900
Autor:
Patrick A. M. Jansen, Taco W. A. Kooij, Helmi Pett, Judith M. Bolscher, Suzanne Jackowski, Laura E. de Vries, María Belén Jiménez-Díaz, Brice Campo, Martijn W. Vos, Karin M. J. Koolen, Roger Bonnert, Stacy A. Reeves, Christoph Fischli, Christien A. Beuckens-Schortinghuis, Peter N. M. Botman, Koen J. Dechering, Manuel Llinás, Gabrielle A. Josling, Robert W. Sauerwein, Joost Schalkwijk, Julie M. J. Verhoef, Sergio Wittlin, Karen Miller, Pedro H. H. Hermkens, Graham P. Trevitt, Iñigo Angulo-Barturen, Erik L. Allman, Floris P. J. T. Rutjes, Richard H. Blaauw, Christian Scheurer, Sibylle Sax
Publikováno v:
Science Translational Medicine, 11(510)
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Science Translational Medicine, 11, 510, pp. 1-16
Science Translational Medicine, 11, 1-16
Science Translational Medicine 11 (2019) 510
Malaria eradication is critically dependent on new therapeutics that target resistant Plasmodium parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage Plasmodium falciparum p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef5f25c8bda84ba537ac40b18f93959
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
https://research.wur.nl/en/publications/antimalarial-pantothenamide-metabolites-target-acetyl-coenzyme-a-
Autor:
Robert W. Sauerwein, Christoph Fischli, Suzanne Jackowski, Koen J. Dechering, Floris P. J. T. Rutjes, Martijn W. Vos, Christian Scheurer, Helmi Pett, Stacy A. Reeves, Sibylle Sax, Laura E. de Vries, Pedro H. H. Hermkens, Gabrielle A. Josling, Richard H. Blaauw, Sergio Wittlin, Erik L. Allman, Karin M. J. Koolen, Roger Bonnert, Christien A. Beuckens-Schortinghuis, Peter N. M. Botman, Joost Schalkwijk, Brice Campo, Karen Miller, Judith M. Bolscher, Patrick A. M. Jansen, Taco W. A. Kooij, Manuel Llinás, Graham P. Trevitt
Malaria eradication is critically dependent on novel drugs that target resistantPlasmodiumparasites and block transmission of the disease. Here we report the discovery of potent pantothenamide bioisosteres that are active against blood-stageP. falcip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a7559646b6be9035b4dd72ab909023
https://doi.org/10.1101/256669
https://doi.org/10.1101/256669
Autor:
Joost, Schalkwijk, Erik L, Allman, Patrick A M, Jansen, Laura E, de Vries, Julie M J, Verhoef, Suzanne, Jackowski, Peter N M, Botman, Christien A, Beuckens-Schortinghuis, Karin M J, Koolen, Judith M, Bolscher, Martijn W, Vos, Karen, Miller, Stacy A, Reeves, Helmi, Pett, Graham, Trevitt, Sergio, Wittlin, Christian, Scheurer, Sibylle, Sax, Christoph, Fischli, Iñigo, Angulo-Barturen, Mariá Belén, Jiménez-Diaz, Gabrielle, Josling, Taco W A, Kooij, Roger, Bonnert, Brice, Campo, Richard H, Blaauw, Floris P J T, Rutjes, Robert W, Sauerwein, Manuel, Llinás, Pedro H H, Hermkens, Koen J, Dechering
Publikováno v:
Science translational medicine. 11(510)
Malaria eradication is critically dependent on new therapeutics that target resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::841dc2b1d75efe5c50f2f7949ba194d8
https://pubmed.ncbi.nlm.nih.gov/33568524
https://pubmed.ncbi.nlm.nih.gov/33568524
Autor:
Natalie E. Hofmann, Sibylle Sax, Shivendra Singh, Thomas Spangenberg, Kathryn J. Wicht, Donelly A. van Schalkwyk, Christian Scheurer, Stephen G. Oliver, Anil Sharma, Hans-Peter Beck, Sergio Wittlin, Colin J. Sutherland, Monika Chugh, Pawan Malhotra, Sridevi Bashyam, Xavier C. Ding, Elizabeth Bilsland, Timothy J. Egan
Plasmodium falciparum , the most deadly agent of malaria, displays a wide variety of resistance mechanisms in the field. The ability of antimalarial compounds in development to overcome these must therefore be carefully evaluated to ensure uncompromi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e6806fc16d604c89ebb3faac3c511e
https://europepmc.org/articles/PMC4335906/
https://europepmc.org/articles/PMC4335906/
Autor:
Serena Tschan, Benjamin Mordmüller, Jolanda Kamber, Detlef Geffken, Sandra Duffy, Sergio Wittlin, Christoph Siethoff, Walter Frank, Sibylle Sax, Michael Leven, Thomas Kurz, Stéphane Barth, Krystina Kuna, Vicky M. Avery, Jana Held
Publikováno v:
Journal of medicinal chemistry. 57(19)
3-Hydroxy-N'-arylidenepropanehydrazonamides represent a new class of antiplasmodial compounds. The two most active phenanthrene-based derivatives showed potent in vitro antiplasmodial activity against the 3D7 (sensitive) and Dd2 (multidrug-resistant)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98e48174ced74eee3d87f9234d42956
https://pubmed.ncbi.nlm.nih.gov/25195945
https://pubmed.ncbi.nlm.nih.gov/25195945
Autor:
Didier Leroy, Sergio Wittlin, Yassir Younis, Sarah Schleiferbock, Pete Smith, Christian Scheurer, Diego Gonzàlez Cabrera, Kelly Chibale, Michael J Witty, Leslie J. Street, Claire Le Manach, Tanya Paquet, Xavier C. Ding, David Waterson, Sibylle Sax
Publikováno v:
Malaria Journal
BACKGROUND: Recent whole cell in vitro screening campaigns identified thousands of compounds that are active against asexual blood stages of Plasmodium falciparum at submicromolar concentrations. These hits have been made available to the public, pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7faf02c25667d3ca07062fab4c3570
https://doi.org/10.1186/1475-2875-12-424
https://doi.org/10.1186/1475-2875-12-424