Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shyh Jen Shih"'
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 740:34-42
Radiation treatment or chemotherapy has been linked with a higher risk of secondary cancers such as therapy related Acute Myeloid Leukemia (tAML). Several of these cancers have been shown to be correlated to the introduction of double stranded breaks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73518130526c9d824331d1c54b4866b6
https://doi.org/10.1016/j.mrfmmm.2012.12.006
https://doi.org/10.1016/j.mrfmmm.2012.12.006
Autor:
Shyh Jen Shih, Manuel O. Diaz, Dawei Lin, Andrew T M Vaughan, Joseph Fass, Vincent Buffalo, Sheetal Singh
Publikováno v:
British Journal of Haematology. 159:50-57
Summary MLL rearrangements were analysed in the blood of a patient receiving chemotherapy for diffuse large B-cell lymphoma using inverse polymerase chain reaction targeting exon 12, parallel sequencing and a custom algorithm design. Of thirteen MLL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac3e030c186929236fc6a2d7cae05c
https://doi.org/10.1111/j.1365-2141.2012.09248.x
https://doi.org/10.1111/j.1365-2141.2012.09248.x
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 76:566-573
Purpose Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear. Here we investigated the effect of suberoylanilide hydrox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca597488eb4f4b75490b928075f1b77
https://doi.org/10.1016/j.ijrobp.2009.08.031
https://doi.org/10.1016/j.ijrobp.2009.08.031
Autor:
Allan Y. Chen, Shyh-Jen Shih, Liza N. Garriques, Mace L. Rothenberg, Michael Hsiao, Dennis P. Curran
Publikováno v:
Molecular Cancer Therapeutics. 4:317-324
The silatecan 7-tert-butyldimethylsilyl-10-hydroxy-camptothecin (DB-67) represents a new generation of camptothecin derivatives that exhibits a potent in vitro DNA topoisomerase I (TOP1)–mediated DNA-damaging activity, improved blood stability, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd502d9933ef1c6964bf24a61c15c2a
https://doi.org/10.1158/1535-7163.317.4.2
https://doi.org/10.1158/1535-7163.317.4.2
Publikováno v:
Critical Reviews in Oncology/Hematology. 50:111-119
Since its discovery more than a century ago, ionizing radiation has become a mainstay therapy for patients suffering from cancers. Currently, radiotherapy provides cure or palliative care for approximately one half of the cancer population. The antic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae6a68963082ddf71a681e3acdae66b
https://doi.org/10.1016/j.critrevonc.2003.09.005
https://doi.org/10.1016/j.critrevonc.2003.09.005
Publikováno v:
Genes, chromosomescancer. 51(5)
Radiation is a potent inducer of DNA damage leading to both random DNA loss and mutation. As part of a study focused on the mechanism whereby cells undergo loss of heterozygosity (LOH), a region of common LOH telomeric termination at 11q24 was observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bd6a3b892bacf3ccaf508ad9206ff8
https://pubmed.ncbi.nlm.nih.gov/22334386
https://pubmed.ncbi.nlm.nih.gov/22334386
Publikováno v:
Discovery medicine. 4(22)
Extract: Radiation has become a mainstay therapy and currently provides care for approximately one half of the cancer population since its discovery more than a century ago. However, the efficacy of radiotherapy is largely restricted by the radiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0d629030c273db6ae64e4528b4175b3
https://pubmed.ncbi.nlm.nih.gov/20704988
https://pubmed.ncbi.nlm.nih.gov/20704988
Autor:
Christine Bien, Shyh Jen Shih, To Uyen Do, Carol M. Bier-Laning, Manual O. Diaz, Nga Du, Andrew T M Vaughan, Sheetal Singh, Pamela M. Baker
Publikováno v:
Genes, chromosomescancer. 49(9)
The chromosome location, 11q21-23, is linked to loss of heterozygosity (LOH) in multiple tumors including those of breast, lung, and head and neck. To examine the process of LOH induction, the H292 cell line (human muco-epidermoid carcinoma) was irra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe2459fa45ce348f19612b6d9730eaa
https://pubmed.ncbi.nlm.nih.gov/20607707
https://pubmed.ncbi.nlm.nih.gov/20607707
Publikováno v:
Molecular pharmacology. 66(3)
DNA topoisomerase I (TOP1) mediates the induction of radiosensitization (RS) by camptothecin derivatives in mammalian cells. Many indolocarbazole (INDO) derivatives have been shown to induce TOP1-mediated DNA damage (T1DD). In the current study, we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::488aff9096f65dded98e8846a0f1c05d
https://pubmed.ncbi.nlm.nih.gov/15322247
https://pubmed.ncbi.nlm.nih.gov/15322247
Autor:
Sharon Grehan, Elizabeth Tse, John M. Taylor, Charles M. Allan, Shyh-Jen Shih, Cathal J. Moran
Publikováno v:
The Journal of biological chemistry. 275(41)
Two distal enhancers that specify apolipoprotein (apo) E gene expression in isolated macrophages and adipose tissue were identified in transgenic mice that were generated with constructs of the human apoE/C-I/C-I′/C-IV/C-II gene cluster. One of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54669c6cca2e2e4b22a0f2882924046
https://pubmed.ncbi.nlm.nih.gov/10893248
https://pubmed.ncbi.nlm.nih.gov/10893248