Výsledky vyhledávání - "Shyam Nathan"

Akademický článek

Comparative transcriptomic analysis validates iPSC derived in-vitro progressive fibrosis model as a screening tool for drug discovery and development in systemic sclerosis

Autor: Shyam Nathan, Yifei Wang, Matthew D’ambrosio, Reeba Paul, Huimin Lyu, Denis Delic, Tom Bretschneider, Kimberly Falana, Li Li, Preethi Vijayaraj

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, immune dysregulation, and systemic fibrosis. Research on SSc has been hindered largely by lack of relevant models to study the progressive nature of the disease

Externí odkaz: https://doaj.org/article/4f95fef11cd74158aa182d9c109c859b

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Akademický článek

CREB-dependent LPA-induced signaling initiates a pro-fibrotic feedback loop between small airway basal cells and fibroblasts

Autor: Shyam Nathan, Haijun Zhang, Mirko Andreoli, Philip L. Leopold, Ronald G. Crystal

Publikováno v: Respiratory Research, Vol 22, Iss 1, Pp 1-18 (2021)

Abstract Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the l

Externí odkaz: https://doaj.org/article/9e2d4f908e8c4f36b832ace6bff5acbd

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BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer cells

Autor: Eliot M. Rosen, Shyam Nathan, Milton L. Brown, Eliseu O. De Oliveira, York A. Tomita, Yongxian Ma

We previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic the ability of BRCA1 to inhibit ERα activity (“BRCA1-mimetics”), and overcome antiestrogen resistance. One such compound,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e5108049e0f3c9d56b15e913222d55
https://europepmc.org/articles/PMC5681404/

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Abstract 3602: Novel BRCA1 mimetic 35446HCl inhibits growth of anti estrogen resistant breast cancer cells through the NF-κB pathway

Autor: Shyam Nathan, Eliot M. Rosen

Publikováno v: Cancer Research. 77:3602-3602

Nearly a third of breast cancer patients develop resistance to antiestrogen treatments although the estrogen receptor ER-α continues to affect cell survival and proliferation. Thus there is a need for new interventions to inhibit ER-α function. Bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d37e2fa2e6da56c1a35a2064fc81d36f
https://doi.org/10.1158/1538-7445.am2017-3602

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Small-Molecule 'BRCA1-Mimetics' Are Antagonists of Estrogen Receptor-α

Autor: Eliseu O. De Oliveira, Anju Preet, Eliot M. Rosen, Scott Grindrod, Shyam Nathan, Milton L. Brown, Erikah Englund, Robert Clarke, York Tomita, Yongxian Ma

Context: Resistance to conventional antiestrogens is a major cause of treatment failure and, ultimately, death in breast cancer. Objective: The objective of the study was to identify small-molecule estrogen receptor (ER)-α antagonists that work diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8b55bd65a910fd7488b8458938d8eb
https://europepmc.org/articles/PMC4250363/

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