Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models.

Autor: Siboni RB; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA., Nakamori M; Department of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan., Wagner SD; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA., Struck AJ; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA., Coonrod LA; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA., Harriott SA; Department of Chemistry, Reed College, Portland, OR 97202, USA., Cass DM; Department of Chemistry, Reed College, Portland, OR 97202, USA., Tanner MK; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA., Berglund JA; Institute of Molecular Biology and Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR 97403, USA; Department of Biochemistry & Molecular Biology, Center for NeuroGenetics, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: aberglund@ufl.edu.

Publikováno v: Cell reports [Cell Rep] 2015 Dec 22; Vol. 13 (11), pp. 2386-2394. Date of Electronic Publication: 2015 Dec 10.

Reducing levels of toxic RNA with small molecules.

Autor: Coonrod LA; Institute of Molecular Biology and §Department of Chemistry and Biochemistry, University of Oregon , Eugene, Oregon 97403, United States., Nakamori M, Wang W, Carrell S, Hilton CL, Bodner MJ, Siboni RB, Docter AG, Haley MM, Thornton CA, Berglund JA

Publikováno v: ACS chemical biology [ACS Chem Biol] 2013 Nov 15; Vol. 8 (11), pp. 2528-37. Date of Electronic Publication: 2013 Sep 27.