Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial

Autor: Claire N. Harrison, Jyoti Nangalia, Rebecca Boucher, Aimee Jackson, Christina Yap, Jennifer O'Sullivan, Sonia Fox, Isaak Ailts, Amylou C. Dueck, Holly L. Geyer, Ruben A. Mesa, William G. Dunn, Eugene Nadezhdin, Natalia Curto-Garcia, Anna Green, Bridget Wilkins, Jason Coppell, John Laurie, Mamta Garg, Joanne Ewing, Steven Knapper, Josephine Crowe, Frederick Chen, Ioannis Koutsavlis, Anna Godfrey, Siamak Arami, Mark Drummond, Jennifer Byrne, Fiona Clark, Carolyn Mead-Harvey, Elizabeth Joanna Baxter, Mary Frances McMullin, Adam J. Mead

Publikováno v: Harrison, C N, Nangalia, J, Boucher, R, Jackson, A, Yap, C, O'Sullivan, J, Fox, S, Ailts, I, Dueck, A C, Geyer, H L, Mesa, R A, Dunn, W G, Nadezhdin, E, Curto-Garcia, N, Green, A, Wilkins, B, Coppell, J, Laurie, J, Garg, M, Ewing, J, Knapper, S, Crowe, J, Chen, F, Koutsavlis, I, Godfrey, A, Arami, S, Drummond, M, Byrne, J, Clark, F, Mead-Harvey, C, Baxter, E J, McMullin, M F & Mead, A J 2023, ' Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial ', Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology . https://doi.org/10.1200/JCO.22.01935

PURPOSE Polycythemia vera (PV) is characterized by JAK/STAT activation, thrombotic/hemorrhagic events, systemic symptoms, and disease transformation. In high-risk PV, ruxolitinib controls blood counts and improves symptoms. PATIENTS AND METHODS MAJIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fd7ce9bbaa9e48083024978d50aea3
https://pure.qub.ac.uk/en/publications/fcda774d-04e8-4597-8a71-76d0585a46e6

Improvement in mortality of hospitalized patients with hematological malignancies in the 2nd wave of COVID-19 in the UK: experience of a large London NHS trust

Autor: Sameer Gandhi, David Foldes, Richard Hinton, George Nesr, Agapi Parcharidou, Rachael Medland, Catherine Garnett, Huseini Kagdi, Siamak Arami, Vaitsa Katsomitrou, Joel James Robert McCay, Hau Wui Sim

Publikováno v: Leukemia & Lymphoma. 63:227-230

The UK has been severely affected by the COVID-19 pandemic with over 4.4 million cases and over 127,000 deaths to date (www.gov.uk accessed 17 May 2021). Patients with hematological malignancies wh...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52c388fa5027b739430edfb347458f5
https://doi.org/10.1080/10428194.2021.1973671

Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm

Autor: Sebastian Francis, Jaymathi Dhanapal, Lee Bond, Beth Psaila, Louise Wallis, Jennifer O'Sullivan, Anna L. Godfrey, Natalia Curto-Garcia, Andrew J. Innes, Richard Szydlo, Andrew McGregor, Laura Munro, Pratap Neelakantan, Siamak Arami, Rebecca Frewin, Adam J. Mead, Hayder Hussein, Frances Wadelin, James Russell, Steven Knapper, Peter Dyer, John Willan, Chun Huat Teh, Richard A. Salisbury, Mallika Sekhar, Manish Jain, Claire N. Harrison, Tim C. P. Somervaille, Shivani Joshi, C Cargo, Paolo Polzella, Mamta Garg, Andrew S Duncombe, Sarah Burns, Mary Frances McMullin, Dragana Milojkovic, Frederick Chen

Publikováno v: Leukemia
Salisbury, R A, Curto-Garcia, N, O’Sullivan, J, Chen, F, Polzella, P, Godfrey, A L, Russell, J, Knapper, S, Willan, J, Frewin, R, Joshi, S, Arami, S, Burns, S, Teh, C H, Wadelin, F, Dhanapal, J, Neelakantan, P, Milojkovic, D, Psaila, B, Szydlo, R, Francis, S, Cargo, C, Jain, M, McGregor, A, Wallis, L, Duncombe, A, Hussein, H, Dyer, P, Munro, L, Bond, L, McMullin, M F, Somervaille, T C P, Garg, M, Sekhar, M, Harrison, C, Mead, A J & Innes, A J 2021, ' Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm ', Leukemia . https://doi.org/10.1038/s41375-021-01143-2

Funder: Cancer Research UK (CRUK); doi: https://doi.org/10.13039/501100000289
Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cc49236661f92f59956750192b753b

Outcome of hospitalized patients with hematological malignancies and COVID-19 infection in a large urban healthcare trust in the United Kingdom

Autor: Marife Colis, Catherine Garnett, Siamak Arami, George Nesr, Rincy Koshy, Richard Hinton, Kamala Gurung, Huseini Kagdi, David Foldes, James Phillips, Vaitsa Katsomitrou, Zahbia Saleem, Elvis Aduwa, Ravi Bimolah, Christopher Bailey, Tracy Hui

Publikováno v: Leukemia & Lymphoma

Infection with SARS-CoV-2 is a significant and highly topical worldwide health and social crisis. To date over 25 million cases of COVID-19 infection have been reported globally with greater than 9...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13b6e1b81d73f31575bbe612a622554
https://pubmed.ncbi.nlm.nih.gov/33167718

Plasmacytoid lymphocytes in SARS‐CoV ‐2 infection (Covid‐19)

Autor: Barbara J. Bain, David Foldes, Siamak Arami, Richard Hinton

Publikováno v: American Journal of Hematology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70090cf30d5d162e4d54c88ff2decdb
https://doi.org/10.1002/ajh.25834