Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Autor: den Hoed, M, Eijgelsheim, M, Esko, T, Brundel, Bj, Peal, Ds, Evans, Dm, Nolte, Im, Segrè, Av, Holm, H, Handsaker, Re, Westra, Hj, Johnson, T, Isaacs, A, Yang, J, Lundby, A, Zhao, Jh, Kim, Yj, Go, Mj, Almgren, P, Bochud, M, Boucher, G, Cornelis, Mc, Gudbjartsson, D, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, Au, Kutalik, Z, Luan, J, Kemp, Jp, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, Me, Njajou, Ot, O'Reilly, Pf, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, Nj, Vitart, V, Waite, L, Wheeler, W, Zhang, W, Draisma, Hh, Feitosa, Mf, Kerr, Kf, Lind, Pa, Mihailov, E, Onland Moret NC, Song, C, Weedon, Mn, Xie, W, Yengo, L, Absher, D, Albert, Cm, Alonso, A, Arking, De, de Bakker PI, Balkau, B, Barlassina, C, Benaglio, P, Bis, Jc, Bouatia Naji, N, Brage, S, Chanock, Sj, Chines, Ps, Chung, M, Darbar, D, Dina, C, Dörr, M, Elliott, P, Felix, Sb, Fischer, K, Fuchsberger, C, de Geus EJ, Goyette, P, Gudnason, V, Harris, Tb, Hartikainen, Al, Havulinna, As, Heckbert, Sr, Hicks, Aa, Hofman, A, Holewijn, S, Hoogstra Berends, F, Hottenga, Jj, Jensen, Mk, Johansson, A, Junttila, J, Kääb, S, Kanon, B, Ketkar, S, Khaw, Kt, Knowles, Jw, Kooner, As, Kors, Ja, Kumari, M, Milani, L, Laiho, P, Lakatta, Eg, Langenberg, C, Leusink, M, Liu, Y, Luben, Rn, Lunetta, Kl, Lynch, Sn, Markus, Mr, Marques Vidal, P, Mateo Leach, I, Mcardle, Wl, Mccarroll, Sa, Medland, Se, Miller, Ka, Montgomery, Gw, Morrison, Ac, Müller Nurasyid, M, Navarro, P, Nelis, M, O'Connell, Jr, O'Donnell, Cj, Ong, Kk, Newman, Ab, Peters, A, Polasek, O, Pouta, A, Pramstaller, Pp, Psaty, Bm, Rao, Dc, Ring, Sm, Rossin, Ej, Rudan, D, Sanna, S, Scott, Ra, Sehmi, Js, Sharp, S, Shin, Jt, Singleton, Ab, Smith, Av, Soranzo, N, Spector, Td, Stewart, C, Stringham, Hm, Tarasov, Kv, Uitterlinden, Ag, Vandenput, L, Hwang, Sj, Whitfield, Jb, Wijmenga, C, Wild, Sh, Willemsen, G, Wilson, Jf, Witteman, Jc, Wong, A, Wong, Q, Jamshidi, Y, Zitting, P, Boer, Jm, Boomsma, Di, Borecki, Ib, van Duijn CM, Ekelund, U, Forouhi, Ng, Froguel, P, Hingorani, A, Ingelsson, E, Kivimaki, M, Kronmal, Ra, Kuh, D, Lind, L, Martin, Ng, Oostra, Ba, Pedersen, Nl, Quertermous, T, Rotter, Ji, van der Schouw YT, Verschuren, Wm, Walker, M, Albanes, D, Arnar, Do, Assimes, Tl, Bandinelli, S, Boehnke, M, de Boer RA, Bouchard, C, Caulfield, Wl, Chambers, Jc, Curhan, G, Cusi, D, Eriksson, J, Ferrucci, L, van Gilst WH, Glorioso, N, de Graaf, J, Groop, L, Gyllensten, U, Hsueh, Wc, Hu, Fb, Huikuri, Hv, Hunter, Dj, Iribarren, C, Isomaa, B, Jarvelin, Mr, Jula, A, Kähönen, M, Kiemeney, La, van der Klauw MM, Kooner, Js, Kraft, P, Iacoviello, Licia, Lehtimäki, T, Lokki, Ml, Mitchell, Bd, Navis, G, Nieminen, Ms, Ohlsson, C, Poulter, Nr, Qi, L, Raitakari, Ot, Rimm, Eb, Rioux, Jd, Rizzi, F, Rudan, I, Salomaa, V, Sever, Ps, Shields, Dc, Shuldiner, Ar, Sinisalo, J, Stanton, Av, Stolk, Rp, Strachan, Dp, Tardif, Jc, Thorsteinsdottir, U, Tuomilehto, J, van Veldhuisen DJ, Virtamo, J, Viikari, J, Vollenweider, P, Waeber, G, Widen, E, Cho, Ys, Olsen, Jv, Visscher, Pm, Willer, C, Franke, L, Global BPgen Consortium, Cardiogram, Consortium, Erdmann, J, Thompson, Jr, PR GWAS Consortium, Pfeufer, A, QRS GWAS Consortium, Sotoodehnia, N, QT IGC Consortium, Newton Cheh, C, CHARGE AF Consortium, Ellinor, Pt, Stricker, Bh, Metspalu, A, Perola, M, Beckmann, Js, Smith, Gd, Stefansson, K, Wareham, Nj, Munroe, Pb, Sibon, Oc, Milan, Dj, Snieder, H, Samani, Nj, Loos, R. J.

