Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Siang Boon, Koh"'
Autor:
Yumin Wang, Boya Gao, Luyuan Zhang, Xudong Wang, Xiaolan Zhu, Haibo Yang, Fengqi Zhang, Xueping Zhu, Badi Zhou, Sean Yao, Aiko Nagayama, Sanghoon Lee, Jian Ouyang, Siang-Boon Koh, Eric L. Eisenhauer, Dominique Zarrella, Kate Lu, Bo R. Rueda, Lee Zou, Xiaofeng A. Su, Oladapo Yeku, Leif W. Ellisen, Xiao-Song Wang, Li Lan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonemal complex, is aberrantly and com
Externí odkaz:
https://doaj.org/article/fee47f6ec5bd4fda828f917b06a525d3
Autor:
Yumin Wang, Boya Gao, Luyuan Zhang, Xudong Wang, Xiaolan Zhu, Haibo Yang, Fengqi Zhang, Xueping Zhu, Badi Zhou, Sean Yao, Aiko Nagayama, Sanghoon Lee, Jian Ouyang, Siang-Boon Koh, Eric L. Eisenhauer, Dominique Zarrella, Kate Lu, Bo R. Rueda, Lee Zou, Xiaofeng A. Su, Oladapo Yeku, Leif W. Ellisen, Xiao-Song Wang, Li Lan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e5d9d1b5c22f4da1876d5d6a6b5140cd
Autor:
Siang-Boon Koh, Brian N. Dontchos, Veerle Bossuyt, Christine Edmonds, Simona Cristea, Nsan Melkonjan, Lindsey Mortensen, Annie Ma, Kassidy Beyerlin, Elyssa Denault, Elizabeth Niehoff, Taghreed Hirz, David B. Sykes, Franziska Michor, Michelle Specht, Constance Lehman, Leif W. Ellisen, Laura M. Spring
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-7 (2021)
Abstract Systematic collection of fresh tissues for research at the time of diagnostic image-guided breast biopsy has the potential to fuel a wide variety of innovative studies. Here we report the initial experience, including safety, feasibility, an
Externí odkaz:
https://doaj.org/article/bb4e9fd066134280a9174b2fe59dc262
Autor:
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L. Bramhall, Tai-Ping Fan, Andreas Bender
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103080- (2021)
Summary: Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on trans
Externí odkaz:
https://doaj.org/article/69cd70dbe9ff4fdb8050f751b9552302
Autor:
Syed IA Bukhari, Samuel S Truesdell, Chandreyee Datta, Pritha Choudhury, Keith Q Wu, Jitendra Shrestha, Ruby Maharjan, Ethan Plotsker, Ramzi Elased, Sadia Laisa, Vijeta Bhambhani, Yue Lin, Johannes Kreuzer, Robert Morris, Siang-Boon Koh, Leif W. Ellisen, Wilhelm Haas, Amy Ly, Shobha Vasudevan
Publikováno v:
bioRxiv
Our data previously revealed that chemosurviving cancer cells translate specific genes. Here, we find that the m6A-RNA-methyltransferase, METTL3, increases transiently in chemotherapy-treated breast cancer and leukemic cells in vitro and in vivo. Con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c648e406c889874ee2a350109453e95
https://doi.org/10.1101/2023.05.19.540602
https://doi.org/10.1101/2023.05.19.540602
Autor:
Duncan I. Jodrell, Frances M. Richards, Alan Lau, Sandra Bernaldo de Quirós Fernández, James W.T. Yates, Chiara Fornari, Siang-Boon Koh, Timothy Isaac Johnson, Charles R. Dunlop, Yann Wallez
AZD6738 and gemcitabine synergistically inhibit cell growth in a panel of PDAC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48842dba68fded585e597a16be131cc3
https://doi.org/10.1158/1535-7163.22504494
https://doi.org/10.1158/1535-7163.22504494
Autor:
Duncan I. Jodrell, Frances M. Richards, Alan Lau, Sandra Bernaldo de Quirós Fernández, James W.T. Yates, Chiara Fornari, Siang-Boon Koh, Timothy Isaac Johnson, Charles R. Dunlop, Yann Wallez
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest cancers, and overall survival rates have barely improved over the past five decades. The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a674a747e8fbe7b3589a446453eeda2e
https://doi.org/10.1158/1535-7163.c.6537753.v1
https://doi.org/10.1158/1535-7163.c.6537753.v1
Autor:
Duncan I. Jodrell, Frances M. Richards, Alan Lau, Sandra Bernaldo de Quirós Fernández, James W.T. Yates, Chiara Fornari, Siang-Boon Koh, Timothy Isaac Johnson, Charles R. Dunlop, Yann Wallez
Genetic alterations likely to sensitize to ATR inhibition in the human PDAC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae5ee54dffa886a110e637a547155f5
https://doi.org/10.1158/1535-7163.22504491
https://doi.org/10.1158/1535-7163.22504491
Autor:
Duncan I. Jodrell, Frances M. Richards, Robert G. Boyle, Richard J. Boyce, Aurélie Courtin, Siang-Boon Koh
Supplementary Figures S1-S5. Effective synergy at sub-GI50 concentrations (S1); Mitotic entry at synergistic concentrations (S2); Cell fate upon gemcitabine and CHK1 inhibition (S3); Replication stress upon gemcitabine and CHK1 inhibition (S4); Mitot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48443d2eafcab697f76aac425f9e16dc
https://doi.org/10.1158/0008-5472.22405116
https://doi.org/10.1158/0008-5472.22405116
Autor:
Duncan I. Jodrell, Frances M. Richards, Robert G. Boyle, Richard J. Boyce, Aurélie Courtin, Siang-Boon Koh
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106be3d527ae8826b16dcb9a6f746d18
https://doi.org/10.1158/0008-5472.22405113
https://doi.org/10.1158/0008-5472.22405113