Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Siamak Cyrus Khojasteh-Bakht"'
Autor:
Jason Halladay, Cornelis E. C. A. Hop, Erlie Marie Delarosa, Jane R. Kenny, Chenghong Zhang, Siamak Cyrus Khojasteh-Bakht, Susan Wong
Publikováno v:
Drug Metabolism Letters. 3:125-129
In the early stages of drug discovery, the formation of reactive metabolites is often assessed by co-incubating the drug in liver microsomes with a trapping agent in the presence of NADPH. Our group assessed the capability of commonly used trapping a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3212b9044030cbf189ac29b93cd5bedd
https://doi.org/10.2174/187231209788654126
https://doi.org/10.2174/187231209788654126
Autor:
Siamak Cyrus Khojasteh-Bakht, Fran Lai
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 814(2)
In vitro metabolic stability studies are performed routinely in drug discovery to determine the rate of metabolism as well as the metabolic fate of compounds. These studies are labor intensive, involving incubation of the compound with a biological m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfb2018490f9bf3e7fdd3c4eb8c8799
https://pubmed.ncbi.nlm.nih.gov/15639443
https://pubmed.ncbi.nlm.nih.gov/15639443