Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Sian E, Harding"'
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/8d9708597f2d4c6a9de9eee8cb27059a
Autor:
Tünde Berecz, Angela Yiu, Orsolya Vittay, Barbara Orsolits, Maxime Mioulane, Cristobal G. dosRemedios, Robin Ketteler, Bela Merkely, Ágota Apáti, Sian E. Harding, Nicola Hellen, Gabor Foldes
Publikováno v:
ESC Heart Failure, Vol 9, Iss 1, Pp 224-235 (2022)
Abstract Aims Hippo signalling is an evolutionarily conserved pathway that controls organ size by regulating apoptosis, cell proliferation, and stem cell self‐renewal. Recently, the pathway has been shown to exert powerful growth regulatory activit
Externí odkaz:
https://doaj.org/article/cfa42de32b8a4c7f89de595f9ce54f50
Autor:
Matthew H. Tranter, Bjorn Redfors, Peter T. Wright, Liam S. Couch, Alexander R. Lyon, Elmir Omerovic, Sian E. Harding
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Externí odkaz:
https://doaj.org/article/f139f885c3064701be96a3352242678a
Autor:
Matthew H. Tranter, Bjorn Redfors, Peter T. Wright, Liam S. Couch, Alexander R. Lyon, Elmir Omerovic, Sian E. Harding
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Takotsubo syndrome is a well-characterized cause of acute yet reversible heart failure associated with periods of intense emotional stress, often mimicking on presentation an acute coronary syndrome. Animal models of Takotsubo syndrome have been deve
Externí odkaz:
https://doaj.org/article/832d9a42e1024e01ac9512c49e2013e4
Autor:
Alexander Kondrashov, Nurul A.N. Mohd Yusof, Alveera Hasan, Joëlle Goulding, Thusharika Kodagoda, Duc M. Hoang, Nguyen T.N. Vo, Tony Melarangi, Nazanin Dolatshad, Julia Gorelik, Stephen J. Hill, Sian E. Harding, Chris Denning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 39-53 (2021)
During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studi
Externí odkaz:
https://doaj.org/article/63fcae800ab4494e927ca2eba3c4b859
Autor:
Damiano Fassina, Caroline M Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E Harding, Steven A Niederer
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010030 (2022)
Application of epicardial patches constructed from human-induced pluripotent stem cell- derived cardiomyocytes (hiPSC-CMs) has been proposed as a long-term therapy to treat scarred hearts post myocardial infarction (MI). Understanding electrical inte
Externí odkaz:
https://doaj.org/article/5fbdad1b48774d249685a288a0322e37
Autor:
Richard J. Jabbour, Thomas J. Owen, Pragati Pandey, Marina Reinsch, Brian Wang, Oisín King, Liam Steven Couch, Dafni Pantou, David S. Pitcher, Rasheda A. Chowdhury, Fotios G. Pitoulis, Balvinder S. Handa, Worrapong Kit-Anan, Filippo Perbellini, Rachel C. Myles, Daniel J. Stuckey, Michael Dunne, Mayooran Shanmuganathan, Nicholas S. Peters, Fu Siong Ng, Florian Weinberger, Cesare M. Terracciano, Godfrey L. Smith, Thomas Eschenhagen, Sian E. Harding
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordin
Externí odkaz:
https://doaj.org/article/5f7e39207cc8495596ab20ad1eee6e60
Autor:
Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifyi
Externí odkaz:
https://doaj.org/article/3121859689094ac79bf739761e7891fe
Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and s
Autor:
Qasim A. Majid, Annabelle T. R. Fricker, David A. Gregory, Natalia Davidenko, Olivia Hernandez Cruz, Richard J. Jabbour, Thomas J. Owen, Pooja Basnett, Barbara Lukasiewicz, Molly Stevens, Serena Best, Ruth Cameron, Sanjay Sinha, Sian E. Harding, Ipsita Roy
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial infarction (MI), arrhythmias
Externí odkaz:
https://doaj.org/article/8b3f79ae35c44aadac930a8f455de3e1