Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Si Cheng Liu"'
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 988-993 (2023)
Externí odkaz:
https://doaj.org/article/5e7fb224ae20488b976cdd1b541b1577
Autor:
Tao Guo, Guo-Qiao Chen, Xu-Fan Li, Meng Wang, Kun-Ming Liu, Xiao-Ying Yang, Si-Cheng Liu, Yi-Li Feng, Peng-Yuan Liu, Hui Lin, An-Yong Xie
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-24 (2023)
Abstract Background Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to elucidate how IGH is
Externí odkaz:
https://doaj.org/article/97725a99358d48d69443ef1cd2c65196
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The failure of endogenous repair is the main feature of neurological diseases that cannot recover the damaged tissue and the resulting dysfunction. Currently, the range of treatment options for neurological diseases is limited, and the approved drugs
Externí odkaz:
https://doaj.org/article/ed1ed0bd43494bbf8f37a1966c8e375a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102072- (2023)
Paired SpCas9 nickases (SpCas9n) are an effective strategy to reduce off-target effect in genome editing. However, this approach is not efficient with 3′-overhanging ends, limiting its applications. In order to expand the utility of paired SpCas9n
Externí odkaz:
https://doaj.org/article/8c880b1b54f84caeabaf083b01abb9ed
Autor:
Si-Cheng Liu, Yi-Li Feng, Xiu-Na Sun, Ruo-Dan Chen, Qian Liu, Jing-Jing Xiao, Jin-Na Zhang, Zhi-Cheng Huang, Ji-Feng Xiang, Guo-Qiao Chen, Yi Yang, Chao Lou, Hao-Dan Li, Zhen Cai, Shi-Ming Xu, Hui Lin, An-Yong Xie
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-32 (2022)
Abstract Background Due to post-cleavage residence of the Cas9-sgRNA complex at its target, Cas9-induced DNA double-strand breaks (DSBs) have to be exposed to engage DSB repair pathways. Target interaction of Cas9-sgRNA determines its target binding
Externí odkaz:
https://doaj.org/article/3baeafdd016e47d9820a0acff3a8a5a0
Autor:
Yi-Li Feng, Qian Liu, Ruo-Dan Chen, Si-Cheng Liu, Zhi-Cheng Huang, Kun-Ming Liu, Xiao-Ying Yang, An-Yong Xie
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
It remains unclear how BRCA1-associated mutational sigantures are generated in cancer. Here, the authors develop nCas9-based approaches to uncover that aberrant repair of one-ended DSBs converted from DNA nicks by replication, not that of two-ended D
Externí odkaz:
https://doaj.org/article/d810812f909745a59edd229ffcf2ef63
Publikováno v:
Kemija u Industriji, Vol 70, Iss 3-4, Pp 121-127 (2021)
A ZSM-5 molecular sieve composite with a wide pore prepared by the solid phase in-situ synthesis method and fluid catalytic cracking, and an FCC catalyst additive prepared by the same ZSM-5 molecular sieve for increasing the amount of light olefin yi
Externí odkaz:
https://doaj.org/article/6e40734889ad4aac8b52b7ed3d2326c0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Objectives: The purpose of this study is to investigate the effects of transplantation of microencapsulated neural stem cells (MC-NSCs), which downregulate the P2 × 4 receptor (P2 × 4R) overexpression and relieve neuropathic pain (NPP).Methods: Neu
Externí odkaz:
https://doaj.org/article/43da867738574e7fb88ccb37db9982c3
Publikováno v:
Kemija u Industriji, Vol 68, Iss 5-6, Pp 201-208 (2019)
An adsorbent prepared from fluid catalytic cracking (FCC) spent catalyst fines and diatomite, and its adsorption of Cu2+, Zn2+, and Ni2+ ions were investigated. The adsorbent was characterized by XRD, SEM, and N2 adsorption-desorption techniques. The
Externí odkaz:
https://doaj.org/article/97a030d07c724d29abd5d94fbee28780
Autor:
Yi-Li Feng, Si-Cheng Liu, Ruo-Dan Chen, Xiu-Na Sun, Jing-Jing Xiao, Ji-Feng Xiang, An-Yong Xie
Publikováno v:
Nucleic Acids Research. 51:2740-2758
In CRISPR/Cas9 genome editing, the tight and persistent target binding of Cas9 provides an opportunity for efficient genetic and epigenetic modification on genome. In particular, technologies based on catalytically dead Cas9 (dCas9) have been develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2f9366261dac71b4c6ff7021e9a1d2c
https://doi.org/10.1093/nar/gkad116
https://doi.org/10.1093/nar/gkad116