Zobrazeno 1 - 10
of 632
pro vyhledávání: '"Si, Shi"'
Autor:
Jun Xu, Zhongyue Huang, Si Shi, Jiangni Xia, Guangnan Chen, Kaifeng Zhou, Yiming Zhang, Chong Bian, Yuqin Shen, Xiaofan Yin, Lixia Lu, Huijie Gu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-14 (2024)
Abstract An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered the basic pathogenesis of osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in the differentiation of
Externí odkaz:
https://doaj.org/article/63fc4aadd1d14fcc922b7ff55bf27cbc
Autor:
Yao Yu, Yu Shang, Si Shi, Yaowu He, Wenchao Shi, Menghan Wang, Qi Wang, Dandan Xu, Ce Shi, Hong Chen
Publikováno v:
Hereditas, Vol 161, Iss 1, Pp 1-16 (2024)
Abstract Background Small cell lung carcinoma (SCLC) is characterized by -poor prognosis, -high predilection for -metastasis, -proliferation, and -absence of newer therapeutic options. Elucidation of newer pathways characterizing the disease may allo
Externí odkaz:
https://doaj.org/article/d9a4d6418055438982679eeea15a212f
Autor:
Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu, Xianjun Yu
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy remains the standard first-line treatment for pancreatic adenocarcinoma, but with limited efficacy. We aimed to explore the feasibility of adding the PARP inhibitor fuzuloparib to mFOLFIRINOX in the locally advanced/m
Externí odkaz:
https://doaj.org/article/cef3d052c08f444f99a82d9527d12961
Autor:
Rong Tang, Zifeng Zhang, Jin Xu, Wei Wang, Qingcai Meng, Yuan Liu, Qiong Du, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1689-1704 (2024)
Background: Mounting evidence underscores the importance of cell communication within the tumor microenvironment, which is pivotal in tumor proliferation, invasion, and metastasis. Exosomes play a crucial role in cell-to-cell communication. Although
Externí odkaz:
https://doaj.org/article/a7c01f957d71404990cf4a4033cc6d8f
Autor:
Mingming Xiao, Jing Yang, Mingwei Dong, Xiaoqi Mao, Haoqi Pan, Yalan Lei, Xuhui Tong, Xiaoning Yu, Xianjun Yu, Si Shi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-16 (2024)
Abstract Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of pancreatic cancer patients have inherent resistance or develop tolerance t
Externí odkaz:
https://doaj.org/article/67c593f6585e478c9e65fdc330dcf273
Autor:
Xiaoqi Mao, Jin Xu, Mingming Xiao, Chen Liang, Jie Hua, Jiang Liu, Wei Wang, Xianjun Yu, Qingcai Meng, Si Shi
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103200- (2024)
Currently, chemotherapy remains occupying a pivotal place in the treatment of pancreatic ductal adenocarcinoma (PDAC). Nonetheless, the emergence of drug resistance in recent years has limited the clinical efficacy of chemotherapeutic agents, especia
Externí odkaz:
https://doaj.org/article/52405a8f56004b489abd69e2f4ca4e76
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Schizophrenia significantly impacts cognitive and behavioral functions and is primarily treated with second-generation antipsychotics (SGAs) such as olanzapine. Despite their efficacy, these drugs are linked to serious metabolic side effects which ca
Externí odkaz:
https://doaj.org/article/88f6096983c64c97aa3a3f608213a448
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and its molecular mechanisms are unclear. Nucleolar and spindle-associated protein 1 (NUSAP1), an indispensable mitotic regulator, has been reported to be involved in t
Externí odkaz:
https://doaj.org/article/9e6a49fe37a546c680d3a23bf1b69e3f
Autor:
Heng Zhu, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Si Shi
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105098- (2024)
Summary: Background: The widespread involvement of tumor-infiltrating B cells highlights their potential role in tumor behavior. However, B cell heterogeneity in PDAC remains unexplored. Studying TIL-Bs in PDAC aims to identify new treatment strategi
Externí odkaz:
https://doaj.org/article/1f49f20bec0b41ff810d3b710542204e
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-29 (2023)
Abstract Research into the potential benefits of artificial intelligence for comprehending the intricate biology of cancer has grown as a result of the widespread use of deep learning and machine learning in the healthcare sector and the availability
Externí odkaz:
https://doaj.org/article/cfbb1fe0bbb44dd3badf19fc5a91b729