Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Si H. Yang"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 62:1-23
Objectives In rats with diabetes mellitus induced by alloxan (DMIA) or streptozocin (DMIS), changes in the cytochrome P450 (CYP) isozymes in the liver, lung, kidney, intestine, brain, and testis have been reported based on Western blot analysis, Nort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a012032f51fb9beb8a16500f65ec193
https://doi.org/10.1211/jpp.62.01.0001
https://doi.org/10.1211/jpp.62.01.0001
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:406-413
It has been reported that ondansetron is primarily metabolized via hepatic CYP2D and 3A1/2 in male Sprague-Dawley rats, and CYP2D1 and 3A2 are male dominant and male specific isozymes, respectively, in rats. Thus, it could be expected that the pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30684c7ee5626bad00680ead96cf4da
https://doi.org/10.1002/bdd.627
https://doi.org/10.1002/bdd.627
Publikováno v:
European Journal of Pharmaceutical Sciences. 25:337-345
Effects of diabetes mellitus induced by streptozotocin (DMIS) on the pharmacokinetics of DA-7867 were investigated after i.v. and oral administration (10mg/kg) to control Sprague-Dawley rats and DMIS rats (at 7th and 29th days after administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3edbf50891b24b9131e5c91a3c290ca
https://doi.org/10.1016/j.ejps.2005.03.009
https://doi.org/10.1016/j.ejps.2005.03.009
Publikováno v:
Archives of pharmacal research. 34(10)
Docetaxel is a P-glycoprotein (P-gp) substrate and metabolized via cytochrome P450 (CYP) 3A subfamily in rats. Morin is an inhibitor of both CYPs and P-gp. Hence, the effects of morin on the intravenous and oral pharmacokinetics of docetaxel were inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4d733a0d14731d12b346d30bb01ecc
https://pubmed.ncbi.nlm.nih.gov/22076773
https://pubmed.ncbi.nlm.nih.gov/22076773
Publikováno v:
Biopharmaceuticsdrug disposition. 31(7)
It has been reported that both nicardipine and lovastatin are substrates of both the cytochrome P450 (CYP) 3A subfamily and P-glycoprotein (P-gp), and P-gp transport is unlikely to be a significant factor. Thus, the effects of oral lovastatin on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aff7f06fb402b855b7911fbb6591388
https://pubmed.ncbi.nlm.nih.gov/20824619
https://pubmed.ncbi.nlm.nih.gov/20824619
Autor:
Myung Gyoon Lee, Si H. Yang
Publikováno v:
Biopharmaceuticsdrug disposition. 29(7)
The pharmacokinetic parameters of ondansetron were evaluated after its intravenous (at doses of 1, 4, 8 and 20 mg/kg) and oral (4, 8 and 20 mg/kg) administration to rats. The gastric, intestinal and hepatic first-pass effects of ondansetron were also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0641db61b5bf07cb5f7d502d83643a
https://pubmed.ncbi.nlm.nih.gov/18697186
https://pubmed.ncbi.nlm.nih.gov/18697186
Autor:
Si H. Yang, Myung Gyoon Lee
Publikováno v:
The Journal of pharmacy and pharmacology. 60(7)
The types of hepatic microsomal cytochrome P450 (CYP) isozymes responsible for the in-vivo metabolism of ondansetron in rats have not been reported. In this study, ondansetron at a dose of 8 mg kg−1 was administered intravenously to rats pretreated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec78299d4efc8b3a92da18fb6e6164ce
https://pubmed.ncbi.nlm.nih.gov/18549671
https://pubmed.ncbi.nlm.nih.gov/18549671
Publikováno v:
The Journal of pharmacy and pharmacology. 59(7)
DA-7218 (a prodrug of DA-7157), a new oxazolidinone, was hydrolysed via phosphatase to form its active metabolite, DA-7157, in rats. The pharmacokinetic parameters of DA-7218 and DA-7157 were evaluated after intravenous (5, 10 and 20 mg kg−1) and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4998ce016b6e3a7e3433c4e0febbf51c
https://pubmed.ncbi.nlm.nih.gov/17637190
https://pubmed.ncbi.nlm.nih.gov/17637190
Autor:
Si H. Yang, Myung Gyoon Lee
Publikováno v:
International journal of pharmaceutics. 332(1-2)
Purpose. To evaluate the pharmacokinetics of telithromycin after intravenous and oral administration and to find the reason for incomplete F value (first pass- effect) after intravenous, intraportal, intragastric, and intraduodenal administration to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e4279bd5523aaf273ee555e0202296
https://pubmed.ncbi.nlm.nih.gov/17157458
https://pubmed.ncbi.nlm.nih.gov/17157458
Publikováno v:
Biopharmaceuticsdrug disposition. 27(1)
Gender differences in the pharmacokinetics of DA-6034 were evaluated after intravenous and oral administration at a dose of 50 mg/kg to male and female Sprague–Dawley rats. After intravenous administration to male rats, although the total area unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4d7b45cd714369e07a90024ef9076f
https://pubmed.ncbi.nlm.nih.gov/16302288
https://pubmed.ncbi.nlm.nih.gov/16302288