Výsledky vyhledávání - "Shyam M. Rele"

Autor: Elliot L. Chaikof, Vincent P. Conticello, Shyam M. Rele, Zheng Qu, Yuhua Song, Robert P. Apkarian

Publikováno v: Journal of the American Chemical Society. 129:14780-14787

Self-assembling peptides have been previously designed that assemble into macroscopic membranes, nanotapes, and filaments through electrostatic interactions. However, the formation of highly ordered collagen-like fibrils, which display D-periodic fea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811e07087d30d4316e4355e15f1f7b41
https://doi.org/10.1021/ja0758990

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Design and synthesis of hyaluronan-mimetic gemini disaccharides

Autor: Subramanian Baskaran, Shyam M. Rele, Elliot L. Chaikof, Suri S. Iyer

Publikováno v: Tetrahedron. 59:631-638

An efficient strategy has been designed for the preparation of synthetic mimics of hyaluronan (HA, 1) and its dimerized (Gemini) disaccharides (2a,b) via n-pentenyl glycoside formation. Construction of the target molecules was achieved through a comb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bc75505224d3822fc25a58c599df78f
https://doi.org/10.1016/s0040-4020(02)01567-3

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Homodimerization of hyaluronan and heparan sulfate derivatives by olefin metathesis reaction

Autor: Shyam M. Rele, Suri S. Iyer, Elliot L. Chaikof

Publikováno v: Tetrahedron Letters. 44:89-91

Hyaluronan and heparan sulfate disaccharides of the type β- d -glucuronic acid-(1→3)- N -acetyl-β- d -glucosamine and α- l -iduronic acid-(1→4)- N -acetyl-β- d -glucosamine, respectively, with an n -pentenyl group at the reducing end have bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3c18d32429926e8a50aecfe87d7453f
https://doi.org/10.1016/s0040-4039(02)02482-6

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Hyaluronan-based Glycoclusters as Probes for Chemical Glycobiology

Autor: Elliot L. Chaikof, Shyam M. Rele, Suri S. Iyer

Publikováno v: Tetrahedron letters. 48(29)

A strategy is described for the synthesis of β-(1,3)-GlcA-GlcNAc dimeric and tetrameric glycoclusters through the conjugation of disaccharide groups onto a diaminodiamide aromatic scaffold by reductive amination.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4551cb6074d8b267ddd0482f2f69906
https://pubmed.ncbi.nlm.nih.gov/19847317

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

Autor: Douglas J. Kornbrust, Shyam M. Rele, Joanna Yi-Ching Liu, Mark E. Davis, Zhongping Yu, Jeremy D. Heidel, Yongchao Liang, Ryan K. Zeidan

The results of administering escalating, i.v. doses of targeted nanoparticles containing a siRNA targeting the M2 subunit of ribonucleotide reductase to non-human primates are reported. The nanoparticles consist of a synthetic delivery system that us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e93c750f3ba99504acd973e81db64aa
https://resolver.caltech.edu/CaltechAUTHORS:HEIpnas07

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Fabrication and characterization of heparin functionalized membrane-mimetic assemblies

Autor: Po-Yuan Tseng, Elliot L. Chaikof, Shyam M. Rele, Xue-Long Sun

Publikováno v: Biomaterials. 27(12)

A membrane-mimetic assembly incorporating surface bound heparin was fabricated as a system to improve the hemocompatibility of blood-contacting devices. As a model system, heparin was chemically modified by end-point conjugation to biotin and immobil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70c42f657e1e73c528498cd30067f73
https://pubmed.ncbi.nlm.nih.gov/16368135

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Dendrimer-like PEO glycopolymers exhibit anti-inflammatory properties

Autor: Daniel Tatton, Jeffrey D. Esko, Wanxing Cui, Elliot L. Chaikof, Shyam M. Rele, Ginger Barr-Zarse, Lianchun Wang, Yves Gnanou, Sijian Hou

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2005, 127 (29), pp.10132-10133. ⟨10.1021/ja0511974⟩

A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63fb16e987179de21eef7469dc7027d
http://hdl.handle.net/20.500.12278/20674

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Design and synthesis of dimeric heparinoid mimetics

Autor: Subramanian Baskaran, Shyam M. Rele, Suri S. Iyer, Elliot L. Chaikof

Publikováno v: The Journal of organic chemistry. 69(26)

Synthetic oligosaccharide constructs exhibiting tailored and well-defined heparan sulfate (HS) like sequences offer the potential to modulate dynamic HS-dependent biomolecular recognition processes. We report an efficient strategy for the generation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed34e23c05802a8cbde1d7319490d3f0
https://pubmed.ncbi.nlm.nih.gov/15609950

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