Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Autor: Peter P. Zandi, Lisa Jones, Aartjan T.F. Beekman, Christine Fraser, Andreas J. Forstner, Nese Direk, Mark Lathrop, Jesper Krogh, Merete Nordentoft, Bradley T. Webb, Yihan Li, Michael Bauer, Qingqin S. Li, Daniel J. Smith, Carsten Horn, Robert C. Thompson, René Breuer, Eli A. Stahl, David A. Collier, Richard Williamson, Boomsma, Dorret, I, Céline S. Reinbold, Laura J. Scott, Manolis Kogevinas, Jacob Lawrence, Caroline Hayward, Nicholas J. Schork, Penelope A. Lind, Wade H. Berrettini, John B. Vincent, Toni-Kim Clarke, Henry Voelzke, Stacy Steinberg, Hreinn Stefansson, Dean F. MacKinnon, Thorgeir E. Thorgeirsson, Niamh Mullins, Esben Agerbo, Rudolf Uher, Christina M. Hultman, Pamela A. F. Madden, Eva C. Schulte, Matthew Flickinger, Sebastian Zöllner, Kenneth S. Kendler, Urban Ösby, Enrique Castelao, Michael John Owen, Colm O'Dushlaine, Jens Treutlein, Joanna Hauser, Markus M. Noethen, Erin N. Smith, James McKay, Sandra Van der Auwera, Erin C. Dunn, Steven P. Hamilton, Martin Schalling, Helmut Vedder, Katherine Gordon-Smith, Fabio Rivas, Matthias Nauck, James B. Potash, Morten Mattingsdal, Ling Shen, Tim B. Bigdeli, Kimberly Chambert, Volker Arolt, Daniel L. Koller, Annelie Nordin Adolfsson, Na Cai, Nicholas G. Martin, Carlos N. Pato, Georg Homuth, Jonas Bybjerg-Grauholm, Alexander Teumer, Wesley K. Thompson, Hamel Patel, Jian Yang, Margit Burmeister, Frank Bellivier, Jodie N. Painter, Enda M. Byrne, Margarita Rivera, Nicholas John Craddock, Tatiana Foroud, Shaun Purcell, Paul D. Shilling, David Craig, Vanessa Kiyomi Ota, Michael Boehnke, Devin Absher, Stéphane Jamain, Anne Farmer, Yunpeng Wang, Ole Mors, William A. Scheftner, Jack D. Barchas, Robert Maier, Stanley J. Watson, Allan H. Young, Baptiste Couvy-Duchesne, Jakob Grove, Rick Jansen, John P. Rice, Gerome Breen, Eske M. Derks, Ingrid Melle, Tiffany A. Greenwood, Manuel Mattheisen, Bernard Ng, Edward M. Scolnick, Stefan Kloiber, Lili Milani, Yuri Milaneschi, Fermín Mayoral, Engilbert Sigurdsson, Sarah E. Medland, Wolfgang Maier, Alan F. Schatzberg, Myrna M. Weissman, Jun Li, John R. Kelsoe, Eric Jorgenson, Grant C.B. Sinnamon, Preben Bo Mortensen, Jana Strohmaier, William Byerley, Michel G. Nivard, Richard M. Myers, Evelin Mihailov, Gustavo Turecki, Benjamin S. Pickard, Ian J. Deary, Bernhard T. Baune, Marian L. Hamshere, Stephanie H. Witt, Patrick F. Sullivan, Jennifer L. Moran, Farnush Farhadi Hassan Kiadeh, Cathryn M. Lewis, Srdjan Djurovic, Ian B. Hickie, Hans J. Grabe, Helena Gaspar, Francis J. McMahon, Catherine Schaefer, Guy A. Rouleau, Sandra Meier, Derek W. Morris, Tõnu Esko, Wouter J. Peyrot, Markus Schwarz, Silviu-Alin Bacanu, Adam Wright, Melvin G. McInnis, Elaine K. Green, Douglas M. Ruderfer, Danielle Posthuma, Franziska Degenhardt, Per Qvist, Henriette N. Buttenschøn, Jolanta Lissowska, Stephan Ripke, Nicholas Bass, Giorgio Pistis, Emma M. Quinn, Shantel Weinsheimer, Howard J. Edenberg, Sintia Iole Belangero, Charles Curtis, Ashley R. Winslow, Tracy M. Air, Johannes H. Smit, Isaac S. Kohane, Wei Xu, Pamela B. Mahon, Neonila Szeszenia-Dabrowska, Gonneke Willemsen, Ivan Nikolov, Sven Cichon, Gregory E. Crawford, David M. Hougaard, E.J.C. de Geus, Klaus Berger, Evaristus A. Nwulia, Fernando S. Goes, Pablo Cervantes, Udo Dannlowski, Rolf Adolfsson, Thomas G. Schulze, Bruno Etain, Mark J. Adams, Thomas Hansen, Hugh Gurling, Fan Guo Meng, Judith A. Badner, Julien Bryois, Mateus Jose Abdalla Diniz, Rodrigo A. Bressan, Radhika Kandaswamy, Josef Frank, I. Nicol Ferrier, Bertram Mueller-Myhsok, Manuel A. R. Ferreira, Marion Leboyer, Futao Zhang, Valentina Moskvina, Patrik K. E. Magnusson, Laura M. Huckins, Douglas Blackwood, Michael Gill, Jianxin Shi, Dale R. Nyholt, Nancy L. Pedersen, André G. Uitterlinden, Henning Tiemeier, Vassily Trubetskoy, Scott D. Gordon, Ian Jones, Grant W. Montgomery, Martin Preisig, Cristiana Cruceanu, Sara A. Paciga, Lena Backlund, Abdel Abdellaoui, Andres Metspalu, Gunnar Morken, Marcus Ising, Sascha B. Fischer, Lilijana Oruc, Sian Caesar, Sarah Kittel-Schneider, Thalia C. Eley, Vihra Milanova, Thomas Werge, Andrew Heath, Katherine E. Tansey, Thomas W. Muehleisen, Jane H. Christensen, Chunyu Liu, Mikael Landén, Douglas F. Levinson, Julia Kraft, Juergen Wellmann, Coleman, Jonathan R., I, Peng Zhang, Glyn Lewis, Henning Teismann, Hamdi Mbarek, Carsten Bøcker Pedersen, Szabolcs Szelinger, Alexander Viktorin, Paul Brennan, Brenda W.J.H. Penninx, Maciej Trzaskowski, Yang Wu, Katharina Domschke, John Strauss, Hilary K. Finucane, Detelina Grozeva, Peter Holmans, Saira Saeed Mirza, Ole A. Andreassen, John I. Nurnberger, Lynsey S Hall, Till F. M. Andlauer, Sara Mostafavi, Andreas Reif, Joanna M. Biernacka, Christine Søholm Hansen, Hualin S. Xi, Stephen Newhouse, William E. Bunney, Andrew M. McIntosh, Anna Maaser, Enrico Domenici, Shyn, Stanley, I, Gail Davies, Warren W. Kretzschmar, Simone de Jong, Lucía Colodro-Conde, Pippa A. Thomson, Francis M. Mondimore, Martin Hautzinger, Cinnamon S. Bloss, Fabian Streit, James L. Kennedy, Erik Pettersson, Peter M. Visscher, Valentina Escott-Price, Donald J. MacIntyre, Johannes Schumacher, Kevin A. McGhee, Divya Mehta, Naomi R. Wray, Robert A. Schoevers, John A. Rice, Jordan W. Smoller, Anders D. Børglum, Susanne Lucae, Jorge A. Quiroz, Daniel Umbricht, Jouke-Jan Hottenga, Kari Stefansson, Marcella Rietschel, Zoltán Kutalik, Sarah E. Bergen, Paul F. O'Reilly, Amanda Dobbyn, Michael Conlon O'Donovan, Falk W. Lohoff, Caroline M. Nievergelt, David J. Porteous, Matthew Traylor, Brien P. Riley, Roy H. Perlis, J. Raymond DePaulo, Martin Alda, James A. Knowles, Cristiano Noto, Keith Matthews, Mark A. Frye, Patrick J. McGrath, Roseann E. Peterson, David St Clair, Roel A. Ophoff, William Coryell, Peter McGuffin, Andiara Calado Saloma Rodrigues, Elliot S. Gershon, Conor V. Dolan, Janice M. Fullerton, Weihua Guan, Niklas Långström, Pamela Sklar, Paul Lichtenstein, Per Hoffmann, Ary Gadelha, Alan W. McLean, Andrew McQuillin, Philip B. Mitchell, Huda Akil, Piotr M. Czerski, Michael Steffens, Hogni Oskarsson, Soumya Raychaudhuri, Marcos L. Santoro, Elisabeth B. Binder, Christel M. Middeldorp, Jose G. Para, Jurgen Del-Favero, Vishwajit L. Nimgaonkar, Peter R. Schofield, Stefan Herms, Marie Bækvad-Hansen, Andrea Pfennig, Albert M. van Hemert, Jutta Kammerer-Ciernioch, Adebayo Anjorin, Sara Paciga, William Lawson, George Kirov, Aiden Corvin, Maria Grigoroiu-Serbanescu, Marianne Giørtz Pedersen, Jonathan Marchini, Markus Leber, Maria Hipolito, Louise Frisén, Margitta Borrmann-Hassenbach, Amanda Elkin

