Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shwe Gyaw"'
Publikováno v:
Drug Metabolism and Disposition. 47:690-698
Naloxone (17-allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one HCl), a μ-opioid receptor antagonist, is administered intranasally to reverse an opioid overdose but its short half-life may necessitate subsequent doses. The addition of naltrexone [17-(c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5785e5e5280d7842c60dd7d27eb66b1b
https://doi.org/10.1124/dmd.118.085977
https://doi.org/10.1124/dmd.118.085977
Publikováno v:
Journal of Clinical Pharmacology
Based on its high affinity for μ opiate receptors and reported half‐life after oral administration, the pharmacokinetic properties of intranasal naltrexone were examined to evaluate its potential to treat opioid overdose. This study was prompted b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a281606f27b4a3349d768415cf37a6b
https://doi.org/10.1002/jcph.1384
https://doi.org/10.1002/jcph.1384
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 371(2)
The dramatic rise in overdose deaths linked to synthetic opioids (e.g., fentanyl, carfentanil) may require more potent, longer-duration opiate antagonists than naloxone. Both the high affinity of nalmefene at μ opiate receptors and its long half-lif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d846935505dbce1a3d0a9daa5938687
https://pubmed.ncbi.nlm.nih.gov/30940694
https://pubmed.ncbi.nlm.nih.gov/30940694
Autor:
Roger Crystal, Jennifer Harris, Melissa Beck, Shwe Gyaw, Philip Krieter, Fintan Keegan, Julie Aker, Nora Chiang, Phil Skolnick
Publikováno v:
The Journal of Clinical Pharmacology. 56:1243-1253
Parenteral naloxone has been approved to treat opiate overdose for over 4 decades. Intranasal naloxone, administered "off label" using improvised devices, has been widely used by both first responders and the lay public to treat overdose. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8318cd0bfa94ee942c425411c71d4676
https://doi.org/10.1002/jcph.759
https://doi.org/10.1002/jcph.759
Publikováno v:
J Clin Pharmacol
For over a decade, first responders and the general public have been able to treat suspected opioid overdoses using an improvised nasal naloxone device (INND) constructed from a prefilled syringe containing 2 mg of naloxone (1 mg/mL) attached to a mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc86c19ea7e1dd5d54cec7495b0b139
https://pubmed.ncbi.nlm.nih.gov/30861160
https://pubmed.ncbi.nlm.nih.gov/30861160
Autor:
Philip, Krieter, Nora, Chiang, Shwe, Gyaw, Phil, Skolnick, Roger, Crystal, Fintan, Keegan, Julie, Aker, Melissa, Beck, Jennifer, Harris
Publikováno v:
Journal of clinical pharmacology. 56(10)
Parenteral naloxone has been approved to treat opiate overdose for over 4 decades. Intranasal naloxone, administered "off label" using improvised devices, has been widely used by both first responders and the lay public to treat overdose. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a978428543a55cdddb5c1af33f5f445
https://pubmed.ncbi.nlm.nih.gov/27145977
https://pubmed.ncbi.nlm.nih.gov/27145977
Publikováno v:
Textbook of Addiction Treatment: International Perspectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e0ade1b2a8e14ad1240c4069077bc98
https://doi.org/10.1007/978-88-470-5322-9_82
https://doi.org/10.1007/978-88-470-5322-9_82
Publikováno v:
Textbook of Addiction Treatment: International Perspectives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75bf48199425a7f27cf2b9f8632abcad
https://doi.org/10.1007/978-88-470-5322-9_81
https://doi.org/10.1007/978-88-470-5322-9_81
Publikováno v:
Blood. 112:1987-1987
Sym001 is the first compound in a new class of biopharmaceuticals in clinical development for the treatment of Immune Thrombocytopenic Purpura (ITP), and the prevention of hemolytic disease of the newborn by anti-D prophylaxis (ADP). Sym001 is a reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d97dc2f865195ac18f0de0cfcf5549d0
https://doi.org/10.1182/blood.v112.11.1987.1987
https://doi.org/10.1182/blood.v112.11.1987.1987
Autor:
Orit Cohen-Barak, Rom E. Eliaz, Nora Chiang, David J. McCann, Yossi Gilgun-Sherki, Pippa S. Loupe, Hussein Hallak, Eli Eyal, Kathleen Blatt, Shwe Gyaw
Publikováno v:
Drug and Alcohol Dependence. :13-20
Background TV‐1380 (AlbuChE) is a novel recombinant fusion protein of mutated butyrylcholinesterase (BChE) that has increased catalytic efficiency for cocaine metabolism compared to wild-type BChE. Methods Intra-muscular injections of TV-1380 (150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5ac2f754959d1b522423236099b728