The modified elevated gap interaction test: a novel paradigm to assess social preference

Autor: Chris I. de Zeeuw, Si-yang Yu, Jiawei Chen, Willem S. van Hoogstraten, Arn M. J. M. van den Maagdenberg, Laurens W. J. Bosman, Lieke Kros

Publikováno v: Open Biology, Vol 14, Iss 12 (2024)

Social deficits play a role in numerous psychiatric, neurological and neurodevelopmental disorders. Relating complex behaviour, such as social interaction, to brain activity remains one of the biggest goals and challenges in neuroscience. Availabilit

Externí odkaz: https://doaj.org/article/c4a4fd08258c4037959999aa9e907fd6

A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior

Autor: Xiaolu Wang, Si-yang Yu, Zhong Ren, Chris I. De Zeeuw, Zhenyu Gao

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

Delay eyeblink conditioning depends on the simplex lobule-interposed nucleus pathway in the cerebellum. Here, the authors show that the vermis-fastigial nucleus-medullary reticular nucleus pathway modulates the conditioned and unconditioned eyelid cl

Externí odkaz: https://doaj.org/article/151f776e63f24a17aeabddba240a1658

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Autor: Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu, Guangheng Zhu, Yi-Min She, Terry Cyr, Wenbin Fu, Guoqing Liu, Philip W. Connelly, Margaret L. Rand, Khosrow Adeli, John Freedman, Jeffrey E. Lee, Patrick Tso, Patrizia Marchese, W. Sean Davidson, Shaun P. Jackson, Cheng Zhu, Zaverio M. Ruggeri, Heyu Ni

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggr

Externí odkaz: https://doaj.org/article/0ce3127e01234b83a479b73aff61e66c

OptiFlex: Multi-Frame Animal Pose Estimation Combining Deep Learning With Optical Flow

Autor: Nico A Flierman, Si-Yang Yu, Maarten Kamermans, Sebastian Loyola, Chris I. De Zeeuw, Tycho M. Hoogland, XiaoLe Liu

Publikováno v: Frontiers in cellular neuroscience, 15:621252. Frontiers Media S.A.
Frontiers in Cellular Neuroscience, 15. Frontiers Media SA
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, 15:621252. Frontiers Media S.A.
Frontiers in Cellular Neuroscience, Vol 15 (2021)

Animal pose estimation tools based on deep learning have greatly improved animal behaviour quantification. These tools perform pose estimation on individual video frames, but do not account for variability of animal body shape in their prediction and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb87ceb62026dc32377946d12cbeba3
https://pure.amc.nl/en/publications/optiflex-multiframe-animal-pose-estimation-combining-deep-learning-with-optical-flow(d5302533-df4d-419c-b46a-f9f44543ae53).html

A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior

Autor: Xiaolu Wang, Si-yang Yu, Zhong Ren, Chris De Zeeuw, Zhenyu Gao

The cerebellum is crucial for various associative sensorimotor behaviors. Delay eyeblink conditioning (DEC) depends on the simplex lobule-interposed nucleus (IN) pathway, yet it is unclear how other cerebellar modules cooperate during this task. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0b808d24c0ff7f5c9f83e6ae837997f
https://doi.org/10.21203/rs.3.rs-43736/v1