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pro vyhledávání: '"Siaw Wei Ng"'
Communication between the cell surface and the nucleus is essential for regulated gene expression. In neurons, Ca(2+)-dependent gene transcription is sensitive to local Ca(2+) entry. In immune cells, excitation-transcription coupling is thought to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d2cf2ffa90cf4c976ee266be7777b6
https://doi.org/10.1074/jbc.m109.011692
https://doi.org/10.1074/jbc.m109.011692
Autor:
Robert Almeyda, Charmaine Nelson, Daniel Bakowski, Anant B. Parekh, Ravi Mehta, Siaw-Wei Ng, Grant Bates
Publikováno v:
Nature
Receptor desensitization is a universal mechanism to turn off a biological response; in this process, the ability of a physiological trigger to activate a cell is lost despite the continued presence of the stimulus. Receptor desensitization of G-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45406291b05eb69f03463ee3d50d2ad1
https://doi.org/10.1038/nature10731
https://doi.org/10.1038/nature10731
Publikováno v:
International Immunopharmacology. 8:810-818
Sepsis is a complex clinical syndrome resulting from a harmful host inflammatory response to infection. Similarly, lipopolysaccharide (LPS) induced endotoxemia is marked by the activation of inflammatory responses, which can lead to shock, multiple o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7412c6af9baac89a423a0d08fef5dce0
https://doi.org/10.1016/j.intimp.2008.01.033
https://doi.org/10.1016/j.intimp.2008.01.033
Publikováno v:
Journal of Leukocyte Biology. 83:288-295
Endotoxemia is a life-threatening, inflammatory condition that involves multiple organ injury and dysfunction. Preprotachykinin-A (PPT-A) gene products, substance P (SP), and neurokinin-A have been shown to play an important role in neurogenic inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fadafee344a1173048f3d38a5ce5a49
https://doi.org/10.1189/jlb.0807575
https://doi.org/10.1189/jlb.0807575
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis
Publikováno v:
Journal of Cellular and Molecular Medicine
Hydrogen sulphide (H(2)S), a novel gasotransmitter, has been recognized to play an important role in inflammation. Cystathionine-gamma-lyase (CSE) is a major H(2)S synthesizing enzyme in the cardiovascular system and DL-propargylglycine (PAG) is an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc0e0e28862cec8413f6cf88187833b
http://europepmc.org/articles/PMC3822545
http://europepmc.org/articles/PMC3822545
Publikováno v:
The Journal of Immunology. 179:4153-4160
Hydrogen sulfide (H2S) has been shown to induce the activation of neurogenic inflammation especially in normal airways and urinary bladder. However, whether endogenous H2S would regulate sepsis-associated lung inflammation via substance P (SP) and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea312a9bd3deff22b0dc9374eff62331
https://doi.org/10.4049/jimmunol.179.6.4153
https://doi.org/10.4049/jimmunol.179.6.4153
Autor:
Akhil Hegde, Hon Yen Lau, Madhav Bhatia, Jia Lu, Siaw Wei Ng, Shabbir Moochhala, Padmam Puneet
Publikováno v:
The Journal of Immunology. 176:3813-3820
Preprotachykinin-A (PPT-A) gene products substance P and neurokinin-A have been shown to play an important role in neurogenic inflammation. To investigate the role of PPT-A gene products in lung injury in sepsis, polymicrobial sepsis was induced by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42784a74e7b0118e54b94248c4f055
https://doi.org/10.4049/jimmunol.176.6.3813
https://doi.org/10.4049/jimmunol.176.6.3813
Autor:
Luca Scorrano, Olga Martins de Brito, Joseph Di Capite, Anant B. Parekh, Trevor Powell, Charmaine Nelson, Karthika Singaravelu, Siaw-Wei Ng, Daniel Bakowski
Publikováno v:
The Journal of biological chemistry
Store-operated Ca2+ channels in the plasma membrane (PM) are activated by the depletion of Ca2+ from the endoplasmic reticulum (ER) and constitute a widespread and highly conserved Ca2+ influx pathway. After store emptying, the ER Ca2+ sensor STIM1 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed7df26342b7b5d5aa06b60323948e5
http://ora.ox.ac.uk/objects/uuid:9b06d0c3-3da0-4eeb-88be-642106b16af7
http://ora.ox.ac.uk/objects/uuid:9b06d0c3-3da0-4eeb-88be-642106b16af7
Autor:
Siaw-Wei Ng
Inappropriate stimulation of mast cells can trigger allergies including asthma, allergic rhinitis and eczema which, combined, affect almost 30% of the population in western societies. Mast cell activation begins with aggregation of IgE receptors in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::601f7e56cd1c81e701db4c9d570bf2a9
http://ora.ox.ac.uk/objects/uuid:b3843e43-9503-4855-a280-35c0d28f65e6
http://ora.ox.ac.uk/objects/uuid:b3843e43-9503-4855-a280-35c0d28f65e6
Publikováno v:
Journal of Inflammation (London, England)
Journal of Inflammation, Vol 6, Iss 1, p 35 (2009)
Journal of Inflammation, Vol 6, Iss 1, p 35 (2009)
Background Hydrogen sulfide (H2S), a gaseous mediator plays an important role in a wide range of physiological and pathological processes. H2S has been extensively studied for its various roles in cardiovascular and neurological disorders. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80cdc32b7d1d44743c6e9c19d4ca855
https://pubmed.ncbi.nlm.nih.gov/20040116
https://pubmed.ncbi.nlm.nih.gov/20040116