Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sibah Hasan"'
Autor:
Sanskar Ranglani, Sibah Hasan, Kashif Mahfooz, Jack Gordon, Sara Garcia-Rates, Susan Greenfield
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115498- (2023)
T14, a 14mer peptide derived from the C-terminus of acetylcholinesterase (AChE) is a signalling molecule that could drive neurodegeneration via the alpha 7 nicotinic acetylcholine receptor. Its levels increase as Alzheimer’s pathology progresses; h
Externí odkaz:
https://doaj.org/article/b4d8de3c9a6c475ba3900e4df4e98f2a
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114120- (2023)
A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration. Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target alpha-7 receptor by a cyclised variant, ‘NBP14′, which has beneficial ef
Externí odkaz:
https://doaj.org/article/d469175d583f425f9cf710d32076c817
Autor:
Susan A. Greenfield, Gregory M. Cole, Clive W. Coen, Sally Frautschy, Ram P. Singh, Marisa Mekkittikul, Sara Garcia‐Ratés, Paul Morrill, Owen Hollings, Matt Passmore, Sibah Hasan, Nikisha Carty, Silvia Bison, Laura Piccoli, Renzo Carletti, Stephano Tacconi, Anna Chalidou, Matthew Pedercini, Tim Kroecher, Hubert Astner, Philip A. Gerrard
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The neuronal mechanism driving Alzheimer's disease (AD) is incompletely understood. Methods Immunohistochemistry, pharmacology, biochemistry, and behavioral testing are employed in two pathological contexts—AD and a transgenic
Externí odkaz:
https://doaj.org/article/07684a389acc417a9545fbf1b57c644f
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Circadian rhythms and sleep-wake history determine sleep duration and intensity, and influence subsequent waking. Previous studies have shown that T cycles - light-dark (LD) cycles differing from 24 h - lead to acute changes in the daily amo
Externí odkaz:
https://doaj.org/article/1b3178f8f0a94faa85a910285df92d3d
Publikováno v:
Wellcome Open Research, Vol 1 (2017)
Background: Disruption of rhythms in activity and rest occur in many diseases, and provide an important indicator of healthy physiology and behaviour. However, outside the field of sleep and circadian rhythm research, these rhythmic processes are rar
Externí odkaz:
https://doaj.org/article/dd9b0349fad040008ee0e7f290da4558
Autor:
David Pritchett, Aarti Jagannath, Laurence A Brown, Shu K E Tam, Sibah Hasan, Silvia Gatti, Paul J Harrison, David M Bannerman, Russell G Foster, Stuart N Peirson
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125523 (2015)
Sleep and/or circadian rhythm disruption (SCRD) is seen in up to 80% of schizophrenia patients. The co-morbidity of schizophrenia and SCRD may in part stem from dysfunction in common brain mechanisms, which include the glutamate system, and in partic
Externí odkaz:
https://doaj.org/article/c4b58918dccf4eff9c8d7e496512573c
Autor:
June C Lo, John A Groeger, Nayantara Santhi, Emma L Arbon, Alpar S Lazar, Sibah Hasan, Malcolm von Schantz, Simon N Archer, Derk-Jan Dijk
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45987 (2012)
BackgroundCognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive pr
Externí odkaz:
https://doaj.org/article/f9a2a2d2ddbd4ea68a2312b687329a65
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 158
A 14mer peptide, T14, is a possible signaling molecule driving neurodegeneration. Its levels are doubled in the Alzheimer brain, but its effects can be blocked at the target alpha-7 receptor by a cyclised variant, 'NBP14', which has beneficial effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955085086f5e481e37bb91da8b991a6b
https://pubmed.ncbi.nlm.nih.gov/36521245
https://pubmed.ncbi.nlm.nih.gov/36521245
Autor:
Sridhar R. Vasudevan, Mohammed S, Lewis Taylor, Clark K, Teele Palumaa, Stuart N. Peirson, Paul K. Reardon, Liberatori S, Steven Walsh, Johnson B, Philip Cohen, Russell G. Foster, Vladyslav V. Vyazovskiy, Sibah Hasan, Aarti Jagannath
SUMMARYThe sleep and circadian systems act in concert to regulate sleep-wake timing, yet the molecular mechanisms that underpin their interaction to induce sleep remain unknown. Synaptic protein phosphorylation, driven by the kinase SIK3, correlates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd2276c4b6e0876f2b021d46e20300c
https://doi.org/10.1101/2021.09.28.462159
https://doi.org/10.1101/2021.09.28.462159
Autor:
Russell G. Foster, Tam Ske., Sibah Hasan, Vladyslav V. Vyazovskiy, Stuart N. Peirson, David M. Bannerman
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Acute exposure to light exerts widespread effects on physiology, in addition to its key role in photoentrainment. Although the modulatory effect of light on physiological arousal is well demonstrated in mice, its effect on mem
Acute exposure to light exerts widespread effects on physiology, in addition to its key role in photoentrainment. Although the modulatory effect of light on physiological arousal is well demonstrated in mice, its effect on mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc8efbb1c99f92153d9b814f56c0e3b
http://europepmc.org/articles/PMC8363935
http://europepmc.org/articles/PMC8363935