Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Shyam Sundhar Bale"'
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilitySummary
Autor:
Jay Luther, John J. Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L. Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R. Turner, Martin L. Yarmush, Raymond T. Chung, Suraj J. Patel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 222-232.e2 (2015)
Background & Aims: Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have inves
Externí odkaz:
https://doaj.org/article/af64a40e688a4485a116866d0e616577
Autor:
Alireza Abazari, Labros G Meimetis, Ghyslain Budin, Shyam Sundhar Bale, Ralph Weissleder, Mehmet Toner
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130323 (2015)
Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and extracellular trehalose has bee
Externí odkaz:
https://doaj.org/article/0d96867c753b4a4db1e94e57d7ebf734
Autor:
Gautham Vivek Sridharan, Bote Gosse Bruinsma, Shyam Sundhar Bale, Anandh Swaminathan, Nima Saeidi, Martin L. Yarmush, Korkut Uygun
Publikováno v:
Metabolites, Vol 7, Iss 4, p 58 (2017)
Large-scale -omics data are now ubiquitously utilized to capture and interpret global responses to perturbations in biological systems, such as the impact of disease states on cells, tissues, and whole organs. Metabolomics data, in particular, are di
Externí odkaz:
https://doaj.org/article/2974eadb832c48b5b4b648371a189e7c
Autor:
Shyam Sundhar Bale, Kelly Tan, Joe Charest, Mingjian Lu, James R. Gosset, Miles Rogers, Philip M. Keegan
Publikováno v:
Lab on a Chip. 19:1556-1566
Microphysiological systems (MPSs) are dynamic cell culture systems that provide micro-environmental and external cues to support physiologically relevant, organ-specific functions. Recent progresses in MPS fabrication technologies have enabled the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2f57cbe470de4c8fa44bf86c8cd6ab
https://doi.org/10.1039/c8lc01262h
https://doi.org/10.1039/c8lc01262h
Autor:
T J Mulhern, Ashley L. Gard, Brett C. Isenberg, Ernest S. Kim, Kelly Tan, Vishal Tandon, Shyam Sundhar Bale, Miles Rogers, Jonathan R. Coppeta, J C de Souza, B C Hoefler, A Zorn, K B Baldwin, E L Wiellette, Else M. Vedula, Matthew P. Lech, Joseph L. Charest, Louis B. Kratchman, A Patterson, Philip M. Keegan, Hesham Azizgolshani, Nerses J. Haroutunian, E E Marr, S H Kann, Corin Williams, B P Cain, R J Luu, T A Petrie
Publikováno v:
Lab on a chip. 21(8)
Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue in vitro, therefore providing a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0a71b425453dd13b6fdb6d5d297338
https://pubmed.ncbi.nlm.nih.gov/33881130
https://pubmed.ncbi.nlm.nih.gov/33881130
Autor:
Nerses J. Haroutunian, Kelly Tan, Vishal Tandon, Else M. Vedula, Brett C. Isenberg, Philip M. Keegan, Louis B. Kratchman, Miles Rogers, Jonathan R. Coppeta, Shyam Sundhar Bale, Hesham Azizgolshani, Veronica Newlin, Stephanie Golmon, B P Cain, Mingjian Lu, Ernest S. Kim, Joseph L. Charest, James R. Gosset, Abigail J Patterson
Publikováno v:
Lab on a chip. 20(19)
Correction for ‘A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions’ by Kelly Tan et al., Lab Chip, 2019, 19, 1556–1566, DOI: 10.1039/C8LC01262H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68894f22f5b4480435d1dcb4b53b14
https://pubmed.ncbi.nlm.nih.gov/30855604
https://pubmed.ncbi.nlm.nih.gov/30855604
Autor:
Vicky H. Bhagat, Matthew D’Alessandro, Shyam Sundhar Bale, Nima Saeidi, John M. Asara, Korkut Uygun, Hugo Gagnon, Martin L. Yarmush, Gautham V. Sridharan
Publikováno v:
TECHNOLOGY. :139-184
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a8ba04228dec2e856c015c88356f5d
https://doi.org/10.1142/s233954781750008x
https://doi.org/10.1142/s233954781750008x
Autor:
Mingjian Lu, Joseph L. Charest, Kelly Tan, Philip M. Keegan, Miles Rogers, Shyam Sundhar Bale, James R. Gosset
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbd67ba1bc12bf10a81c979622bd1bb3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.508.1
https://doi.org/10.1096/fasebj.2019.33.1_supplement.508.1
Autor:
Alex Markoski, Hesham Azizgolshani, Shyam Sundhar Bale, Philip M. Keegan, B P Cain, Mingjian Lu, Joseph L. Charest, Jonathan R. Coppeta, James R. Gosset, Andrea Manoppo, Rebecca Thompson, Veronica Newlin, Abbie Spencer, Nerses J. Haroutunian
Publikováno v:
Biotechnology and bioengineering. 116(12)
Hepatic in vitro platforms ranging from multi-well cultures to bioreactors and microscale systems have been developed as tools to recapitulate cellular function and responses to aid in drug screening and disease model development. Recent developments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba45ddae8cd9e938d3fbab4362af0ab
https://pubmed.ncbi.nlm.nih.gov/30963546
https://pubmed.ncbi.nlm.nih.gov/30963546
Autor:
Jay Luther, Martin L. Yarmush, Nadia Alatrakchi, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Anna Lidofsky, Rohit Jindal, Shyam Sundhar Bale, Cynthia Brisac, Dahlene N. Fusco, Wenyu Lin, Esperance A. Schaefer, Jacinta A. Holmes
Publikováno v:
Hepatology. 64:1951-1968
HIV/HCV co-infection accelerates progressive liver fibrosis, however the mechanisms remain poorly understood. HCV and HIV independently induce profibrogenic markers TGFβ1 (mediated by reactive oxygen species (ROS)) and NFκB in hepatocytes and hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31a3539b8c3e32d6aab65caa3ebd5f66
https://doi.org/10.1002/hep.28766
https://doi.org/10.1002/hep.28766