Photoregulation of Gene Expression with Amantadine‐Modified Caged siRNAs through Host–Guest Interactions

Autor: Nannan Jing, Xinjing Tang, Xinli Fan, Jinhao Zhang

Publikováno v: Chemistry – A European Journal. 26:14002-14010

RNA interference is an essential and powerful tool for targeting and verifying specific gene functions. Conditional control of small interfering RNA (siRNA) activity, especially using light activation, is a potential method for regulating target gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd78b8d9282f3b5061382b99c70e402
https://doi.org/10.1002/chem.202003084

Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration

Autor: Jean-Louis Reymond, Susanna Zamolo, Marc Heitz, Sacha Javor

Publikováno v: Heitz, Marc; Zamolo, Susanna; Javor, Sacha; Reymond, Jean-Louis (2020). Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration. Bioconjugate chemistry, 31(6), pp. 1671-1684. American Chemical Society 10.1021/acs.bioconjchem.0c00231

Transfecting nucleic acids into various cells is a key procedure in biological research also envisioned for therapeutic applications. In our effort to obtain simple reagents that would be readily accessible from commercial building blocks, we recentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31231bc6b02e10f6dbc06ed7995db99
https://doi.org/10.1021/acs.bioconjchem.0c00231

Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury

Autor: Qiujun Liang, Yongbing Chen, Xiao Wang, Qiurong Deng, Rongying Zhu, Yiming Mao, Rujing Zhang, Shanzhou Duan, Lichen Yin

Publikováno v: Biomaterials Science. 8:3856-3870

siRNA-mediated RNA interference (RNAi) against inflammation-related genes provides a promising modality for the treatment of myocardial ischemia reperfusion (IR) injury, and its success is critically dependent on the development of efficient yet safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140e0318bfe0d530daacc14e457524b2
https://doi.org/10.1039/d0bm00631a

p24G1 Encoded by Grapevine Leafroll-Associated Virus 1 Suppresses RNA Silencing and Elicits Hypersensitive Response-Like Necrosis in Nicotiana Species

Autor: Wen-Ting Huang, Qi Zeng, Qi Wang, Qing Liu, Yuqin Cheng, Chen-Wei Zhang

Publikováno v: Viruses
Volume 12
Issue 10
Viruses, Vol 12, Iss 1111, p 1111 (2020)

Grapevine leafroll-associated virus 1 (GLRaV-1) is a major pathogen associated with grapevine leafroll disease. However, the molecular mechanisms underlying GLRaV-1 interactions with plant cells are unclear. Using Agrobacterium infiltration-mediated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7d6594fa2c1128c626a4204a561f31

Investigation of water-insoluble hydrophobic polyethylenimines as RNAi vehicles in chronic myeloid leukemia therapy

Autor: Hasan Uludaǧ, Xiaoyan Jiang, Aysha S. Ansari, Remant Bahadur K C

Publikováno v: Journal of biomedical materials research. Part AREFERENCES. 109(11)

The discovery of RNA interference (RNAi) more than two decades ago opened avenues for avant-garde cancer treatments that possess the ability to evade issues hampering current chemotherapeutic strategies, owing to its specific gene sequence-driven mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5404301aca1c2528e05fc86c1529328
https://pubmed.ncbi.nlm.nih.gov/33964112