Publikováno v: Communications Biology
Communications biology 1(1), 163 (2018). doi:10.1038/s42003-018-0155-y
Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)
Communications biology, vol 1, iss 1
bioRxiv
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Abdellaoui, A, Beekman, A T F, Dolan, C V, Hottenga, J J, Jansen, R, Mbarek, H, Milaneschi, Y, Nivard, M G, Posthuma, D, Boomsma, D I, de Geus, E J C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O`Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, 163, pp. 1-10 . https://doi.org/10.1038/s42003-018-0155-y
de Jong, S, Diniz, M J A, Saloma, A, Gadelha, A, Santoro, M L, Ota, V K, Noto, C, Curtis, C, Newhouse, S J, Patel, H, Hall, L S, O Reilly, P F, Belangero, S I, Bressan, R A, Breen, G & Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium (Per Qvist and Preben Bo Mortensen, members of-) 2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications Biology, vol. 1, 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications biology, vol. 1, pp. 163
Communications biology, 1:163. Nature Publishing Group
COMMUNICATIONS BIOLOGY
Communications biology, 1:163, 1-10. Nature Research
2018, ' Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder ', Communications biology, vol. 1, pp. 163 . https://doi.org/10.1038/s42003-018-0155-y
Communications Biology, 1(1):163. Springer Nature

