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Publikováno v:
International Journal of Pharmaceutics. 84:273-278
The pharmacokinetic parameters of rHuIFN-α A, such as t 1 2 (53.7–85.3 min), MRT (29.5–42.4 min), Vss (107–163 ml kg−1) and CL (3.65–4.69 ml min−1 kg−1) were found to be dose-independent after intravenous administration to rabbits usin