Publikováno v: den Hoed, M, Eijgelsheim, M, Esko, T, Brundel, B J J M, Peal, D S, Evans, D M, Nolte, I M, Segrè, A V, Holm, H, Handsaker, R E, Westra, H-J, Johnson, T, Isaacs, A, Yang, J, Lundby, A, Zhao, J H, Kim, Y J, Go, M J, Almgren, P, Bochud, M, Boucher, G, Cornelis, M C, Gudbjartsson, D, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, A U, Kutalik, Z, Luan, J, Kemp, J P, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, M E, Njajou, O T, O'Reilly, P F, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, N J, Vitart, V, Navarro, P, Polasek, O, Wild, S H & Wilson, J F & Rudan, I 2013, ' Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders ', Nature Genetics, vol. 45, no. 6, pp. 621-. https://doi.org/10.1038/ng.2610
Nature Genetics, vol. 45, no. 6, pp. 621-631
Nature Genetics, 45(6), 621-631. Nature Publishing Group
Nature Genetics, 45(6), 621-31. Nature Publishing Group
Nature Genetics, 45, 621-31
Nature Genetics, 45(6), 621-+. Nature Publishing Group
Nature Genetics, 45, 6, pp. 621-31
den Hoed, M A H, Eijgelsheim, M, Esko, T, Brundel, B J, Peal, D S, Evans, D M, Nolte, I M, Segrè, A V, Holm, H, Handsaker, R E, Westra, H J, Johnson, T, Isaacs, A, Yang, L, Lundby, A, Zhao, J H, Kim, Y J, Go, M J, Almgren, P, Bochud, M, Boucher, G, Cornelis, M C, Gudbjartsson, D F, Hadley, D, van der Harst, P, Hayward, C, den Heijer, M, Igl, W, Jackson, A U, Kutalik, Z, Luan, J, Kemp, J P, Kristiansson, K, Ladenvall, C, Lorentzon, M, Montasser, M E, Njajou, O T, O'Reilly, P F, Padmanabhan, S, St Pourcain, B, Rankinen, T, Salo, P, Tanaka, T, Timpson, N J, Vitart, V, Waite, L, Wheeler, W, Zhang, W, Draisma, H H M, Feitosa, M F, Kerr, K F, Lind, P A, Mihailov, E, Onland-Moret, N C, Song, C, Weedon, M N, Xie, W, Yengo, L, Absher, D, Albert, C M, Alonso, A, Arking, D E, de Bakker, P I, Balkau, B, Barlassina, C, Benaglio, P, Bis, J C, Bouatia-Naji, N, Brage, S, Chanock, S J, Chines, P S, Chung, M, Darbar, D, Dina, C, Dörr, M, Elliott, P, Felix, S B, Fischer, K, Fuchsberger, C, de Geus, E J C, Goyette, P, Gudnason, V, Harris, T B, Hartikainen, A L, Havulinna, A S, Heckbert, S R, Hicks, A A, Hofman, A, Holewijn, S, Hoogstra-Berends, F, Hottenga, J J, Jensen, M K, Johansson, A, Junttila, J, Kääb, S, Kanon, B, Ketkar, S, Khaw, K T, Knowles, J W, Kooner, A S, Kors, J A, Kumari, M, Milani, L, Laiho, P, Lakatta, E