Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

Autor: Mattia Privitera, Lukas M von Ziegler, Amalia Floriou-Servou, Sian N Duss, Runzhong Zhang, Rebecca Waag, Sebastian Leimbacher, Oliver Sturman, Fabienne K Roessler, Annelies Heylen, Yannick Vermeiren, Debby Van Dam, Peter P De Deyn, Pierre-Luc Germain, Johannes Bohacek

Publikováno v: eLife, Vol 12 (2024)

Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains a major challenge. Here, we combine RNA sequencing with selective

Externí odkaz: https://doaj.org/article/e31eb3ec28a24c24ac3e22f507e84dfa

Locus Coeruleus firing patterns selectively modulate brain activity and dynamics

Autor: Christina Grimm, Sian N. Duss, Mattia Privitera, Brandon R. Munn, Stefan Frässle, Maria Chernysheva, Tommaso Patriarchi, Daniel Razansky, Nicole Wenderoth, James M. Shine, Johannes Bohacek, Valerio Zerbi

Noradrenaline (NA) release from the brainstem nucleus locus coeruleus (LC) changes activity and connectivity in neuronal networks across the brain, thus modulating multiple behavioural states. NA release is mediated by both tonic and burst-like neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1940d40e284cd77e0e47ce406eee0a7
https://doi.org/10.1101/2022.08.29.505672

Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice

Autor: Peter Paul De Deyn, Johannes Bohacek, Letizia Giovagnoli, Mattia Privitera, Oliver Sturman, Yannick Vermeiren, Sian N Duss, Rebecca Waag, Lukas von Ziegler

Publikováno v: Neurobiology of Stress
Neurobiology of stress, 15:100388. ELSEVIER SCIENCE INC
Neurobiology of Stress 15 (2021)
Neurobiology of Stress, Vol 15, Iss, Pp 100388-(2021)
Neurobiology of Stress, 15

Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness later in life and is associated with increased mental health issues in adulthood. Here we investigate whether the Chronic Social Instability (CSI) paradigm i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22997ec8c96a4c0ebb875a37404ef5e
https://hdl.handle.net/11370/d7ed23d4-a433-4d66-a761-d4afa7efac1e

Multiomic profiling of the acute stress response in the mouse hippocampus

Autor: Lukas M, von Ziegler, Amalia, Floriou-Servou, Rebecca, Waag, Rebecca R, Das Gupta, Oliver, Sturman, Katharina, Gapp, Christina A, Maat, Tobias, Kockmann, Han-Yu, Lin, Sian N, Duss, Mattia, Privitera, Laura, Hinte, Ferdinand, von Meyenn, Hanns U, Zeilhofer, Pierre-Luc, Germain, Johannes, Bohacek

Publikováno v: Nature communications. 13(1)

The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief swim exposure to trigger an acute stress response in mice, which transie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37fc2c25496de80d827f094bb2842d23
https://pubmed.ncbi.nlm.nih.gov/35383160

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

Autor: Mattia, Privitera, Kim David, Ferrari, Lukas M, von Ziegler, Oliver, Sturman, Sian N, Duss, Amalia, Floriou-Servou, Pierre-Luc, Germain, Yannick, Vermeiren, Matthias T, Wyss, Peter P, De Deyn, Bruno, Weber, Johannes, Bohacek

Publikováno v: Nature protocols. 15(8)

The locus coeruleus (LC) is a region in the brainstem that produces noradrenaline and is involved in both normal and pathological brain function. Pupillometry, the measurement of pupil diameter, provides a powerful readout of LC activity in rodents,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::117c8ea0016cb6a6edb7690cdcb4b189
https://pubmed.ncbi.nlm.nih.gov/33446938