Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Si Nga Sou"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Deactivated Cas9 fused to transactivation domains can be used to control gene expression, however its presence can prevent rapid switching between different regulatory states. Here the authors generate conditionally degradable dCas9 and Cpf1 proteins
Externí odkaz:
https://doaj.org/article/139a8430e48d45c080b0de7895062ab0
Autor:
Si Nga Sou, Claire L. Harris, Rebecca Williams, Dorota Kozub, Fabio Zurlo, Yash D. Patel, Praveen Kallamvalli Illam Sankaran, Olalekan Daramola, Adam Brown, David C. James, Diane Hatton, Sarah Dunn, Suzanne J. Gibson
Publikováno v:
Biotechnology Progress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088b3dd34516a35eafaed5112c57e28d
https://doi.org/10.1002/btpr.3348
https://doi.org/10.1002/btpr.3348
Autor:
null Si Nga Sou, null Claire L. Harris, null Rebecca Williams, null Dorota Kozub, null Fabio Zurlo, null Yash D. Patel, null Praveen Kallamvalli Illam Sankaran, null Olalekan Daramola, null Adam Brown, null David C. James, null Diane Hatton, null Sarah Dunn, null Suzanne J. Gibson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87d29bf240e49b9c51076a47aae9a15a
https://doi.org/10.1002/btpr.3348/v2/response1
https://doi.org/10.1002/btpr.3348/v2/response1
Autor:
Mike Jenns, Katie Willis, Fabio Zurlo, Rajesh K Mistry, Si Nga Sou, Diane Hatton, Emma J. Kelsall, Suzanne J. Gibson, Harriet Barker
Publikováno v:
Biotechnology and Bioengineering
The manufacture of bispecific antibodies by Chinese hamster ovary (CHO) cells is often hindered by lower product yields compared to monoclonal antibodies. Recently, reactive oxygen species have been shown to negatively impact antibody production. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca17e5608ddfa67f14ed69a9fe9d71d
https://doi.org/10.1002/bit.27744
https://doi.org/10.1002/bit.27744
Autor:
Kenneth Lee, Alison Mason, Sarantos Kyriakopoulos, Karen M. Polizzi, Cleo Kontoravdi, Christopher A. Sellick, Si Nga Sou
Publikováno v:
Biotechnology and Bioengineering. 112:1165-1176
The application of mild hypothermic conditions to cell culture is a routine industrial practice used to improve recombinant protein production. However, a thorough understanding of the regulation of dynamic cellular processes at lower temperatures is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39b28854f991cd0a4164a7a39c23002
https://doi.org/10.1002/bit.25524
https://doi.org/10.1002/bit.25524
Publikováno v:
Advances in Bioscience and Biotechnology. :1013-1019
Three transfection reagents, Lipofectamine® 2000, TransIT-PRO® and linear 25 kDa polyethylenimine were evaluated for transient expression of enhanced green fluorescent protein in Chinese hamster ovary cells. TransIT-PRO® was found to be more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e04c955cbfbfd9b86b05b127a499e8ef
https://doi.org/10.4236/abb.2013.412135
https://doi.org/10.4236/abb.2013.412135
Autor:
Si Nga, Sou, Philip M, Jedrzejewski, Ken, Lee, Christopher, Sellick, Karen M, Polizzi, Cleo, Kontoravdi
Publikováno v:
Biotechnology and Bioengineering
Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (q mAb) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc‐glycosylation and the mechanism behind changes in the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f06552ac70c9c947d6c2cbdd001b47f0
https://pubmed.ncbi.nlm.nih.gov/27869292
https://pubmed.ncbi.nlm.nih.gov/27869292
Publikováno v:
Biochemical and Biophysical Research Communications. 420:473-478
ER stress is activated in a number of important diseases such as diabetes, cancer, and neurodegeneration, but the molecular interactions governing the response are still being elucidated. In the absence of stress, protein complexes exist between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdf843f440da7eefa3a96a9f34be598
https://doi.org/10.1016/j.bbrc.2012.03.030
https://doi.org/10.1016/j.bbrc.2012.03.030
Autor:
Si Nga, Sou, Christopher, Sellick, Ken, Lee, Alison, Mason, Sarantos, Kyriakopoulos, Karen M, Polizzi, Cleo, Kontoravdi
Publikováno v:
Biotechnology and bioengineering. 112(6)
The application of mild hypothermic conditions to cell culture is a routine industrial practice used to improve recombinant protein production. However, a thorough understanding of the regulation of dynamic cellular processes at lower temperatures is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3677366bd6da42415a50f38fe9b4ff67
https://pubmed.ncbi.nlm.nih.gov/25545631
https://pubmed.ncbi.nlm.nih.gov/25545631
Autor:
Kealan Exley, Karen M. Polizzi, Sarantos Kyriakopoulos, Cleo Kontoravdi, Si Nga Sou, Ioscani Jimenez del Val, Philip M. Jedrzejewski
Publikováno v:
Glycosylation
© 2012 Kontoravdi et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reprodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e0f805c6065462aa2c6187b6d484d5
http://www.intechopen.com/articles/show/title/application-of-quality-by-design-paradigm-to-the-manufacture-of-protein-therapeutics
http://www.intechopen.com/articles/show/title/application-of-quality-by-design-paradigm-to-the-manufacture-of-protein-therapeutics