Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Autor: Christos Tziotzios, Christos Petridis, Nick Dand, Chrysanthi Ainali, Jake R. Saklatvala, Venu Pullabhatla, Alexandros Onoufriadis, Rashida Pramanik, David Baudry, Sang Hyuck Lee, Kristie Wood, Lu Liu, Seth Seegobin, Gregory A. Michelotti, Su M. Lwin, Evangelos A. A. Christou, Charles J. Curtis, Emanuele de Rinaldis, Alka Saxena, Susan Holmes, Matthew Harries, Ioulios Palamaras, Fiona Cunningham, Gregory Parkins, Manjit Kaur, Paul Farrant, Andrew McDonagh, Andrew Messenger, Jennifer Jones, Victoria Jolliffe, Iaisha Ali, Michael Ardern-Jones, Charles Mitchell, Nigel Burrows, Ravinder Atkar, Cedric Banfield, Anton Alexandroff, Caroline Champagne, Hywel L. Cooper, Sergio Vañó-Galván, Ana Maria Molina-Ruiz, Nerea Ormaechea Perez, Girish K. Patel, Abby Macbeth, Melanie Page, Alyson Bryden, Megan Mowbray, Shyamal Wahie, Keith Armstrong, Nicola Cooke, Mark Goodfield, Irene Man, David de Berker, Giles Dunnill, Anita Takwale, Archana Rao, Tee-Wei Siah, Rodney Sinclair, Martin S. Wade, Ncoza C. Dlova, Jane Setterfield, Fiona Lewis, Kapil Bhargava, Niall Kirkpatrick, Xavier Estivill, Catherine M. Stefanato, Carsten Flohr, Timothy Spector, Fiona M. Watt, Catherine H. Smith, Jonathan N. Barker, David A. Fenton, Michael A. Simpson, John A. McGrath

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

Frontal fibrosing alopecia (FFA) features lichenoid cutaneous inflammation and scarring hair loss. Here, Tziotzios et al. identify four genetic loci associated with FFA by GWAS followed by Bayesian fine-mapping, co-localisation and HLA imputation whi

Externí odkaz: https://doaj.org/article/2a42af5d272646528b4002af71d71088

Damaging alleles affecting multiple CARD14 domains are associated with palmoplantar pustulosis

Autor: Athanasios Niaouris, Ariana Hernández-Cordero, Salma Haddad, Niina Karoliina Hassi, Natashia Benzian-Olsson, Carmen Bugarin Diz, A. David Burden, Hywel L. Cooper, Christopher E.M. Griffiths, Richard Parslew, Andrew E. Pink, Nick J. Reynolds, Shyamal Wahie, Richard B. Warren, Andrew Wright, Michael Simpson, Patrick Baum, Sudha Visvanathan, Jonathan N. Barker, Catherine H. Smith, Francesca Capon, Thamir Abraham, Muhmad Ali, Suzannah August, David Baudry, Gabrielle Becher, Anthony Bewley, Victoria Cornelius, Giles Dunnill, Adam Ferguson, Sharizan Ghaffar, John Ingram, Svetlana Kavakleiva, Susan Kelly, Mohsen Khorshid, Helen Lachmann, Effie Ladoyanni, Helen McAteer, John McKenna, Freya Meynell, Nick Levell, Prakash Patel, Angela Pushparajah, Catriona Sinclair, Rachel Wachsmuth, Rosemary Wilson

Publikováno v: The Journal of investigative dermatology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749136af9a8ff21cde33671ded23bd66
https://pubmed.ncbi.nlm.nih.gov/36174714

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

Autor: Paul Farrant, Mark Goodfield, Catherine H. Smith, V. Jolliffe, Gregory Parkins, Caroline Champagne, Lu Liu, Nigel Burrows, A. S. Bryden, Kristie Wood, Anton B. Alexandroff, Irene Man, Alka Saxena, Su M. Lwin, Iaisha Ali, Catherine M. Stefanato, Kapil Bhargava, Sang Hyuck Lee, Melanie Page, Xavier Estivill, Tim D. Spector, Carsten Flohr, Susan Holmes, David de Berker, A. E. Macbeth, Ncoza C. Dlova, David Baudry, Jake Saklatvala, Nerea Ormaechea Perez, Archana Rao, David A. Fenton, Martin S Wade, Cedric Charles Banfield, Jennifer Jones, Evangelos A A Christou, Ravinder Atkar, Gregory A Michelotti, Sergio Vano-Galvan, Seth D. Seegobin, Jane Setterfield, Jonathan Barker, Chrysanthi Ainali, Christos Tziotzios, Charles Curtis, Rashida Pramanik, Matthew Harries, Girish K Patel, Niall Kirkpatrick, Venu Pullabhatla, Fiona Cunningham, Nick Dand, Hywel L Cooper, Rodney Sinclair, Keith Armstrong, Emanuele de Rinaldis, Andrew J. G. McDonagh, M R Kaur, Fiona Lewis, Michael A. Simpson, John A. McGrath, Charles E. Mitchell, Nicola Cooke, Fiona M. Watt, Alexandros Onoufriadis, Michael R. Ardern-Jones, Tee-Wei Siah, Ioulios Palamaras, Ana María Molina-Ruiz, Megan Mowbray, A. Takwale, Andrew G. Messenger, Giles Dunnill, Christos Petridis, Shyamal Wahie

