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Akademický článek

Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy

Autor: Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

Publikováno v: BMJ Oncology, Vol 3, Iss 1 (2024)

Objective Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. We aimed to develop a predictive framework based on machine learning (ML) method

Externí odkaz: https://doaj.org/article/20e430b979254079aac5e5c334ae163c

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Akademický článek

Definition of a new blood cell count score for early survival prediction for non-small cell lung cancer patients treated with atezolizumab: Integrated analysis of four multicenter clinical trials

Autor: Jian-Guo Zhou, Ada Hang-Heng Wong, Haitao Wang, Su-Han Jin, Fangya Tan, Yu-Zhong Chen, Si-Si He, Gang Shen, Benjamin Frey, Rainer Fietkau, Markus Hecht, Shamus R. Carr, Ruihong Wang, Bo Shen, David S. Schrump, Hu Ma, Udo S. Gaipl

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

ImportanceBlood cell count test (BCT) is a robust method that provides direct quantification of various types of immune cells to reveal the immune landscape to predict atezolizumab treatment outcomes for clinicians to decide the next phase of treatme

Externí odkaz: https://doaj.org/article/0510a79ed4e94420ac663f83d39095e3

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Akademický článek

Elucidation of the Application of Blood Test Biomarkers to Predict Immune-Related Adverse Events in Atezolizumab-Treated NSCLC Patients Using Machine Learning Methods

Autor: Jian-Guo Zhou, Ada Hang-Heng Wong, Haitao Wang, Fangya Tan, Xiaofei Chen, Su-Han Jin, Si-Si He, Gang Shen, Yun-Jia Wang, Benjamin Frey, Rainer Fietkau, Markus Hecht, Hu Ma, Udo S. Gaipl

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

BackgroundDevelopment of severe immune-related adverse events (irAEs) is a major predicament to stop treatment with immune checkpoint inhibitors, even though tumor progression is suppressed. However, no effective early phase biomarker has been establ

Externí odkaz: https://doaj.org/article/5e92e0567a3346cc9a5c65ab03834cfe

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Akademický článek

Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy

Autor: Jian-Guo Zhou, Bo Liang, Jian-Guo Liu, Su-Han Jin, Si-Si He, Benjamin Frey, Ning Gu, Rainer Fietkau, Markus Hecht, Hu Ma, Udo S. Gaipl

Publikováno v: Cells, Vol 10, Iss 5, p 977 (2021)

The blockade of programmed cell death protein 1 (PD-1) as monotherapy has been widely used in melanoma, but to identify melanoma patients with survival benefit from anti-PD-1 monotherapy is still a big challenge. There is an urgent need for prognosti

Externí odkaz: https://doaj.org/article/1977582d266046ed8bedaa8a2a104bf9

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Development and validation of longitudinal c-reactive protein as dynamic response predictor for PD-L1 blockade in advanced NSCLC: Findings from four atezolizumab clinical trials

Autor: Jian-Guo Zhou, Xiaofei Chen, Ada Hang-Heng Wong, Haitao Wang, Fangya Tan, Si-Si He, Gang Shen, YunJia Wang, Ruihong Wang, Shamus R. Carr, Benjamin Frey, Rainer Fietkau, Markus Hecht, Hu Ma, David S. Schrump, Udo S Gaipl

Publikováno v: Journal of Clinical Oncology. 40:e21113-e21113

e21113 Background: Numerous studies suggested that pre-treatment C-reactive protein (CRP) is a survival predictive biomarker for cancer patients treated with anti-PD-(L)1 blockade. However, the application of longitudinal CRP levels as dynamic biomar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ab5e0a4bb8448c3ca6726af59941310
https://doi.org/10.1200/jco.2022.40.16_suppl.e21113

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329 Early blood cell count test (BCT) for survival prediction for non-small cell lung cancer patients treated with atezolizumab: integrated analysis of 4 multicenter clinical trials

Autor: Si-si He, Jian-Guo Zhou, Udo S. Gaipl, Markus Hecht, Bo Shen, Fangya Tan, Su-Han Jin, Hu Ma, Rainer Fietkau, Ada Hang-Heng Wong, Yu-Zhong Chen, Benjamin Frey, Haitao Wang, Gang Shen

Publikováno v: Journal for ImmunoTherapy of Cancer. 9:A355-A355

BackgroundImmune checkpoint inhibitor (ICI) therapy is a major breakthrough for non-small cell lung cancer (NSCLC) treatment given its high efficacy and tolerable toxicity. Although pre-treatment PD-L1 expression levels and tumor mutation burden (TMB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73f2b34b35f1597b5fc89d6f399f096b
https://doi.org/10.1136/jitc-2021-sitc2021.329

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The Relationship Between Phase Structure and Electrical Properties in (1 − x )(Bi0.5 Na0.5 TiO3 -Ba0.5 K0.5 TiO3 -BaTiO3 )- x K0.5 Na0.5 NbO3 Quaternary Lead-Free Piezoelectric Ceramics

Autor: Yejing Dai, Lao Xun, Shi-Zheng Zhang, Si-Si He

Publikováno v: Journal of the American Ceramic Society. 97:1283-1287

(1 − x)(0.85Bi0.5Na0.5TiO3–0.11Ba0.5K0.5TiO3–0.04BaTiO3)- xK0.5Na0.5NbO3 lead-free piezoelectric ceramics with x = 0.00, 0.02, 0.03, 0.04, 0.05, and 0.10 were prepared by a conventional solid state method. A coexistence of rhombohedral (R) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8b2a42c29d7acdb13fafa2977ff561a
https://doi.org/10.1111/jace.12760

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