Výsledky vyhledávání - "Shyanne Salen"

Abstract 160: Derivation and long-term maintenance of patient-derived tumoroid lines in a defined, serum-free medium

Autor: Chris Yankaskas, Brittany Balhouse, Colin Paul, Shyanne Salen, Sybelle Djikeng, Pradip Shahi Thakuri, Mark Kennedy, Matt Dallas, David Kuninger

Publikováno v: Cancer Research. 83:160-160

In vitro cancer research often fails to translate to the clinic, in part due to the use of traditional 2D cancer cell lines as models, which fail to resemble primary cancer cells by a variety of measures, including high mutational burden. An emerging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5b37ff80d1a39a843035bd9b2253c1
https://doi.org/10.1158/1538-7445.am2023-160

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Abstract 2750: Multiplexed plate-reader based drug screening of 3D-tumoroid models

Autor: Xiaoyu Yang, Andrew Tsao, Garrett Wong, Chris Yankaskas, Colin Paul, Brittany Balhouse, Amber Bullock, Anthony Chatman, Shyanne Salen, Sybelle Djikeng, Matt Dallas, David Kuninger

Publikováno v: Cancer Research. 83:2750-2750

Cancer drug development is an extremely challenging and resource-consuming process with a dismal success rate of 5%. The high failure rate is partly due to the inadequacy of traditional 2D cell culture model to predict drug efficacy and toxicity. A h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f12bd934377d899e22d80f5d2ba7c067
https://doi.org/10.1158/1538-7445.am2023-2750

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Abstract 158: How low can you go: Maintenance of tumoroid phenotype with a highly scalable and automation-compatible reduced-ECM suspension culture method

Autor: Brittany N. Balhouse, Colin Paul, Chris Yankaskas, Shyanne Salen, Sybelle Djikeng, Pradip Shahi Thakuri, Anthony Chatman, Amber Bullock, Matthew Dallas, David Kuninger

Publikováno v: Cancer Research. 83:158-158

Tumoroid cultures, also known as cancer organoids, have been shown to maintain patient-specific mutational and gene expression profiles over the course of long-term culture better than traditional cancer lines. Despite the physiological relevance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b67d29207bdbbf1635b31459c70905e
https://doi.org/10.1158/1538-7445.am2023-158

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Abstract 2753: Engineering patient-derived tumors to enable high-throughput screening: Immuno-oncology workflows

Autor: Andrew Tsao, Xiaoyu Yang, Garrett Wong, Vivek Chandra, Jacob Delgadillo, Lindsay Bailey Steinitz, Brittany Balhouse, Colin Paul, Jakhan Nguyen, Sybelle Djikeng, Shyanne Salen, Jason Sharp, Matt Dallas, David Kuninger

Publikováno v: Cancer Research. 83:2753-2753

Aim/Introduction: In recent years, cancer immunotherapy has become one of the fastest-growing areas in cancer research. Selecting suitable and cost-effective experimental models for developing and validating immunotherapies is one of the major obstac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eb71e832105e266617fbcd91f5fd283
https://doi.org/10.1158/1538-7445.am2023-2753

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Abstract 177: Expansion of established patient-derived tumoroids in a novel serum-free, Wnt-free media system

Autor: Colin Paul, Brittany Balhouse, Chris Yankaskas, Shyanne Salen, Sybelle Djikeng, Pradip Shahi Thakuri, Matt Dallas, David Kuninger

Publikováno v: Cancer Research. 83:177-177

Tumoroid technology enables culture of patient tissue-derived cancer cells in 3D, with retention of key characteristics from the original patient tumor. However, current tumoroid culture relies on labor-intensive media formulations and culture workfl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32df176d52e13dce9072b0ac76247719
https://doi.org/10.1158/1538-7445.am2023-177

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