G, Langenberg, C, Leusink, M, Liu, Y, Luben, R N, Lunetta, K L, Lynch, S N, Markus, M R, Marques-Vidal, P, Mateo Leach, I, McArdle, W L, McCarroll, S A, Medland, S E, Miller, K A, Montgomery, G W, Morrison, A C, Müller-Nurasyid, M, Navarro, P, Nelis, M, O'Connell, J R, O'Donnell, C J, Ong, K K, Newman, A B, Peters, A, Polasek, O, Pouta, A, Pramstaller, P P, Psaty, B M, Rao, D C, Ring, S M, Rossin, E J, Rudan, D, Sanna, S, Scott, R A, Sehmi, J S, Sharp, S, Shin, J T, Singleton, A B, Smith, A V, Soranzo, N, Spector, T D, Stewart, C, Stringham, H M, Tarasov, K V, Uitterlinden, A G, Vandenput, L, Hwang, S J, Whitfield, J B, Wijmenga, C, Wild, S H, Willemsen, G, Wilson, J F, Witteman, J C, Wong, A, Wong, Q, Jamshidi, Y, Zitting, P, Boer, J M, Boomsma, D I, Borecki, I B, van Duijn, C M, Ekelund, U, Forouhi, N G, Froguel, P, Hingorani, A D, Ingelsson, E, Kivimaki, M, Kronmal, R A, Kuh, D, Lind, L, Martin, N G, Oostra, B A, Pedersen, N L, Quertermous, T, Rotter, J I, van der Schouw, Y T, Verschuren, W M, Walker, M, Albanes, D, Arnar, D O, Assimes, T L, Bandinelli, S, Boehnke, M, de Boer, R A, Bouchard, C, Caulfield, W L, Chambers, J C, Curhan, G, Cusi, D, Eriksson, J, Ferrucci, L, van Gilst, W H, Glorioso, N, de Graaf, J, Groop, L, Gyllensten, U, Hsueh, W C, Hu, F B, Huikuri, H V, Hunter, D J, Iribarren, C, Isomaa, B, Järvelin, M R, Jula, A, Kähönen, M, Kiemeney, L A, van der Klauw, M M, Kooner, J S, Kraft, P, Iacoviello, L, Lehtimäki, T, Lokki, M L, Mitchell, B D, Navis, G, Nieminen, M S, Ohlsson, C, Poulter, N R, Qi, L, Raitakari, O T, Rimm, E B, Rioux, J D, Rizzi, F, Rudan, I, Salomaa, V, Sever, P S, Shields, D C, Shuldiner, A R, Sinisalo, J, Stanton, A V, Stolk, R P, Strachan, D P, Tardif, J C, Thorsteinsdottir, U, Tuomilehto, J, van Veldhuisen, D J, Virtamo, J, Viikari, J, Vollenweider, P, Waeber, G, Widen, E, Cho, Y S, Olsen, J V, Visscher, P M, Willer, C J, Franke, L, Erdmann, J, Thompson, J R, Pfeufer, A, Sotoodehnia, N, Newton-Cheh, C, Ellinor, P T, Stricker, B H C, Metspalu, A, Perola, M, Beckmann, J S, Smith, G D, Stefansson, K, Wareham, N J, Munroe, P B, Sibon, O C M, Milan, D J, Snieder, H, Samani, N J & Loos, R J 2013, ' Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders ', Nature Genetics, vol. 45, no. 6, pp. 621-631 . https://doi.org/10.1038/ng.2610
Nature Genetics

