Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sia V. Lindskrog"'
Autor:
Sia V. Lindskrog, Sofie S. Schmøkel, Iver Nordentoft, Philippe Lamy, Michael Knudsen, Frederik Prip, Trine Strandgaard, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
Publikováno v:
European Urology Open Science, Vol 51, Iss , Pp 78-88 (2023)
Background: Current bulk transcriptomic classification systems for bladder cancer do not consider the level of intratumor subtype heterogeneity. Objective: To investigate the extent and possible clinical impact of intratumor subtype heterogeneity acr
Externí odkaz:
https://doaj.org/article/a4a32cfb28414004a84725a2cbf068dc
Autor:
Sofie S. Schmøkel, Iver Nordentoft, Sia V. Lindskrog, Philippe Lamy, Michael Knudsen, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTThis paper provides a laboratory workflow for single-nucleus RNA-sequencing (snRNA-seq) including a protocol for gentle nuclei isolation from fresh frozen tumor biopsies, making it possible to analyze biobanked material. To develop this proto
Externí odkaz:
https://doaj.org/article/2e7747d78fe2400793b4ae335a10b1b4
Autor:
Emil Christensen, Iver Nordentoft, Karin Birkenkamp-Demtröder, Sara K. Elbæk, Sia V. Lindskrog, Ann Taber, Tine G. Andreasen, Trine Strandgaard, Michael Knudsen, Philippe Lamy, Mads Agerbæk, Jørgen B. Jensen, Lars Dyrskjøt
Publikováno v:
Christensen, E, Nordentoft, I, Birkenkamp-Demtroder, K, Elbæk, S K, Lindskrog, S V, Taber, A, Andreasen, T G, Strandgaard, T, Knudsen, M, Lamy, P, Agerbæk, M, Jensen, J B & Dyrskjøt, L 2023, ' Cell-free urine-and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer ', Clinical Cancer Research, vol. 29, no. 8, pp. 1582–1591 . https://doi.org/10.1158/1078-0432.CCR-22-3250
Purpose: To investigate the use of plasma and urine DNA mutation analysis for predicting neoadjuvant chemotherapy (NAC) response and oncological outcome in patients with muscle-invasive bladder cancer. Experimental Design: Whole-exome sequencing of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf1f58ca57cdc96542ccdf2f65dc41d
https://doi.org/10.1158/1078-0432.ccr-22-3250
https://doi.org/10.1158/1078-0432.ccr-22-3250
Autor:
Lars Dyrskjøt, Jørgen B. Jensen, Mads Agerbæk, Philippe Lamy, Michael Knudsen, Trine Strandgaard, Tine G. Andreasen, Ann Taber, Sia V. Lindskrog, Sara K. Elbæk, Karin Birkenkamp-Demtröder, Iver Nordentoft, Emil Christensen
Clinical data and follow-up data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5455250d6214eb3d469c6019dfbe49c5
https://doi.org/10.1158/1078-0432.22633004
https://doi.org/10.1158/1078-0432.22633004
Autor:
Lars Dyrskjøt, Jørgen B. Jensen, Mads Agerbæk, Philippe Lamy, Michael Knudsen, Trine Strandgaard, Tine G. Andreasen, Ann Taber, Sia V. Lindskrog, Sara K. Elbæk, Karin Birkenkamp-Demtröder, Iver Nordentoft, Emil Christensen
Supplementary Fig. 1. Overview of sample availability and in-silico analysis of the limit of detection for the applied methodology.Supplementary Fig. 2. Comparison between mutations observed in primary and residual tumors at radical cystectomy (RC).S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0801f108c799ca6bb851bf70e519d51b
https://doi.org/10.1158/1078-0432.22633010.v1
https://doi.org/10.1158/1078-0432.22633010.v1
Autor:
Lars Dyrskjøt, Jørgen B. Jensen, Mads Agerbæk, Philippe Lamy, Michael Knudsen, Trine Strandgaard, Tine G. Andreasen, Ann Taber, Sia V. Lindskrog, Sara K. Elbæk, Karin Birkenkamp-Demtröder, Iver Nordentoft, Emil Christensen
Purpose:To investigate the use of plasma and urine DNA mutation analysis for predicting neoadjuvant chemotherapy (NAC) response and oncological outcome in patients with muscle-invasive bladder cancer.Experimental Design:Whole-exome sequencing of tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1599c159ac6f0ceacce3351ca061b11e
