Zobrazeno 1 - 3
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pro vyhledávání: '"Shyam Yadati"'
Autor:
William F. Wade, Doug Demian, Jerome L. Gabriel, B. George Barisas, Thomas Nydam, Shyam Yadati, Terri K. Wade
Publikováno v:
Immunology Letters. 67:47-55
Class II dimers of dimers are predicted to have functional significance in antigen presentation. The putative contact amino acids of the I-Ak class II dimer of dimers have been identified by molecular modeling based on the DR1 crystal structure (Nyda
Publikováno v:
International Immunology. 10:1237-1249
The recent solutions of the MHC class II crystal structure reveal dimerization of the alphabeta heterodimers. These dimer of dimers structures may also exist either on resting cells or after engagement by TCR, and may be involved in B cell signaling
Autor:
Shyam Yadati, E. Scott Seeley, William F. Wade, Terri K. Wade, Mark L. Lang, Grant R. Yeaman, B. George Barisas, Thom Nydam, Jerome L. Gabriel
Publikováno v:
International immunology. 12(6)
A previous investigation demonstrated that several mutations in class II dimer-of-dimers contact residues interfere with antigen presentation by transfectants but not with plasma membrane expression of the mutant class II. In the present study we exa