PP6.3 - Safety and potential impact of auranofin on the viral reservoir in HIV positive individuals under mega-ART

Autor: Diaz, R.S., Giron, L.B., Galinskas, J., Dias, D., Hunter, J., Tenore, S., Gosuen, G., Samer, S., Umaki, M., Shoaib Arif, M., Nutini, M., Luca Shytaj, I., Lucic, B., Lusic, M., Janini, M., Sucupira, M.C., Savarino, A.

Publikováno v: In Journal of Virus Eradication December 2017 3 Supplement 5:43-43

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The FDA-Approved Drug Cobicistat Synergizes with Remdesivir to Inhibit SARS-CoV-2 Replication in Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

Autor: Iart Luca Shytaj, Mohamed Fares, Lara Gallucci, Bojana Lucic, Mahmoud M. Tolba, Liv Zimmermann, Julia M. Adler, Na Xing, Judith Bushe, Achim D. Gruber, Ina Ambiel, Ahmed Taha Ayoub, Mirko Cortese, Christopher J. Neufeldt, Bettina Stolp, Mohamed Hossam Sobhy, Moustafa Fathy, Min Zhao, Vibor Laketa, Ricardo Sobhie Diaz, Richard E. Sutton, Petr Chlanda, Steeve Boulant, Ralf Bartenschlager, Megan L. Stanifer, Oliver T. Fackler, Jakob Trimpert, Andrea Savarino, Marina Lusic

Publikováno v: Shytaj, I L, Fares, M, Gallucci, L, Lucic, B, Tolba, M M, Zimmermann, L, Adler, J M, Xing, N, Bushe, J, Gruber, A D, Ambiel, I, Taha Ayoub, A, Cortese, M, Neufeldt, C J, Stolp, B, Sobhy, M H, Fathy, M, Zhao, M, Laketa, V, Diaz, R S, Sutton, R E, Chlanda, P, Boulant, S, Bartenschlager, R, Stanifer, M L, Fackler, O T, Trimpert, J, Savarino, A & Lusic, M 2022, ' The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters ', mBio, vol. 13, no. 2, e03705-21 . https://doi.org/10.1128/mbio.03705-21

The lack of effective antiviral treatments against SARS-CoV-2 is a significant limitation in the fight against the COVID-19 pandemic. Single-drug regimens have so far yielded limited results, indicating that combinations of antivirals might be requir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb360832c773978411f426f2ad48a690
https://hdl.handle.net/11591/486754