Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Shyam S. Chaurasia"'
Autor:
Binapani Mahaling, Shermaine W. Y. Low, Sanjay Ch, Utkarsh R. Addi, Baseer Ahmad, Thomas B. Connor, Rajiv R. Mohan, Swati Biswas, Shyam S. Chaurasia
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 2005 (2023)
Retinal diseases are one of the leading causes of blindness globally. The mainstay treatments for these blinding diseases are laser photocoagulation, vitrectomy, and repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) o
Externí odkaz:
https://doaj.org/article/f9e8af99070c4369a9c133dc2d11646e
Autor:
Nishant R. Sinha, Ratnakar Tripathi, Praveen K. Balne, Laila Suleiman, Katherine Simkins, Shyam S. Chaurasia, Rajiv R. Mohan
Publikováno v:
Cells, Vol 12, Iss 11, p 1533 (2023)
Sulfur mustard gas (SM) is a vesicating and alkylating agent used as a chemical weapon in many mass-casualty incidents since World War I. Ocular injuries were reported in >90% of exposed victims. The mechanisms underlying SM-induced blindness remain
Externí odkaz:
https://doaj.org/article/500184f05b8b49a78131c9daf053e137
Autor:
Vishnu Suresh Babu, Atish Kizhakeyil, Gagan Dudeja, Shyam S. Chaurasia, Veluchami Amutha Barathi, Stephane Heymans, Navin Kumar Verma, Rajamani Lakshminarayanan, Arkasubhra Ghosh
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2507 (2022)
Host defense peptides represent an important component of innate immunity. In this work, we report the anticancer properties of a panel of hyper-charged wholly cationic antimicrobial dodecapeptides (CAPs) containing multiple canonical forms of lysine
Externí odkaz:
https://doaj.org/article/29ede6e1a7af488086024112c42a49d1
Autor:
Vishnu Suresh Babu, Ashwin Mallipatna, Deepak SA, Gagan Dudeja, Ramaraj Kannan, Rohit Shetty, Archana Padmanabhan Nair, Seetharamanjaneyulu Gundimeda, Shyam S. Chaurasia, Navin Kumar Verma, Rajamani Lakshminarayanan, Stephane Heymans, Veluchamy A. Barathi, Nilanjan Guha, Arkasubhra Ghosh
Publikováno v:
Cells, Vol 11, Iss 10, p 1668 (2022)
Retinoblastoma (Rb) is a pediatric intraocular malignancy that is proposed to originate from maturing cone cell precursors in the developing retina. The molecular mechanisms underlying the biological and clinical behaviors are important to understand
Externí odkaz:
https://doaj.org/article/2db444344ec8460ba872dd3d639fa872
Autor:
Binapani Mahaling, Shermaine W. Y. Low, Molly Beck, Devesh Kumar, Simrah Ahmed, Thomas B. Connor, Baseer Ahmad, Shyam S. Chaurasia
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2591 (2022)
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation ca
Externí odkaz:
https://doaj.org/article/fa6c0ab547ed4f81beb5d6bcc59f33f5
Autor:
Shermaine W. Y. Low, Tanuja Vaidya, Santosh G. K. Gadde, Thirumalesh B. Mochi, Devesh Kumar, Iris S. Kassem, Deborah M. Costakos, Baseer Ahmad, Swaminathan Sethu, Arkasubhra Ghosh, Shyam S. Chaurasia
Publikováno v:
Life, Vol 11, Iss 12, p 1421 (2021)
Diabetic retinopathy (DR) is a microvascular complication of diabetes in the retina. Chronic hyperglycemia damages retinal microvasculature embedded into the extracellular matrix (ECM), causing fluid leakage and ischemic retinal neovascularization. C
Externí odkaz:
https://doaj.org/article/4b26c095a0644d0c946bbdc0fb94c958
Autor:
Shyam S. Chaurasia, Rayne R. Lim, Bhav H. Parikh, Yeo Sia Wey, Bo Bo Tun, Tien Yin Wong, Chi D. Luu, Rupesh Agrawal, Arkasubhra Ghosh, Alessandra Mortellaro, Elizabeth Rackoczy, Rajiv R. Mohan, Veluchamy A. Barathi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in a double transgenic mouse model, Akimba (Ins2 Akita xVEGF +/−), which dem
Externí odkaz:
https://doaj.org/article/f5819ad73a044bfe965b05e365cb38eb
Autor:
Shermaine W. Y. Low, Thomas B. Connor, Iris S. Kassem, Deborah M. Costakos, Shyam S. Chaurasia
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7293 (2021)
Retinal diseases such as age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy (DR) are the leading causes of visual impairment worldwide. There is a critical need to understand the structural and cellular
Externí odkaz:
https://doaj.org/article/dbea58890d904511a793af108e31311b
Autor:
Rayne R. Lim, Margaret E. Wieser, Rama R. Ganga, Veluchamy A. Barathi, Rajamani Lakshminarayanan, Rajiv R. Mohan, Dean P. Hainsworth, Shyam S. Chaurasia
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 899 (2020)
Diabetic retinopathy (DR) is an ocular complication of diabetes mellitus (DM). International Diabetic Federations (IDF) estimates up to 629 million people with DM by the year 2045 worldwide. Nearly 50% of DM patients will show evidence of diabetic-re
Externí odkaz:
https://doaj.org/article/0fcb59f584e7423eb795a782b6bdc722
Publikováno v:
Journal of Functional Biomaterials, Vol 6, Iss 2, Pp 277-298 (2015)
Corneal diseases are the third leading cause of blindness globally. Topical nonsteroidal anti-inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used to treat corneal pathological conditions. However, barrier
Externí odkaz:
https://doaj.org/article/9edcdfe007fe49608273eed98e793c58