Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

Autor: Qi Tony Zhou, Yuchuan Gong, Lynne S. Taylor, Biplob Mitra, Shyam Karki, Uday Jain, Sumit Kumar, Anjali Agrawal, Sonal V Bhujbal

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2505-2536 (2021)
Acta Pharmaceutica Sinica. B

Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067adf8960eedbc9499e5e3d7319e5f5
http://www.sciencedirect.com/science/article/pii/S2211383521001805

Development of low dose micro-tablets by high shear wet granulation process

Autor: Prajwal Thool, Shyam Karki, Anjali Agrawal, Jhalak Patel, Jianmin Li, William Bowen, Saikishore Meruva, Biplob Mitra, Shashwat Gupta

Publikováno v: International journal of pharmaceutics. 587

Low dose micro-tablets with acceptable quality attributes, specifically content uniformity (CU), would not only enhance the dose flexibility in the clinic, but also decrease excipient burden in pediatric population. Considering the CU challenges asso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf10c527f57754ad586898a880bd52f
https://pubmed.ncbi.nlm.nih.gov/32652180

Decoding the small size challenges of mini-tablets for enhanced dose flexibility and micro-dosing

Autor: Biplob Mitra, Prajwal Thool, Jhalak Patel, Kuldip Patel, William Bowen, Jianmin Li, Shyam Karki, Anjali Agarwal, Saikishore Meruva, J. Alex Aycinena

Publikováno v: International Journal of Pharmaceutics. 574:118905

Mini-tablets are an age appropriate dosage form for oral administration to pediatric and geriatric patients, either as individual mini-tablets or as composite dosage units. Smaller size mini-tablets than the commonly used 2 mm or larger size would of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3821f85f0724ae5143e81db2fb82ac
https://doi.org/10.1016/j.ijpharm.2019.118905

Downstream processing of irbesartan nanocrystalline suspension and mini-tablet development – Part II

Autor: Prajwal Thool, Ghosh Indrajit, Saikishore Meruva, Sumit Kumar, William Bowen, Shyam Karki

Publikováno v: International Journal of Pharmaceutics. 568:118509

The objectives of this study were to evaluate the impact of formulation variables on the drying of nanocrystalline suspensions either via bead layering or spray granulation and develop mini-tablets from the dried nanocrystalline powders. Irbesartan (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef19a9ceba575aacdcf50f7c355acbe
https://doi.org/10.1016/j.ijpharm.2019.118509

Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration

Autor: John Comer, Robert Taylor, Robert Price, Shyam Karki, Nikoletta Fotaki, Karl J. Box, Rebeca Ruiz

Publikováno v: Box, K J, Comer, J, Taylor, R, Karki, S, Ruiz, R, Price, R & Fotaki, N 2016, ' Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration ', AAPS PharmSciTech, vol. 17, no. 2, pp. 245-251 . https://doi.org/10.1208/s12249-015-0362-5

The purpose of this study was to better understand the dissolution properties and precipitation behavior of pharmaceutical cocrystals of poorly soluble drugs for the potential for oral administration based on a small-scale dissolution assay. Carbamaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f8cfc49e5a3c522b19f108532bd4e1
https://purehost.bath.ac.uk/ws/files/125255314/AAPSPharmSciTech_ACCEPTED_Dr_N_Fotaki.pdf