Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Siân Lax"'
Autor:
Graham McIlroy, Siân Lax, Charlotte Gaskell, Aimee Jackson, Malcolm Rhodes, Tania Seale, Sonia Fox, Lousie Hopkins, Jessica Okosun, Sally F. Barrington, Ingo Ringshausen, Alan G. Ramsay, Maria Calaminici, Kim Linton, Mark Bishton
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, b
Externí odkaz:
https://doaj.org/article/569fb28841214450b4923be543937b12
Autor:
Gideon M. Hirschfield, Katherine Arndtz, Amanda Kirkham, Yung-Yi Chen, Richard Fox, Anna Rowe, Jessica Douglas-Pugh, Douglas Thorburn, Eleanor Barnes, Guruprasad P. Aithal, Diana Hull, Khushpreet Bhandal, Kathryn Olsen, Paul Woodward, Siân Lax, Philip Newsome, David J. Smith, Antero Kallio, David H. Adams, Victoria Homer, Chris J. Weston
Publikováno v:
Hepatology Communications, Vol 8, Iss 5 (2024)
Background:. Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We evaluated the
Externí odkaz:
https://doaj.org/article/1b222fe6ac3c4e409c92ca04f98f474a
Autor:
Divyalakshmi Bhaskaran, Joshua Savage, Amit Patel, Fiona Collinson, Rhys Mant, Florien Boele, Lucy Brazil, Sara Meade, Peter Buckle, Siân Lax, Lucinda Billingham, Susan C. Short
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Glioblastoma (GBM) is the most common adult malignant brain tumour, with an incidence of 5 per 100,000 per year in England. Patients with tumours showing O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation represent
Externí odkaz:
https://doaj.org/article/eab0ef4f27614cabaf65f9eab32b4134
Autor:
Rahul Y. Mahida, Siân Lax, Christopher R. Bassford, Aaron Scott, Dhruv Parekh, Rowan S. Hardy, Babu Naidu, Michael A. Matthay, Paul M. Stewart, Mark C. Cooper, Gavin D. Perkins, David R. Thickett
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a devastating pulmonary inflammatory disorder, commonly precipitated by sepsis. Glucocorticoids are immunomodulatory steroids that can suppress inflammation. Their anti-inflammatory properties w
Externí odkaz:
https://doaj.org/article/79837288f2f145448fc78353241ec42d
Autor:
Julie Rayes, Siân Lax, Surasak Wichaiyo, Stephanie K. Watson, Ying Di, Stephanie Lombard, Beata Grygielska, Stuart W. Smith, Kassiani Skordilis, Steve P. Watson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiti
Externí odkaz:
https://doaj.org/article/b4f263bdafe34009bf6c603e5a0f07a4
Autor:
Julie Rayes, Soumaya Jadoui, Siân Lax, Angèle Gros, Surasak Wichaiyo, Véronique Ollivier, Cécile V. Denis, Jerry Ware, Bernhard Nieswandt, Martine Jandrot-Perrus, Steve P. Watson, Benoît Ho-Tin-Noé
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Externí odkaz:
https://doaj.org/article/2963d4ec003c441ea7377628b049bf83
Autor:
Benoît Ho-Tin-Noé, Steve P. Watson, Cécile V. Denis, Angèle Gros, Martine Jandrot-Perrus, Julie Rayes, Véronique Ollivier, Soumaya Jadoui, Jerry Ware, Surasak Wichaiyo, Siân Lax, Bernhard Nieswandt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc744aeb3eafcfba6ef5a549af51529
https://europepmc.org/articles/PMC6058802/
https://europepmc.org/articles/PMC6058802/
Autor:
Siân, Lax, Julie, Rayes, Surasak, Wichaiyo, Elizabeth J, Haining, Kate, Lowe, Beata, Grygielska, Ryan, Laloo, Per, Flodby, Zea, Borok, Edward D, Crandall, David R, Thickett, Steve P, Watson
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology
There is no therapeutic intervention proven to prevent acute respiratory distress syndrome (ARDS). Novel mechanistic insights into the pathophysiology of ARDS are therefore required. Platelets are implicated in regulating many of the pathogenic proce
Publikováno v:
BMJ Open Respiratory Research
Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct consequence of an in vivo murine model of acute lung injury. Here, we report daily changes in arterial oxygen saturation and other cardiopulmonary parameters
Autor:
Nicole, Simonavicius, Matthew, Ashenden, Antoinette, van Weverwijk, Siân, Lax, David L, Huso, Christopher D, Buckley, Ivo J, Huijbers, Ivo J, Huijber, Helen, Yarwood, Clare M, Isacke
Publikováno v:
Blood. 120(7)
Blood vessel networks form in a 2-step process of sprouting angiogenesis followed by selective branch regression and stabilization of remaining vessels. Pericytes are known to function in stabilizing blood vessels, but their role in vascular sproutin