Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Shyrie Edmonson"'
Autor:
Katherine A. High, Virginia Haurigot, F Mingozzi, Fatima Bosch, Eduard Ayuso, Xavier M. Anguela, L Africa, Shangzhen Zhou, Shyrie Edmonson, J F Wright, Joel Montane, Xavier León
Publikováno v:
Gene Therapy. 17:503-510
The purity of adeno-associated virus (AAV) vector preparations has important implications for both safety and efficacy of clinical gene transfer. Early-stage screening of candidates for AAV-based therapeutics ideally requires a purification method th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba47a499b6908438b50a427069e9b296
https://doi.org/10.1038/gt.2009.157
https://doi.org/10.1038/gt.2009.157
Publikováno v:
Molecular Therapy. 16(12):1960-1967
We set out to analyze the fundamental biological differences between AAV2 and AAV8 that may contribute to their different performances in vivo. High-throughput protein interaction screens were used to identify binding partners for each serotype. Of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddc995b9ea0e5f6ab1671956635a7d2
Autor:
Shyrie Edmonson, Denise E. Sabatino, Katherine A. High, Hojun Li, Federico Mingozzi, Samuel L. Murphy, Daniel J. Hui
Publikováno v:
Journal of Medical Virology. 81:65-74
Humoral immune responses occur following exposure to Adeno-associated virus (AAV) or AAV vectors. Many studies characterized antibody responses to AAV, but human IgG subclass responses to AAV have not been previously described. In this study, IgG sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02baa7b7d3a60e84f00638a9c8744688
https://doi.org/10.1002/jmv.21360
https://doi.org/10.1002/jmv.21360
Autor:
Denise E. Sabatino, Cesare Campagnoli, Tippi C. MacKenzie, Yi-Lin Liu, William H. Peranteau, Shyrie Edmonson, Alan W. Flake, Katherine A. High
Publikováno v:
Molecular Therapy. 15:1677-1685
The major complication associated with protein replacement therapy currently used in the treatment of hemophilia B (HB) is the development of antibodies to the infused human Factor IX (hF.IX). We hypothesized that vector-mediated expression of hF.IX,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06912a5a6f94feaa0ffc3bbe8acbf39
https://doi.org/10.1038/sj.mt.6300219
https://doi.org/10.1038/sj.mt.6300219
Autor:
Samuel L. Murphy, Katherine A. High, Wynetta Giles-Davis, Hua Li, Shyrie Edmonson, Hildegund C.J. Ertl, Marcio O. Lasaro, Yan Li, Zhiquan Xiang
Publikováno v:
Molecular Therapy. 15:792-800
The goal of these studies was to test whether adeno-associated virus (AAV) capsid-specific CD8(+) T cells cause loss of hepatic AAV-mediated gene expression in experimental animals. Mice immunized with adenoviral vectors expressing AAV capsid or with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4cc5141549ea98205f579ea5c9b62d
https://doi.org/10.1038/sj.mt.6300090
https://doi.org/10.1038/sj.mt.6300090
Autor:
Yi Zhang, Alexander Schlachterman, Jianxiang Zou, Yi-Lin Liu, Valder R. Arruda, Joerg Schuettrumpf, Shyrie Edmonson, Weidong Xiao
Publikováno v:
Molecular Therapy. 13:88-97
Identifying factors that influence gene transfer efficacy is critical for a successful gene-based clinical study. Here we demonstrate that in vivo AAV-2-mediated gene transfer is efficiently inhibited by unfractionated heparin, but not by a heparin p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856a6b9f6787601ad88712a348e171cc
https://doi.org/10.1016/j.ymthe.2005.08.004
https://doi.org/10.1016/j.ymthe.2005.08.004
Autor:
Marc Pleimes, Shyrie Edmonson, Valder R. Arruda, Elina Armstrong, Denise E. Sabatino, Roland W. Herzog, Julie C. Fitzgerald, Yi-Lin Liu, Joerg Schuettrumpf, Katherine A. High
Publikováno v:
Blood. 104:2767-2774
Animal models have been critical to the development of novel therapeutics in hemophilia. A deficiency of current murine models of hemophilia B is that they are all due to gene deletions, a type of mutation that is relatively rare in the human hemophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0557679fba6ebd1174dfe27dbe082120
https://doi.org/10.1182/blood-2004-03-1028
https://doi.org/10.1182/blood-2004-03-1028
Autor:
John J.P. Kastelein, Erik S.G. Stroes, Katherine A. High, Etiena Basner-Tschakarjan, Natalie A. Hutnick, Nicole C. Hasbrouck, Federico Mingozzi, Daniel J. Hui, Shyrie Edmonson, Janneke J. Meulenberg, Michael R. Betts
Publikováno v:
Blood, 114(10), 2077-2086. American Society of Hematology
In a clinical trial for adeno-associated virus serotype 1 (AAV-1)–mediated gene transfer to muscle for lipoprotein lipase (LPL) deficiency, 1 subject from the high-dose cohort experienced a transient increase in the muscle enzyme creatine phosphoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad24a6f6b59148987b7387edb309fa6f
https://pure.amc.nl/en/publications/aav1mediated-gene-transfer-to-skeletal-muscle-in-humans-results-in-dosedependent-activation-of-capsidspecific-t-cells(cccc3c39-ec78-468c-acf2-a0ef66b68c34).html
https://pure.amc.nl/en/publications/aav1mediated-gene-transfer-to-skeletal-muscle-in-humans-results-in-dosedependent-activation-of-capsidspecific-t-cells(cccc3c39-ec78-468c-acf2-a0ef66b68c34).html
Autor:
Daniel J. Hui, Glenn F. Pierce, Shangzhen Zhou, J. Fraser Wright, Federico Mingozzi, Denise E. Sabatino, Haiyan Jiang, Shyrie Edmonson, Nicole C. Hasbrouck, Katherine A. High, Etiena Basner-Tschakarjan, Valder R. Arruda
Publikováno v:
Blood. 110(7)
Adeno-associated virus (AAV)–mediated gene transfer of factor IX (F.IX) to the liver results in long-term expression of transgene in experimental animals, but only short-term expression in humans. Loss of F.IX expression is likely due to a cytotoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc282292e28179686ee84b589b432bb7
https://pubmed.ncbi.nlm.nih.gov/17609423
https://pubmed.ncbi.nlm.nih.gov/17609423
Publikováno v:
Molecular Therapy. 13:S31-S32
Adeno-associated virus (AAV) vectors hold the potential to treat a variety of inherited and acquired human diseases. One of the confounding issues regarding the use of AAV in humans is the cellular immune response to the virus vector. While the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e0c87909d4ba1d8aa6a15ff8fde215
https://doi.org/10.1016/j.ymthe.2006.08.091
https://doi.org/10.1016/j.ymthe.2006.08.091