Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Shuye, Pu"'
Autor:
Syed Nabeel-Shah, Shuye Pu, Giovanni L. Burke, Nujhat Ahmed, Ulrich Braunschweig, Shaghayegh Farhangmehr, Hyunmin Lee, Mingkun Wu, Zuyao Ni, Hua Tang, Guoqing Zhong, Edyta Marcon, Zhaolei Zhang, Benjamin J. Blencowe, Jack F. Greenblatt
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-34 (2024)
Abstract Background N6-methyladenosine (m6A), the most abundant internal modification on eukaryotic mRNA, and N6, 2′-O-dimethyladenosine (m6Am), are epitranscriptomic marks that function in multiple aspects of posttranscriptional regulation. Fat ma
Externí odkaz:
https://doaj.org/article/4328bd3f4ab2479fba71d2541dde57fd
Autor:
Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-22 (2023)
Abstract Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into
Externí odkaz:
https://doaj.org/article/e4f36e6d55c941bfb45b7fa551f9ce48
Autor:
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kevin R. Brown, Henry Ward, Maximilian Billmann, Kamaldeep Aulakh, Audrey Astori, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Shuye Pu, Andrea Habsid, Amy Hin Yan Tong, Natasha Christie-Holmes, Patrick Budylowski, Ayoob Ghalami, Samira Mubareka, Finlay Maguire, Arinjay Banerjee, Karen L. Mossman, Jack Greenblatt, Scott D. Gray-Owen, Brian Raught, Benjamin J. Blencowe, Mikko Taipale, Chad Myers, Jason Moffat
Publikováno v:
Heliyon, Vol 9, Iss 1, Pp e12744- (2023)
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host factor dependencies ma
Externí odkaz:
https://doaj.org/article/1fc0974096af4f23af93d99b3d0085a0
Autor:
Syed Nabeel-Shah, Hyunmin Lee, Nujhat Ahmed, Giovanni L. Burke, Shaghayegh Farhangmehr, Kanwal Ashraf, Shuye Pu, Ulrich Braunschweig, Guoqing Zhong, Hong Wei, Hua Tang, Jianyi Yang, Edyta Marcon, Benjamin J. Blencowe, Zhaolei Zhang, Jack F. Greenblatt
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103562- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is essential for viral replication, making it a promising target for antiviral drug and vaccine development. SARS-CoV-2 infected patients exhibit an uncoor
Externí odkaz:
https://doaj.org/article/71c0d267688a465ca9051e412cc3eba6
Autor:
Zhong Yao, Betty Geng, Edyta Marcon, Shuye Pu, Hua Tang, John Merluza, Alexander Bello, Jamie Snider, Ping Lu, Heidi Wood, Igor Stagljar
Publikováno v:
Journal of Molecular Biology. 435:168128
SARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible to reductive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c2c12f699454910d82108a93bb7036
https://doi.org/10.1016/j.jmb.2023.168128
https://doi.org/10.1016/j.jmb.2023.168128
Autor:
Syed Nabeel-Shah, Jack Greenblatt, Jean-Philippe Lambert, Suzanne Wahab, Zhaolei Zhang, Hyunmin Lee, Jacob Fine, Marcelo Ponce, Ronald E. Pearlman, Edyta Marcon, Jeffrey Fillingham, Nujhat Ahmed, Kanwal Ashraf, Alejandro Saettone, Joanna Derynck, Shuye Pu, Jyoti Garg
Publikováno v:
Nucleic Acids Research
Retinoblastoma-binding proteins 4 and 7 (RBBP4 and RBBP7) are two highly homologous human histone chaperones. They function in epigenetic regulation as subunits of multiple chromatin-related complexes and have been implicated in numerous cancers. Due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf95a56e759d3cfb7cf481761649053
http://europepmc.org/articles/PMC8216455
http://europepmc.org/articles/PMC8216455
Autor:
Edyta Marcon, Zuyao Ni, Shuye Pu, Andrei L. Turinsky, Sandra Smiley Trimble, Jonathan B. Olsen, Rosalind Silverman-Gavrila, Lorelei Silverman-Gavrila, Sadhna Phanse, Hongbo Guo, Guoqing Zhong, Xinghua Guo, Peter Young, Swneke Bailey, Denitza Roudeva, Dorothy Zhao, Johannes Hewel, Joyce Li, Susanne Gräslund, Marcin Paduch, Anthony A. Kossiakoff, Mathieu Lupien, Andrew Emili, Shoshana J. Wodak, Jack Greenblatt
Publikováno v:
Cell Reports, Vol 8, Iss 1, Pp 297-310 (2014)
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, th
Externí odkaz:
https://doaj.org/article/1fec600c0aea446f95652573d57c6bfd
Autor:
Jingwen Song, Syed Nabeel-Shah, Shuye Pu, Hyunmin Lee, Ulrich Braunschweig, Zuyao Ni, Nujhat Ahmed, Edyta Marcon, Guoqing Zhong, Debashish Ray, Kevin C.H. Ha, Xinghua Guo, Zhaolei Zhang, Timothy R. Hughes, Benjamin J. Blencowe, Jack F. Greenblatt
Publikováno v:
Molecular cell. 82(17)
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the diversity of mRNA transcripts. 3' UTR shortening through APA correlates with enhanced cellular proliferation and is a widespread phenomenon in tumor cells. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdfbdef69d011fe8b895b0c8a72b854
https://pubmed.ncbi.nlm.nih.gov/35914531
https://pubmed.ncbi.nlm.nih.gov/35914531
Autor:
Shaghayegh Farhangmehr, Syed Nabeel-Shah, Shuye Pu, Benjamin J. Blencowe, Nitoiu A, Ulrich Braunschweig, Jack Greenblatt
Cys2His2 (C2H2) type zinc finger (ZnF) proteins constitute a large class of proteins that are generally considered to be DNA-binding transcription factors. Using affinity purification followed by mass spectrometry, as well as reciprocal co-immunoprec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e604801795bd1953381e114037af7076
https://doi.org/10.1101/2021.09.29.462476
https://doi.org/10.1101/2021.09.29.462476
Autor:
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Kamaldeep Aulakh, Kevin R. Brown, Shahan Haider, Edyta Marcon, Ulrich Braunschweig, Amy Hin Yan Tong, Shuye Pu, Andrea Habsid, Natasha Christie-Holmes, Patrick Budylowski, Audrey Astori, Ayoob Ghalami, Samira Mubareka, Arinjay Banerjee, Karen L. Mossman, Jack Greenblatt, Scott D. Gray-Owen, Brian Raught, Benjamin J. Blencowe, Mikko Taipale, Jason Moffat
SUMMARYSARS-CoV-2, depends on host cell components for replication, therefore the identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection. Such host factors may be necessary for infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c404dd92076179177cbf643a9df0d18
https://doi.org/10.1101/2021.06.28.450244
https://doi.org/10.1101/2021.06.28.450244