Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Si‑Min Zhang"'
Autor:
Siqian Gong, Xueyao Han, Meng Li, Xiaoling Cai, Wei Liu, Yingying Luo, Si-min Zhang, Lingli Zhou, Yumin Ma, Xiuting Huang, Yufeng Li, Xianghai Zhou, Yu Zhu, Qiuping Wang, Ling Chen, Qian Ren, Ping Zhang, Linong Ji
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
ObjectivesPPARγ variants cause lipodystrophy, insulin resistance, and diabetes. This study aimed to determine the relationship between PPARγ genotypes and phenotypes and to explore the pathogenesis of diabetes beyond this relationship.MethodsPPARγ
Externí odkaz:
https://doaj.org/article/25200fe0b3d34a54b36336569d4c4ddc
Autor:
Chuan-Yuan Wei, Lu Wang, Meng-Xuan Zhu, Xin-Yi Deng, Dao-He Wang, Si-Min Zhang, Jiang-Hui Ying, Xin Yuan, Qiang Wang, Tian-Fan Xuan, An-Qi He, Fa-Zhi Qi, Jian-Ying Gu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-13 (2019)
Abstract Background There is growing evidence that tripartite motif-containing protein 44 (TRIM44) plays crucial role in tumor development. However, the underlying mechanism of this deubiquitinating enzyme remains unclear. Methods Large clinical samp
Externí odkaz:
https://doaj.org/article/cc5f49da77cf48b99a12ba527f6e1820
Autor:
Hong-Min Zhu, Si-Min Zhang, Cong Yao, Meng-Qing Luo, Hui-Jing Ma, Tao Lei, Chun-Hui Yuan, Ge-Fei Wu, Jia-Sheng Hu, Chun-Quan Cai, Zhi-Sheng Liu
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
Background: Acute necrotizing encephalopathy of childhood (ANE) is a rare but rapidly progressing encephalopathy. Importantly, the exact pathogenesis and evidence-based treatment is scarce. Thus, we aimed to identify the clinical, imaging, and therap
Externí odkaz:
https://doaj.org/article/8296ee694e89426d8f29a61331019cb6
Autor:
Nicholas C. K. Valerie, Kumar Sanjiv, Oliver Mortusewicz, Si Min Zhang, Seher Alam, Maria J. Pires, Hannah Stigsdotter, Azita Rasti, Marie-France Langelier, Daniel Rehling, Adam Throup, Oryn Purewal-Sidhu, Matthieu Desroses, Jacob Onireti, Prasad Wakchaure, Ingrid Almlöf, Johan Boström, Luka Bevc, Giorgia Benzi, Pål Stenmark, John M. Pascal, Thomas Helleday, Brent D. G. Page, Mikael Altun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation o
Externí odkaz:
https://doaj.org/article/da8b368cca654c56b35ce8a1e37b2285
Autor:
Li-Hua Tian, Xue-Yao Han, Xiu-Ting Huang, Si-Min Zhang, Si-Qian Gong, Yu-Min Ma, Xiao-Ling Cai, Ling-Li Zhou, Ying-Ying Luo, Meng Li, Wei Liu, Xiu-Ying Zhang, Qian Ren, Yu Zhu, Xiang-Hai Zhou, Rui Zhang, Ling Chen, Xue-Ying Gao, Yan Liu, Fang Zhang, Li-Nong Ji
Publikováno v:
Chinese Medical Journal, Vol 131, Iss 9, Pp 1117-1119 (2018)
Externí odkaz:
https://doaj.org/article/e02588e6cfd3499da0ac0af46ab19d24
Autor:
Jun-Zhi Wen, Jian-You Liao, Ling-Ling Zheng, Hui Xu, Jian-Hua Yang, Dao-Gang Guan, Si-Min Zhang, Hui Zhou, Liang-Hu Qu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88179 (2014)
MicroRNAs (miRNAs) are important regulators of many cellular processes and exist in a wide range of eukaryotes. High-throughput sequencing is a mainstream method of miRNA identification through which it is possible to obtain the complete small RNA pr
Externí odkaz:
https://doaj.org/article/0d5835e4708b487f80e136ec431181b2
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Hao-dong Sun, Bei-bei Du, Ya-zhang Wu, Hai-lan Wang, Xia-yu Zhang, Juan Wang, Si-min Zhang, Shan-shan Wei, Tao Yu
Publikováno v:
Journal of Central South University. 28:3907-3934
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d7efcc5c5eb70b6a438de601ee61f0
https://doi.org/10.1007/s11771-021-4888-2
https://doi.org/10.1007/s11771-021-4888-2
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Maurice Michel, Petra Marttila, Miriam Yagüe-Capilla, Henri Colyn Bwanika, Huazhang Shu, Rajagopal Papagudi Vekatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Florian Ortis, Christopher Dirks, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Sterile alpha motif and histidine-aspartic acid domain containing protein-1 (SAMHD1) is a deoxynucleoside triphosphate (dNTP) triphosphohydrolase central to cellular nucleotide pool homeostasis. Recent literature has also demonstrated how SAMHD1 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18528c03f820b941db5dd13e66d5a66
https://doi.org/10.1101/2023.01.17.524275
https://doi.org/10.1101/2023.01.17.524275