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8e31d0d65994c29da2992d71dc1c70
https://hdl.handle.net/1956/19697

Familiality of postpartum depression in unipolar disorder: results of a family study

Autor: Liz Forty, Lisa Jones, Stuart Macgregor, Sian Caesar, Caroline Cooper, Andrea Hough, Laura Dean, Subodh Dave, Anne Farmer, Peter McGuffin, Shyama Brewster, Nick Craddock, Ian Jones

Publikováno v: ResearcherID

OBJECTIVE: The authors previously reported strong evidence for familial aggregation of postpartum (puerperal) psychotic episodes in women with bipolar disorder. The authors here examine whether vulnerability to postpartum triggering of depressive epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f4bf2a39f7c40cf9c56f033b5774d9
https://ora.ox.ac.uk/objects/uuid:0d02e1f7-61f4-41a5-8210-d78734677718

Reducing the Hypomania Checklist (HCL-32) to a 16-item version

Autor: Liz Forty, Lisa Jones, Christine Fraser, Katherine Gordon-Smith, Daniel J. Smith, Mark James Kelly, Sian Caesar, Emma Barnes, Emily Griffiths, Nicholas John Craddock, Ian Jones

Publikováno v: Journal of Affective Disorders. 124:351-356

Background The under-recognition of hypomanic symptoms by both clinicians and patients is a major clinical problem which contributes to misdiagnosis and diagnostic delay in patients with bipolar disorder. The recent development of validated screening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698e697a9db95629aab0323f408ce6d
https://doi.org/10.1016/j.jad.2010.01.004

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

Autor: Anne Farmer, Elaine K. Green, Nicholas John Craddock, M. J. Owen, Christine Fraser, Ian Jones, Michael Conlon O'Donovan, Marian L. Hamshere, Peter McGuffin, George Kirov, Valentina Moskvina, Liz Forty, Detelina Grozeva, Peter Holmans, E. Russell, Ivan Nikolov, Sian Caesar, Lisa Jones, Katherine Gordon-Smith

Publikováno v: Molecular Psychiatry

Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in general, and the mood and psychotic disorders in particular. Strong evidence (P=7.0 × 10(-7)) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aa6b2c5c6de316d6118a27088bb698
http://europepmc.org/articles/PMC3011210

Identifying hypomanic features in major depressive disorder using the hypomania checklist (HCL-32)

Autor: Christine Fraser, Katherine Gordon-Smith, Liz Forty, Ian Jones, Daniel J. Smith, Sian Caesar, Lisa Jones, Nicholas John Craddock

Publikováno v: Journal of Affective Disorders. 114:68-73

Background Recent studies have challenged the traditional unipolar/bipolar divide with increasing support for a more dimensional view of affective disorders. We here examine the occurrence of hypomanic symptoms in individuals with a history of major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777df4c4668a1609fca50c4836d70201
https://doi.org/10.1016/j.jad.2008.07.017