Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Siamak Cyrus Khojasteh"'
Autor:
Teresa Mulder, Siamak Cyrus Khojasteh, Jason Halladay, Patrick M. Dansette, James P. Driscoll, Jasleen K. Sodhi, Erlie Marie Delarosa
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1553 (2017)
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1553 (2017)
In some cases, the formation of reactive species from the metabolism of xenobiotics has been linked to toxicity and therefore it is imperative to detect potential bioactivation for candidate drugs during drug discovery. Reactive species can covalentl
Autor:
Jason Halladay, Cornelis E. C. A. Hop, Erlie Marie Delarosa, Jane R. Kenny, Chenghong Zhang, Siamak Cyrus Khojasteh-Bakht, Susan Wong
Publikováno v:
Drug Metabolism Letters. 3:125-129
In the early stages of drug discovery, the formation of reactive metabolites is often assessed by co-incubating the drug in liver microsomes with a trapping agent in the presence of NADPH. Our group assessed the capability of commonly used trapping a
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions,
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
Metabolism is the major elimination pathway of a drug from the body. Drug metabolizing enzymes (DMEs) are mainly present in the liver, intestine, and blood and are responsible for converting lipophilic drugs to more hydrophilic compounds to facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556ce027a1040089af35b9312e8d7a59
https://doi.org/10.1007/978-1-4419-5629-3_2
https://doi.org/10.1007/978-1-4419-5629-3_2
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
Absorption, distribution, metabolism, and excretion (ADME) properties such as absorption, clearance, and volume of distribution are strongly influenced by physicochemical parameters. A lot of retrospective analyses have been performed to identify tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd6f9c64883106554e8dd76b7f2f8ee6
https://doi.org/10.1007/978-1-4419-5629-3_9
https://doi.org/10.1007/978-1-4419-5629-3_9
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6c4a0a6a9caaa776290bddf2a583a6d
https://doi.org/10.1007/978-1-4419-5629-3_3
https://doi.org/10.1007/978-1-4419-5629-3_3
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
The terms metabolism and biotransformation are used interchangeably in this book. As described in Chap. 2, metabolism is a major route of elimination of drugs from the body and, in general, results in the formation of metabolites that are more polar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33c46f65c6093a467bc204567adc050
https://doi.org/10.1007/978-1-4419-5629-3_6
https://doi.org/10.1007/978-1-4419-5629-3_6
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::621ba8c4f86ec199e34091f2eac3454d
https://doi.org/10.1007/978-1-4419-5629-3_1
https://doi.org/10.1007/978-1-4419-5629-3_1
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c00fbfae67af33bf3ff9dabe1198bc3b
https://doi.org/10.1007/978-1-4419-5629-3_12
https://doi.org/10.1007/978-1-4419-5629-3_12
Publikováno v:
Drug Metabolism and Pharmacokinetics Quick Guide ISBN: 9781441956286
The breath and predictive power of in silico ADME tools has increased rapidly during the last 10 years. The quality of many models is such that they can successfully influence decision making in drug discovery and development. In drug discovery they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::720b28383dcda453b1f590a49b062a75
https://doi.org/10.1007/978-1-4419-5629-3_10
https://doi.org/10.1007/978-1-4419-5629-3_10