Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shweta R. Ugaonkar"'
Autor:
Aixa Rodriguez, Keith Levendosky, Larisa Kizima, Shweta R. Ugaonkar, Thomas M. Zydowsky, José A. Fernández-Romero, Olga Mizenina, Manjari Lal, Manshun Lai, Asa Wesenberg
Publikováno v:
Journal of Pharmaceutical Sciences. 107:2601-2610
Precoital, on-demand topical microbicides to reduce a woman's risk of sexually transmitted infections have been in development for nearly 3 decades, but no product has been approved due to acceptability issues and poor adherence in clinical trials. W
Autor:
Brooke Grasperge, James Blanchard, Jeffrey D. Lifson, Michael Benson, Nina Derby, José A. Fernández-Romero, Olga Mizenina, Walid Heneine, M. Melissa Peet, Zachary Lloyd, Aixa Rodriguez, Shweta R. Ugaonkar, Meropi Aravantinou, Agegnehu Gettie, Thomas M. Zydowsky, Patrick Barnable, Manshun Lai, Manjari Lal, Asa Wesenberg, Melissa Robbiani, Natalia Teleshova, Barry R. O'Keefe, Larisa Kizima, Elena Martinelli, Kyle R. Kleinbeck, Keith Levendosky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment options in individuals who become infected.
Autor:
Meropi Aravantinou, Michael L. Cooney, Keith Levendosky, James Blanchard, Brooke Grasperge, Jessica Kenney, José A. Fernández-Romero, Jolanta Wilk, Samantha Seidor, Shweta R. Ugaonkar, Shimin Zhang, Michael Piatak, Olga Mizenina, Melissa Robbiani, Larisa Kizima, Thomas M. Zydowsky, Jeffrey D. Lifson, Aixa Rodriguez, Nina Derby, Agegnehu Gettie, Asa Wesenberg
Publikováno v:
Drug Delivery and Translational Research
Women globally need access to multipurpose prevention technologies (MPTs) that prevent human immunodeficiency virus (HIV), sexually transmitted infections that increase HIV acquisition/transmission risk, and unintended pregnancy. Seeking an MPT with
Autor:
Justin T. Clark, Shweta R. Ugaonkar, Lexie B. English, Todd J. Johnson, Robert J. Bahde, Robert W. Buckheit, Patrick F. Kiser, Daniel H. Appella, Karen W. Buckheit
Publikováno v:
Journal of Pharmaceutical Sciences. 104:3426-3439
Nucleocapsid 7 (NCp7) inhibitors have been investigated extensively for their role in impeding the function of HIV-1 replication machinery and their ability to directly inactivate the virus. A class of NCp7 zinc finger inhibitors, S-acyl-2-mercaptobe
Autor:
Garry Gwozdz, Cory Shetler, Charlene S. Dezzutti, Shweta R. Ugaonkar, Karen W. Buckheit, Robert W. Buckheit, Alamelu Mahalingam
Publikováno v:
Antiviral Research. 96:221-225
Tenofovir (TFV) is a nucleotide reverse transcriptase inhibitor and IQP-0528 is a non-nucleoside reverse transcriptase inhibitor that also blocks virus entry. TFV and IQP-0528 alone have shown antiviral activity as microbicide gels. Because combinati
Autor:
Michael L. Cooney, Natalia Teleshova, Agegnehu Gettie, Melissa Robbiani, James Blanchard, José A. Fernández-Romero, Giulia Calenda, Guillermo Villegas, Larisa Kizima, Shweta R. Ugaonkar, Shimin Zhang, Thomas M. Zydowsky, Olga Mizenina
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159332 (2016)
PLoS ONE
PLoS ONE
Women need multipurpose prevention products (MPTs) that protect against sexually transmitted infections (STIs) and provide contraception. The Population Council has developed a prototype intravaginal ring (IVR) releasing the non-nucleoside reverse tr
Autor:
Garry Gwozdz, Karen W. Buckheit, Howard Y. Lakougna, Umadevi Nagaraja, Lianjun Shi, Robert W. Buckheit, Laurie Goldman, Shweta R. Ugaonkar, Anthony S. Ham, Patrick F. Kiser
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1423-1435
In light of the increasing worldwide AIDS pandemic, there is a continuing need to develop new prevention strategies to inhibit the transmission of HIV-1. In the absence of a successful vaccine, topical microbicides represent the best strategies to re
Autor:
Robert W. Buckheit, Patrick F. Kiser, Lisa C. Rohan, Adam P. Simmons, Karen M. Watson, Shweta R. Ugaonkar, Charlene S. Dezzutti, Alamelu Mahalingam
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:1650-1660
Pyrimidinediones, a novel class of compounds, have previously been shown to possess antiviral activity at nanomolar concentrations. One member of this class of compounds, IQP-0528, was selected as the lead molecule for formulation development owing t
Autor:
Meropi Aravantinou, Jessica Kenney, James Blanchard, José A. Fernández-Romero, Jolanta Wilk, Larisa Kizima, Samantha Seidor, Kevin Roberts, Melissa Robbiani, Narender Kumar, Keith Levendosky, Brooke Grasperge, Asa Wesenberg, Olga Mizenina, Thomas M. Zydowsky, Shweta R. Ugaonkar, Shimin Zhang, Agegnehu Gettie, Nina Derby, Aixa Rodriguez
Publikováno v:
Journal of Controlled Release. :57-68
Women urgently need a self-initiated, multipurpose prevention technology (MPT) that simultaneously reduces their risk of acquiring HIV-1, HSV-2, and HPV (latter two associated with increased risk of HIV-1 acquisition) and prevents unintended pregnanc