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f091499ff4331cd37912032e3ea160
https://acuresearchbank.acu.edu.au/item/85846/identification-of-heart-rate-associated-loci-and-their-effects-on-cardiac-conduction-and-rhythm-disorders

4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.

Autor: Jeong SY; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Hogarth P; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.; Department of Neurology, Oregon Health & Science University, Portland, OR, USA., Placzek A; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, USA., Gregory AM; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Fox R; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Zhen D; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Hamada J; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., van der Zwaag M; Department of Cell Biology, University Medical Center Groningen, Groningen, the Netherlands., Lambrechts R; Department of Cell Biology, University Medical Center Groningen, Groningen, the Netherlands., Jin H; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, USA., Nilsen A; Medicinal Chemistry Core, Oregon Health & Science University, Portland, OR, USA., Cobb J; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Pham T; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Gray N; Department of Neurology, Oregon Health & Science University, Portland, OR, USA., Ralle M; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Duffy M; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Schwanemann L; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Rai P; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Freed A; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Wakeman K; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Woltjer RL; Department of Pathology, Oregon Health & Science University, Portland, OR, USA., Sibon OC; Department of Cell Biology, University Medical Center Groningen, Groningen, the Netherlands., Hayflick SJ; Department of Molecular & Medical Genetics, Oregon Health & Science University, Portland, OR, USA.; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.; Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2019 Dec; Vol. 11 (12), pp. e10489. Date of Electronic Publication: 2019 Oct 29.

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.

Autor: Vonk JJ; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Yeshaw WM; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Pinto F; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Faber AI; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Lahaye LL; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kanon B; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van der Zwaag M; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Velayos-Baeza A; Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom., Freire R; Unidad de Investigación, Hospital Universitario de Canarias, Instituto de Tecnologías Biomédicas, Ofra s/n, La Laguna, Tenerife, Spain., van IJzendoorn SC; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Grzeschik NA; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Sibon OC; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: PloS one [PLoS One] 2017 Jan 20; Vol. 12 (1), pp. e0170106. Date of Electronic Publication: 2017 Jan 20 (Print Publication: 2017).

Specific protein homeostatic functions of small heat-shock proteins increase lifespan.

Autor: Vos MJ; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Carra S; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Kanon B; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bosveld F; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Klauke K; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Sibon OC; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Kampinga HH; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: Aging cell [Aging Cell] 2016 Apr; Vol. 15 (2), pp. 217-26. Date of Electronic Publication: 2015 Dec 25.

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis.

Autor: Srinivasan B; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Baratashvili M; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., van der Zwaag M; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kanon B; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Colombelli C; Unit of Molecular Neurogenetics, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy., Lambrechts RA; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Schaap O; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Nollen EA; European Research Institute for the Biology of Aging, University of Groningen, Groningen, the Netherlands., Podgoršek A; Acies Bio d.o.o., Ljubljana, Slovenia., Kosec G; Acies Bio d.o.o., Ljubljana, Slovenia., Petković H; Acies Bio d.o.o., Ljubljana, Slovenia., Hayflick S; Departments of Molecular and Medical Genetics, Pediatrics, and Neurology, Oregon Health &Science University, Portland, Oregon, USA., Tiranti V; Unit of Molecular Neurogenetics, Foundation IRCCS Neurological Institute C. Besta, Milan, Italy., Reijngoud DJ; Department of Laboratory Medicine, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, Groningen, the Netherlands.., Grzeschik NA; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Sibon OC; Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2015 Oct; Vol. 11 (10), pp. 784-92. Date of Electronic Publication: 2015 Aug 31.