https://doi.org/10.1158/1078-0432.c.6533092
https://doi.org/10.1158/1078-0432.c.6533092
Autor:
Sia V. Lindskrog, Sofie S. Schmøkel, Iver Nordentoft, Philippe Lamy, Michael Knudsen, Frederik Prip, Trine Strandgaard, Jørgen Bjerggaard Jensen, Lars Dyrskjøt
SummaryCurrent transcriptomic classification systems for bladder cancer do not consider the level of intra-tumor subtype heterogeneity. Here we present an investigation of the extent and possible clinical impact of intra-tumor heterogeneity across ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ac14ea2b938be71d1841daf8c2fe82
https://doi.org/10.1101/2022.10.27.513983
https://doi.org/10.1101/2022.10.27.513983
Autor:
Carolyn D. Hurst, Guo Cheng, Fiona M. Platt, Mauro A.A. Castro, Nour-al-dain S. Marzouka, Pontus Eriksson, Emma V.I. Black, Olivia Alder, Andrew R.J. Lawson, Sia V. Lindskrog, Julie E. Burns, Sunjay Jain, Jo-An Roulson, Joanne C. Brown, Jan Koster, A. Gordon Robertson, Inigo Martincorena, Lars Dyrskjøt, Mattias Höglund, Margaret A. Knowles
Publikováno v:
Cell Reports Medicine
Hurst, C D, Cheng, G, Platt, F M, Castro, M A A, Marzouka, N A D S, Eriksson, P, Black, E V I, Alder, O, Lawson, A R J, Lindskrog, S V, Burns, J E, Jain, S, Roulson, J A, Brown, J C, Koster, J, Robertson, A G, Martincorena, I, Dyrskjøt, L, Höglund, M & Knowles, M A 2021, ' Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight ', Cell Reports Medicine, vol. 2, no. 12, 100472 . https://doi.org/10.1016/j.xcrm.2021.100472
Cell Reports Medicine, 2(12):100472. Cell Press
Hurst, C D, Cheng, G, Platt, F M, Castro, M A A, Marzouka, N A D S, Eriksson, P, Black, E V I, Alder, O, Lawson, A R J, Lindskrog, S V, Burns, J E, Jain, S, Roulson, J A, Brown, J C, Koster, J, Robertson, A G, Martincorena, I, Dyrskjøt, L, Höglund, M & Knowles, M A 2021, ' Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight ', Cell Reports Medicine, vol. 2, no. 12, 100472 . https://doi.org/10.1016/j.xcrm.2021.100472
Cell Reports Medicine, 2(12):100472. Cell Press
Summary Understanding the molecular determinants that underpin the clinical heterogeneity of non-muscle-invasive bladder cancer (NMIBC) is essential for prognostication and therapy development. Stage T1 disease in particular presents a high risk of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a08008fa4416dc466e726ad6ba197a8
http://www.scopus.com/inward/record.url?scp=85121481080&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85121481080&partnerID=8YFLogxK
Autor:
Sia V. Lindskrog, Sofie S. Schmøkel, Iver Nordentoft, Philippe Lamy, Michael Knudsen, Jørgen B. Jensen, Lars Dyrskjøt
Publikováno v:
Cancer Research. 82:3483-3483
Introduction: Single cell technologies now make it possible to study tumor ecosystems at single cell resolution and may improve our biological understanding of disease aggressiveness and tumor heterogeneity. Whereas single-cell RNA-sequencing of clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a45b42ae0ca727c8bee0cf82408ffbd
https://doi.org/10.1158/1538-7445.am2022-3483
https://doi.org/10.1158/1538-7445.am2022-3483
Autor:
Ann Taber, Philippe Lamy, Iver Nodentoft, Emil Christensen, Frederik F. Prip, Sia V. Lindskrog, Karin Birkenkamp-Demtröder, Mads Agerbæk, Jørgen B. Jensen, Lars Dyrskjøt
Publikováno v:
Cancer Research. 79:459-459
Background: The interplay between carcinoma cells and their microenvironment plays an important part in cancer development, progression, metastasis and treatment efficacy. In bladder cancer, however, little is currently known about how the tumor micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f0ba42e788467b4dad5d44296968c4
https://doi.org/10.1158/1538-7445.am2019-459
https://doi.org/10.1158/1538-7445.am2019-459