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T-W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w
Tziotzios, C, Petridis, C, Dand, N, Ainali, C, Saklatvala, J R, Pullabhatla, V, Onoufriadis, A, Pramanik, R, Baudry, D, Lee, S H, Wood, K, Liu, L, Seegobin, S, Michelotti, G A, Lwin, S M, Christou, E A A, Curtis, C J, de Rinaldis, E, Saxena, A, Holmes, S, Harries, M, Palamaras, I, Cunningham, F, Parkins, G, Kaur, M, Farrant, P, McDonagh, A, Messenger, A, Jones, J, Jolliffe, V, Ali, I, Ardern-Jones, M, Mitchell, C, Burrows, N, Atkar, R, Banfield, C, Alexandroff, A, Champagne, C, Cooper, H L, Vañó-Galván, S, Molina-Ruiz, A M, Perez, N O, Patel, G K, Macbeth, A, Page, M, Bryden, A, Mowbray, M, Wahie, S, Armstrong, K, Cooke, N, Goodfield, M, Man, I, de Berker, D, Dunnill, G, Takwale, A, Rao, A, Siah, T W, Sinclair, R, Wade, M S, Dlova, N C, Setterfield, J, Lewis, F, Bhargava, K, Kirkpatrick, N, Estivill, X, Stefanato, C M, Flohr, C, Spector, T, Watt, F M, Smith, C H, Barker, J N, Fenton, D A, Simpson, M A & McGrath, J A 2019, ' Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02 ', Nature Communications, vol. 10, no. 1, 1150 . https://doi.org/10.1038/s41467-019-09117-w

Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::815bee1165012831508b4694bef65cc2
https://doaj.org/article/2a42af5d272646528b4002af71d71088

Home-based narrowband UVB, topical corticosteroid or combination for children and adults with vitiligo: HI-Light Vitiligo three-arm RCT

Autor: Lelia Duley, Jane Ravenscroft, Paul Leighton, Rachel H. Haines, J. M. R. Goulding, Nick J. Levell, Julia Stainforth, Andrew Rogers, Amirtha Rajasekaran, Adam Ferguson, M. Ogboli, Adam Millington, Garry Meakin, Seau Tak Cheung, Perways Akram, Anthony Bewley, Hywel C Williams, Shyamal Wahie, Viktoria Eleftheriadou, Jonathan M. Batchelor, Bisola Laguda, Tracey Sach, Maxine E Whitton, Jennifer White, Wei Tan, Andrew Wright, Miriam Santer, Joanne R Chalmers, Hamdi Hamad, Jaskiran Azad, John R. Ingram, Alan A Montgomery, Areti Makrygeorgou, Kim S Thomas, Robert Ellis

Publikováno v: Health Technol Assess
Health Technology Assessment, Vol 24, Iss 64 (2020)

BackgroundSystematic reviews suggest that narrowband ultraviolet B light combined with treatments such as topical corticosteroids may be more effective than monotherapy for vitiligo.ObjectiveTo explore the clinical effectiveness and cost-effectivenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b540d4919237a630fae46a21aa5b998
https://pubmed.ncbi.nlm.nih.gov/33245043

Association of Clinical and Demographic Factors With the Severity of Palmoplantar Pustulosis

Autor: Hywel L Cooper, Kaspar Torz, Jonathan Barker, Zsuzsa Bata-Csorgo, Tejus Dasandi, Charlotte Chaloner, Helen J. Lachmann, R Parslew, Natashia Benzian-Olsson, Plum study team, H. McAteer, Sulev Kõks, F. Meynell, Richard B. Warren, Victoria Cornelius, Prakash Patel, Shyamal Wahie, Külli Kingo, Catherine H. Smith, Christopher E.M. Griffiths, Adrian Tanew, Andrew Wright, Alexander A. Navarini, Andrew Pink, Ulrich Mrowietz, Suzie Cro, A. David Burden, Riccardo G. Borroni, Francesca Capon, Nick J. Reynolds, Hannes Trattner, Nick Dand

Publikováno v: JAMA Dermatology
JAMA Dermatol

Key Points Question Are clinical and demographic factors associated with the severity of palmoplantar pustulosis? Findings In a cross-sectional study of 203 patients in the UK, the Palmoplantar Pustulosis Psoriasis Area Severity Index score was signi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06873761862527144aa03bbc9de10f87
https://pubmed.ncbi.nlm.nih.gov/32936291