Zobrazeno 1 - 10
of 631
pro vyhledávání: '"Si Shi"'
Autor:
Xiaoqi Mao, Jin Xu, Mingming Xiao, Chen Liang, Jie Hua, Jiang Liu, Wei Wang, Xianjun Yu, Qingcai Meng, Si Shi
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103200- (2024)
Currently, chemotherapy remains occupying a pivotal place in the treatment of pancreatic ductal adenocarcinoma (PDAC). Nonetheless, the emergence of drug resistance in recent years has limited the clinical efficacy of chemotherapeutic agents, especia
Externí odkaz:
https://doaj.org/article/52405a8f56004b489abd69e2f4ca4e76
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which ca
Externí odkaz:
https://doaj.org/article/88f6096983c64c97aa3a3f608213a448
Autor:
Heng Zhu, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105098- (2024)
Summary: Background: The widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. However, B cell heterogeneity in PDAC remains unexplored. Studying TIL-Bs in PDAC aims to identify new treatment strategi
Externí odkaz:
https://doaj.org/article/1f49f20bec0b41ff810d3b710542204e
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and its molecular mechanisms are unclear. Nucleolar and spindle-associated protein 1 (NUSAP1), an indispensable mitotic regulator, has been reported to be involved in t
Externí odkaz:
https://doaj.org/article/9e6a49fe37a546c680d3a23bf1b69e3f
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-29 (2023)
Abstract Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grown as a result of the widespread use of deep learning and machine learning in the healthcare sector and the availability
Externí odkaz:
https://doaj.org/article/cfbb1fe0bbb44dd3badf19fc5a91b729
Autor:
Mingming Xiao, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Jialin Li, Hang Xu, Yingjun Zhao, Xianjun Yu, Si Shi
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 9, Pp 1982-1995 (2023)
Abstract Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a critical role in the maintenance of cellular activities. Recently, increasing evidence has ind
Externí odkaz:
https://doaj.org/article/32d7a58d303745909adaa86742b6aae6
Autor:
Jialin Li, Si Shi, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Hang Xu, Miaoyan Wei, Bo Zhang, Jin Xu, Wei Wang, Xianjun Yu
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Radical surgical resection offers the only potential cure. There is increasing agreement that radical antegrade modular pancreatosplenectomy (RAMPS) may be
Externí odkaz:
https://doaj.org/article/b65320f33db541288534c219377a4434
Autor:
Si Shi, Huijie Gu, Jinyuan Xu, Wan Sun, Caiyin Liu, Tong Zhu, Juan Wang, Furong Gao, Jieping Zhang, Qingjian Ou, Caixia Jin, Jingying Xu, Hao Chen, Jiao Li, Guotong Xu, Haibin Tian, Lixia Lu
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 5, Pp 898-909 (2023)
Abstract Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor b
Externí odkaz:
https://doaj.org/article/b1018ceee8ef43c4ba9752099f05ab02
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-26 (2023)
Abstract Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs modulate many biological processes that are crucia
Externí odkaz:
https://doaj.org/article/db53f3ba84e1419686cd720fbae08776
Autor:
Rong Tang, Zifeng Zhang, Jin Xu, Wei Wang, Qingcai Meng, Yuan Liu, Qiong Du, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1689-1704 (2024)
Background: Mounting evidence underscores the importance of cell communication within the tumor microenvironment, which is pivotal in tumor proliferation, invasion, and metastasis. Exosomes play a crucial role in cell-to-cell communication. Although
Externí odkaz:
https://doaj.org/article/a7c01f957d71404990cf4a4033cc6d8f