Zobrazeno 1 - 10
of 508
pro vyhledávání: '"Siamon, Gordon"'
Autor:
Federica Orsenigo, Alexander Stewart, Clare P. Hammer, Emma Clarke, Daniel Simpkin, Hossameldin Attia, Timothy Rockall, Siamon Gordon, Fernando O. Martinez
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114352- (2024)
Summary: Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is important in diagnosing hematological disorders and inflammatory pathologies and designing therapeutic tools. CSF1R is a reliable marker to identify all cir
Externí odkaz:
https://doaj.org/article/c0e9483bd0c045cb90c8fa0245a1e38f
Publikováno v:
Cells, Vol 13, Iss 16, p 1378 (2024)
The mononuclear phagocyte system includes monocytes, macrophages, some dendritic cells, and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow hematopoietic
Externí odkaz:
https://doaj.org/article/648ee18fca41438fadac4a9cf561ec64
Autor:
Chinaemerem U. Onyishi, Guillaume E. Desanti, Alex L. Wilkinson, Samuel Lara-Reyna, Eva-Maria Frickel, Gyorgy Fejer, Olivier D. Christophe, Clare E. Bryant, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is recognised and phagocy
Externí odkaz:
https://doaj.org/article/d574524e28824efda336edb4bafa128e
Autor:
Tai-Ying Chu, Céline Zheng-Gérard, Kuan-Yeh Huang, Yu-Chi Chang, Ying-Wen Chen, Kuan-Yu I, Yu-Ling Lo, Nien-Yi Chiang, Hsin-Yi Chen, Martin Stacey, Siamon Gordon, Wen-Yi Tseng, Chiao-Yin Sun, Yen-Mu Wu, Yi-Shin Pan, Chien-Hao Huang, Chun-Yen Lin, Tse-Ching Chen, Kamel El Omari, Marilina Antonelou, Scott R. Henderson, Alan Salama, Elena Seiradake, Hsi-Hsien Lin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Activation of neutrophil leukocytes is tightly regulated, and it is important to understand the molecular mechanisms of their response to physiological and pathological stimuli. Here authors show that the adhesion molecule G protein-coupled receptor
Externí odkaz:
https://doaj.org/article/b5cfd5e14a0d4c268333705e3a855d3c
Autor:
Antoni Olona, Subhankar Mukhopadhyay, Charlotte Hateley, Fernando O. Martinez, Siamon Gordon, Jacques Behmoaras
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Cell membrane fusion and multinucleation in macrophages are associated with physiologic homeostasis as well as disease. Osteoclasts are multinucleated macrophages that resorb bone through increased metabolic activity resulting from cell fusi
Externí odkaz:
https://doaj.org/article/2fd5b548491e4a29a5558064d1059ef3
Autor:
Priyal Mistry, Fatima Barmania, Juanita Mellet, Kimberly Peta, Adéle Strydom, Ignatius M. Viljoen, William James, Siamon Gordon, Michael S. Pepper
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new beta coronavirus that emerged at the end of 2019 in the Hubei province of China. SARS-CoV-2 causes coronavirus disease 2019 (COVID-19) and was declared a pandemic by the World Heal
Externí odkaz:
https://doaj.org/article/5c93c220ff244b9fa4f00ba879859e85
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mycobacterium tuberculosis infects primarily macrophages in the lungs. Infected macrophages are surrounded by other immune cells in well organised structures called granulomata. As part of the response to TB, a type of macrophage loaded with lipid dr
Externí odkaz:
https://doaj.org/article/e3055dfc8401479abfc4d9c14e76ef53
Autor:
Mankgopo Magdeline Kgatle, Ismaheel Opeyemi Lawal, Gabriel Mashabela, Tebatso Moshoeu Gillian Boshomane, Palesa Caroline Koatale, Phetole Walter Mahasha, Honest Ndlovu, Mariza Vorster, Hosana Gomes Rodrigues, Jan Rijn Zeevaart, Siamon Gordon, Pedro Moura-Alves, Mike Machaba Sathekge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machi
Externí odkaz:
https://doaj.org/article/7b02e6b7c0d747eebc36212c4fb89a82
Autor:
David G. Russell, Siamon Gordon
An overview of the current understanding of how phagocytes recognize and respond to potentially pathogenic microbes.
Autor:
Scott R Henderson, Harry Horsley, Paul Frankel, Maryam Khosravi, Talya Goble, Stephen Carter, Marilina Antonelou, Rhys D R Evans, Xiang Zhang, Tai-Ying Chu, Hsi-Hsien Lin, Siamon Gordon, Alan David Salama
Publikováno v:
Annals of the Rheumatic Diseases. 82:848-856
ObjectivesGranulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and m