Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sian Stafford"'
Autor:
Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rul
Externí odkaz:
https://doaj.org/article/f49351239a2f427ab2056944955526c8
Autor:
Marina Ollé Hurtado, Jolien Wolbert, Jonathan Fisher, Barry Flutter, Sian Stafford, Jack Barton, Neha Jain, Giuseppe Barone, Yvonne Majani, John Anderson
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0216373 (2019)
Adoptive transfer of ex vivo expanded tumor infiltrating lymphocytes (TILs) has led to clinical benefit in some patients with melanoma but has not demonstrated convincing efficacy in other solid cancers. Whilst the presence of TILs in many types of c
Externí odkaz:
https://doaj.org/article/5012a66a934441b586f58958e850d7f1
Autor:
Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Roslyn A. Hendriks, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/d740ed64c3ac49a68c827986110142dc
Autor:
Lorenzo Biassoni, Julie Silvester, Jack Barton, Claire Barton, Muhammad Al-Hajj, Clare Marriott, Talia Gileadi, Thalia Loka, John Anderson, Simon Thomas, Karin Straathof, Stephanie Traub, Sarah Inglott, Lesley Robson, Evangelia Kokalaki, Giuseppe Barone, Kieran McHugh, Lily Elson, Karen Dyer, Karen Howe, Sarita Depani, Teresa Marafioti, Ami Bedi, Natalie Sizer, Sian Stafford, Nigel Westwood, Olumide Ogunbiyi, Gordon Weng-Kit Cheung, Barry Flutter, Sue Brook, Martin Pule, Dyanne Rampling, Gary Wright, Kimberly Gilmour, Rebecca Wallace, Catriona Duncan, David P. Edwards, Ailish Barry, William Day, Neha Jain, Ilaria Dragoni, Ayse U. Akarca
Publikováno v:
Science Translational Medicine. 12
The reprogramming of a patient’s immune system through genetic modification of the T cell compartment with chimeric antigen receptors (CARs) has led to durable remissions in chemotherapy-refractory B cell cancers. Targeting of solid cancers by CAR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32b9df16f52d81da80ca0f47c5a9801
https://doi.org/10.1126/scitranslmed.abd6169
https://doi.org/10.1126/scitranslmed.abd6169
Autor:
Krupa Arun Navalkar, Brian A. Fox, Leo McHugh, Cristina Venturini, Antony Rapisarda, Thomas D. Yager, Eliza Gil, Evi Tsaliki, Roslyn A. Hendriks, Sian Stafford, Benjamin M. Chain, Mahdad Noursadeghi, Dayle Sampson, Laura Shallcross, Nandi Simpson, Jennifer K. Roe, Richard Bruce Brandon, Therese Seldon
Publikováno v:
BMC Medicine
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rule-out blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d0a54ebe429c461d3f68c506cb456e
https://doi.org/10.1186/s12916-020-01653-3
https://doi.org/10.1186/s12916-020-01653-3
Autor:
Barry Flutter, Jonathan Fisher, Yvonne Majani, Jack Barton, John Anderson, Sian Stafford, Jolien Wolbert, Marina Ollé Hurtado, Giuseppe Barone, Neha Jain
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0216373 (2019)
PLoS ONE, Vol 14, Iss 8, p e0216373 (2019)
Adoptive transfer of ex vivo expanded tumor infiltrating lymphocytes (TILs) has led to clinical benefit in some patients with melanoma but has not demonstrated convincing efficacy in other solid cancers. Whilst the presence of TILs in many types of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bca6b39709c400581f6dd3a95e025b8
http://europepmc.org/articles/PMC6688820
http://europepmc.org/articles/PMC6688820
Autor:
Waseem Qasim, Sian Stafford, Danielle Pinner, Karl S. Peggs, Sujith Samarasinghe, Giovanna Lucchini, Sarah Inglott, Christine Rivat, Robert Chiesa, Persis Amrolia, Martin Pule, Adrian J. Thrasher, Kimberly Gilmour, Ajay Vora, Hong Zhan, Paul Veys, William Mifsud, Farzin Farzeneh, Sara Ghorashian, Kathy Somana, Stuart Adams, Gul Ahsan, Gary Wright, Lucas Chan, Katie Butler
Publikováno v:
Science Translational Medicine. 9
Autologous T cells engineered to express chimeric antigen receptor against the B cell antigen CD19 (CAR19) are achieving marked leukemic remissions in early-phase trials but can be difficult to manufacture, especially in infants or heavily treated pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1be39960a1be9a48fbbc69f0b0c2c0
https://doi.org/10.1126/scitranslmed.aaj2013
https://doi.org/10.1126/scitranslmed.aaj2013
Autor:
Jeremy S. Brown, Waldemar Vollmer, Gillian S. Tomlinson, Sian Stafford, Mahdad Noursadeghi, Emilie Camberlein, Capucine Picard, Jimstan Periselneris, Thabo Lapp, Tracey Pollard, Jean-Laurent Casanova, Suneeta Chimalapati, Christine Aldridge, Jonathan M. Cohen
Publikováno v:
The Journal of Immunology Author Choice
Streptococcus pneumoniae infections induce inflammatory responses that contribute toward both disease pathogenesis and immunity, but the host–pathogen interactions that mediate these effects are poorly defined. We used the surface lipoprotein-defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59b7c781eab58752b9f73f7fe9944d9
https://doi.org/10.4049/jimmunol.1401413
https://doi.org/10.4049/jimmunol.1401413
Autor:
Jennifer K, Roe, Niclas, Thomas, Eliza, Gil, Katharine, Best, Evdokia, Tsaliki, Stephen, Morris-Jones, Sian, Stafford, Nandi, Simpson, Karolina D, Witt, Benjamin, Chain, Robert F, Miller, Adrian, Martineau, Mahdad, Noursadeghi
Publikováno v:
JCI Insight
BACKGROUND. Novel rapid diagnostics for active tuberculosis (TB) are required to overcome the time delays and inadequate sensitivity of current microbiological tests that are critically dependent on sampling the site of disease. Multiparametric blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::431ab2f18b6c9cc7a9b6076c9a45ddc6
https://pubmed.ncbi.nlm.nih.gov/27734027
https://pubmed.ncbi.nlm.nih.gov/27734027
Autor:
Sue Swift, Robert Chiesa, Nicholas Goulden, Steve Chatters, Martin Pule, Persis Amrolia, Stuart Adams, Karl S. Peggs, Kimberly Gilmour, Hong Zhan, Paul Veys, Sian Stafford, Danielle Pinner, Sara Ghorashian, Sujith Samarasinghe, Waseem Qasim, Adrian J. Thrasher, Gul Ahsan, Katie Butler
Publikováno v:
Blood. 126:2046-2046
Chimeric antigen receptor (CAR)19 T-cells exhibit powerful anti-leukemic effects in patients with B cell malignancies. However, the complexity of production of patient bespoke T cell products is a major barrier to the broader application of this appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e03c403aafe9310bd970190e13dfbd
https://doi.org/10.1182/blood.v126.23.2046.2046
https://doi.org/10.1182/blood.v126.23.2046.2046