IL-4 Licenses B Cell Activation Through Cholesterol Synthesis.

Autor: Steach HR, York AG, Skadow MH, Chen S, Zhao J, Williams KJ, Zhou Q, Hsieh WY, Brewer JR, Qu R, Shyer JA, Harman C, Sefik E, Mowell WK, Bailis W, Cui C, Kluger Y, Bensinger SJ, Craft J, Flavell RA

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 15. Date of Electronic Publication: 2024 May 15.

Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors.

Autor: Castiglioni A; Genentech, South San Francisco, CA, USA., Yang Y; Genentech, South San Francisco, CA, USA., Williams K; Genentech, South San Francisco, CA, USA., Gogineni A; Genentech, South San Francisco, CA, USA., Lane RS; Genentech, South San Francisco, CA, USA., Wang AW; Genentech, South San Francisco, CA, USA., Shyer JA; Genentech, South San Francisco, CA, USA., Zhang Z; Genentech, South San Francisco, CA, USA., Mittman S; Genentech, South San Francisco, CA, USA., Gutierrez A; Genentech, South San Francisco, CA, USA., Astarita JL; Genentech, South San Francisco, CA, USA., Thai M; Genentech, South San Francisco, CA, USA., Hung J; Genentech, South San Francisco, CA, USA., Yang YA; Genentech, South San Francisco, CA, USA., Pourmohamad T; Genentech, South San Francisco, CA, USA., Himmels P; Genentech, South San Francisco, CA, USA., De Simone M; Genentech, South San Francisco, CA, USA., Elstrott J; Genentech, South San Francisco, CA, USA., Capietto AH; Genentech, South San Francisco, CA, USA., Cubas R; Genentech, South San Francisco, CA, USA., Modrusan Z; Genentech, South San Francisco, CA, USA., Sandoval W; Genentech, South San Francisco, CA, USA., Ziai J; Genentech, South San Francisco, CA, USA., Gould SE; Genentech, South San Francisco, CA, USA., Fu W; Genentech, South San Francisco, CA, USA., Wang Y; Genentech, South San Francisco, CA, USA., Koerber JT; Genentech, South San Francisco, CA, USA., Sanjabi S; Genentech, South San Francisco, CA, USA., Mellman I; Genentech, South San Francisco, CA, USA., Turley SJ; Genentech, South San Francisco, CA, USA. Turley.Shannon@gene.com., Müller S; Genentech, South San Francisco, CA, USA. Muller.Soren@gene.com.

Publikováno v: Nature communications [Nat Commun] 2023 Aug 05; Vol. 14 (1), pp. 4703. Date of Electronic Publication: 2023 Aug 05.

LRRC15 ⁺ myofibroblasts dictate the stromal setpoint to suppress tumour immunity.

Autor: Krishnamurty AT; Genentech, South San Francisco, CA, USA., Shyer JA; Genentech, South San Francisco, CA, USA., Thai M; Genentech, South San Francisco, CA, USA., Gandham V; Genentech, South San Francisco, CA, USA., Buechler MB; Genentech, South San Francisco, CA, USA., Yang YA; Genentech, South San Francisco, CA, USA., Pradhan RN; Genentech, South San Francisco, CA, USA., Wang AW; Genentech, South San Francisco, CA, USA., Sanchez PL; Genentech, South San Francisco, CA, USA., Qu Y; Genentech, South San Francisco, CA, USA., Breart B; Genentech, South San Francisco, CA, USA., Chalouni C; Genentech, South San Francisco, CA, USA., Dunlap D; Genentech, South San Francisco, CA, USA., Ziai J; Genentech, South San Francisco, CA, USA., Elstrott J; Genentech, South San Francisco, CA, USA., Zacharias N; Genentech, South San Francisco, CA, USA., Mao W; Genentech, South San Francisco, CA, USA., Rowntree RK; Genentech, South San Francisco, CA, USA., Sadowsky J; Genentech, South San Francisco, CA, USA., Lewis GD; Genentech, South San Francisco, CA, USA., Pillow TH; Genentech, South San Francisco, CA, USA., Nabet BY; Genentech, South San Francisco, CA, USA., Banchereau R; Genentech, South San Francisco, CA, USA., Tam L; Genentech, South San Francisco, CA, USA., Caothien R; Genentech, South San Francisco, CA, USA., Bacarro N; Genentech, South San Francisco, CA, USA., Roose-Girma M; Genentech, South San Francisco, CA, USA., Modrusan Z; Genentech, South San Francisco, CA, USA., Mariathasan S; Genentech, South San Francisco, CA, USA., Müller S; Genentech, South San Francisco, CA, USA. Muller.Soren@gene.com., Turley SJ; Genentech, South San Francisco, CA, USA. Turley.Shannon@gene.com.

Publikováno v: Nature [Nature] 2022 Nov; Vol. 611 (7934), pp. 148-154. Date of Electronic Publication: 2022 Sep 28.

An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.

Autor: Harman CCD; Department of Genetics, Yale School of Medicine, New Haven, CT 06520.; Howard Hughes Medical Institute, New Haven, CT 06520., Bailis W; Division of Protective Immunity, Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Zhao J; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520., Hill L; Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria., Qu R; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520., Jackson RP; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Shyer JA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Steach HR; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520., Kluger Y; Department of Pathology, Yale School of Medicine, New Haven, CT 06510.; Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520.; Applied Mathematics Program, Yale University, New Haven, CT 06511., Goff LA; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205., Rinn JL; Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115.; Department of Biochemistry, University of Colorado, BioFrontiers Institute, Boulder, CO 80301., Williams A; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032.; Department of Genetics and Genomic Sciences, University of Connecticut Health Center, Farmington, CT 06030., Henao-Mejia J; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Flavell RA; Howard Hughes Medical Institute, New Haven, CT 06520; richard.flavell@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 19; Vol. 118 (3).

Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses.

Autor: Low JS; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Farsakoglu Y; NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA., Amezcua Vesely MC; Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Centro de Investigaciones en Bioquímica Clínica e Inmunología, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba, Argentina., Sefik E; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Kelly JB; Department of Ecology and Evolutionary Biology, Stony Brook University, Stony Brook, NY., Harman CCD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Jackson R; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Shyer JA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Jiang X; Department of Immunobiology, Yale University School of Medicine, New Haven, CT., Cauley LS; Department of Immunology, University of Connecticut Health Center, Farmington, CT., Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; Howard Hughes Medical Institute, Yale University, New Haven, CT., Kaech SM; Department of Immunobiology, Yale University School of Medicine, New Haven, CT.; NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute for Biological Studies, La Jolla, CA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2020 Aug 03; Vol. 217 (8).