Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Siang-Yo Lin"'
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Matriptase is a transmembrane serine protease, synthesized as an inactive single-chain zymogen on the endoplasmic reticulum and transported to the plasma membrane. Matriptase is activated in different epithelial and some B-cell malignancies and chang
Externí odkaz:
https://doaj.org/article/ed9517bd3eb145bc8156d8ec322620cc
Autor:
Siang-Yo Lin, Mehdi Javanmard, Chen-Yong Lin, Joseph R. Bertino, Zhongtian Lin, Gulam M. Rather, Pengfei Xie
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The rapid qualitative assessment of surface markers on cancer cells can allow for point-of-care prediction of patient response to various cancer drugs. Preclinical studies targeting cells with an antibody to “activated” matriptase conjugated to a
Autor:
Michael D. Johnson, Gulam M. Rather, Chen-Yong Lin, Hongxia Lin, Siang-Yo Lin, Kim M. Hirshfield, Whitney Banach-Petrosky, Zoltan Szekely, Joseph R. Bertino
Publikováno v:
Oncotarget
The antitumor effects of a novel antibody drug conjugate (ADC) was tested against human solid tumor cell lines and against human triple negative breast cancer (TNBC) xenografts in immunosuppressed mice. The ADC targeting activated matriptase of tumor
Autor:
John Glod, Jaidong Li, Kuo-Chieh Lee, Siang-Yo Lin, Debabrata Banerjee, Christopher DeRenzo, Sohrab Amiri, Sonia C. Dolfi, Tulin Budak-Alpdogan
Publikováno v:
International Journal of Oncology
Mesenchymal stromal cells (MSCs) are multipotent fibroblast-like cells located in the bone marrow that localize to areas of tissue damage including wounds and solid tumors. Within the tumor microenvironment, MSCs adopt the phenotype of carcinoma-asso
Autor:
John Glod, Mythili Koneru, Jun Yang, Allen D. Everett, Barton Kamen, Siang Yo Lin, Pravin J. Mishra, Charles V. Clevenger, Debabrata Banerjee
Publikováno v:
Experimental Cell Research. 314:3107-3117
Bone marrow-derived mesenchymal stromal cells (MSCs) localize to solid tumors. Defining the signaling mechanisms that regulate this process is important in understanding the role of MSCs in tumor growth. Using a combination of chromatography and elec
Autor:
Hui Gao, Sonia C. Picinich, Rajeth Koneru, Siang Yo Lin, Mythili Koneru, Lata G. Menon, John Glod, Philipp Mayer-Kuckuk, Debabrata Banerjee
Publikováno v:
Stem Cells. 25:520-528
Distinct signals that guide migration of mesenchymal stem cells (MSCs) to specific in vivo targets remain unknown. We have used rat MSCs to investigate the molecular mechanisms involved in such migration. Rat MSCs were shown to migrate to tumor micro
Publikováno v:
Journal of Biological Chemistry. 281:1746-1754
The focal adhesion kinase (FAK) is a key regulator of cell migration. Phosphorylation at Tyr-397 activates FAK and creates a binding site for Src family kinases. FAK phosphorylates the cytoskeletal protein alpha-actinin at Tyr-12. Here we report that
Publikováno v:
Cancer Research. 77:4615-4615
Treatment for patients with advanced solid tumors that include triple negative breast cancer (TNBC), non-small cell lung cancer (NSCLC), and castrate resistant prostate cancer (CRPC), as well as Mantle Cell Lymphoma (MCL), while increasing survival i
Publikováno v:
Journal of Neuroscience Research. 59:454-463
Although neurotrophins are critical for neuronal survival and differentiation, recent studies suggest that they also regulate synaptic plasticity. Brain-derived neurotrophic factor (BDNF) rapidly increases synaptic transmission in hippocampal neurons
Publikováno v:
Molecular Brain Research. 59:215-228
N -methyl- d -aspartate (NMDA) receptors (NRs) play critical roles in diverse synaptic processes in the brain. However, subcellular distribution, spatiotemporal expression and regulation of NR subunits in brain synapses are unknown. We report that NR